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PBE - ETF AI Analysis

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PBE

Invesco Dynamic Biotechnology & Genome ETF (PBE)

Rating:71Outperform
Price Target:
PBE, the Invesco Dynamic Biotechnology & Genome ETF, has a solid overall rating that reflects its focus on financially strong, growing biotech leaders. Top holdings like Royalty Pharma, Vertex, Regeneron, Gilead, and United Therapeutics support the fund’s quality through robust revenue growth, positive earnings calls, and generally favorable long-term outlooks, even if some face high valuations or debt. The rating is held back somewhat by weaker names like Legend Biotech, which struggles with profitability and cash flow, and by the fund’s concentration in the biotechnology sector, which can make it more volatile and sensitive to industry-specific risks.
Positive Factors
Leading Biotech Holdings
Several top positions, including United Therapeutics, Protagonist Therapeutics, and TG Therapeutics, have shown strong gains, helping support the fund’s overall results.
Focused Exposure to Health Care Innovation
The ETF is heavily invested in U.S. biotechnology and genome companies, giving investors targeted exposure to a key growth area in health care.
Recent Short-Term Momentum
The fund’s performance over the past month has been strong, indicating improving short-term momentum despite weaker results over longer periods.
Negative Factors
High Sector Concentration
Almost all assets are in the health care sector, so the fund is highly sensitive to swings in biotech and pharmaceutical markets.
Limited Geographic Diversification
With nearly all holdings in U.S. companies, investors get little protection from downturns in the U.S. market.
Relatively High Expense Ratio
The fund’s fee is on the higher side for an ETF, which can eat into returns over time, especially if performance remains uneven.

PBE vs. SPDR S&P 500 ETF (SPY)

PBE Summary

The Invesco Dynamic Biotechnology & Genome ETF (PBE) tracks the Dynamic Biotech & Genome Intellidex Index, focusing on U.S. biotech and genome companies working on new drugs and genetic treatments. It holds well-known names like Amgen and Gilead Sciences, along with smaller, fast-moving innovators. Someone might invest in PBE to seek long-term growth from medical breakthroughs and to get a basket of biotech stocks in a single investment instead of picking individual companies. However, biotech shares can be very volatile, so the ETF’s price can swing sharply and may go up or down more than the overall market.
How much will it cost me?The expense ratio for the Invesco Dynamic Biotechnology & Genome ETF (PBE) is 0.58%, which means you’ll pay $5.80 per year for every $1,000 invested. This is higher than average because the fund is actively managed, focusing on specialized biotechnology and genomic research companies that require more in-depth analysis and management.
What would affect this ETF?The Invesco Dynamic Biotechnology & Genome ETF (PBE) could benefit from advancements in biotechnology and genomic research, as well as increased demand for innovative healthcare solutions. However, it may face challenges from regulatory changes, high research and development costs, or economic downturns that could impact funding for biotech companies. The ETF’s focus on U.S.-based firms and top holdings like Vertex Pharmaceuticals and Gilead Sciences highlights its reliance on the performance of leading biotech innovators.

PBE Top 10 Holdings

PBE is a pure-play U.S. biotech fund, and its story is all about a concentrated bet on drug developers and genomic innovators. On the upside, Illumina, TG Therapeutics, and Catalyst Pharma have been rising, giving the ETF a lift as investors warm to growth in sequencing, oncology, and rare-disease treatments. United Therapeutics and Gilead have been steady contributors, quietly supporting returns. Offsetting that strength, Regeneron and Alnylam have been losing steam lately, acting as a drag and reminding investors how volatile this corner of health care can be.
Name
Company Name
Weight %
Market Value
Market Cap
Yearly Gain
Overall Rating
Royalty Pharma5.11%$13.05M$31.69B65.39%
79
Outperform
Biogen5.08%$12.98M$29.00B46.73%
74
Outperform
Amgen5.04%$12.87M$186.52B20.41%
77
Outperform
Alnylam Pharma4.96%$12.66M$40.54B0.74%
60
Neutral
Vertex Pharmaceuticals4.92%$12.56M$112.12B-0.81%
78
Outperform
Regeneron4.89%$12.47M$65.92B28.84%
78
Outperform
Gilead Sciences4.83%$12.33M$160.39B14.85%
78
Outperform
United Therapeutics4.77%$12.17M$23.25B68.76%
79
Outperform
Legend Biotech3.33%$8.50M$6.35B-6.80%
46
Neutral
Illumina3.22%$8.22M$25.43B96.37%
71
Outperform

PBE Technical Analysis

Technical Analysis Sentiment
Positive
Last Price
Price Trends
50DMA
80.89
Positive
100DMA
80.77
Positive
200DMA
77.92
Positive
Market Momentum
MACD
0.65
Negative
RSI
56.74
Neutral
STOCH
75.14
Neutral
Evaluating momentum and price trends is crucial in ETF analysis to make informed investment decisions. For PBE, the sentiment is Positive. The current price of undefined is equal to the 20-day moving average (MA) of 82.39, equal to the 50-day MA of 80.89, and equal to the 200-day MA of 77.92, indicating a bullish trend. The MACD of 0.65 indicates Negative momentum. The RSI at 56.74 is Neutral, neither overbought nor oversold. The STOCH value of 75.14 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PBE.

PBE Peer Comparison

Comparison Results
Name
Price
Price Target
AUM
Expense Ratio
Overall Rating
$259.85M0.58%
71
Outperform
$935.45M0.38%
69
Neutral
$893.34M0.38%
70
Outperform
$857.13M0.61%
71
Outperform
$630.56M0.40%
71
Outperform
$150.33M0.50%
52
Neutral
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PBE
Invesco Dynamic Biotechnology & Genome ETF
83.48
18.80
29.07%
IHF
iShares U.S. Healthcare Providers ETF
IHE
iShares U.S. Pharmaceuticals ETF
FXH
First Trust Health Care AlphaDEX Fund
RSPH
Invesco S&P 500 Equal Weight Health Care ETF
SBIO
ALPS Medical Breakthroughs ETF
Glossary
BuyAn ETF rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF is likely to deliver higher returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldAn ETF rated as a "Hold" s expected to perform in line with the overall market or a specific benchmark. This rating indicates that the ETF is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellAn ETF rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF may deliver lower returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
DisclaimerThis AI Analyst ETF Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in ETFs carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: ―
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