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GRAIL Inc (GRAL)
NASDAQ:GRAL
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GRAIL Inc (GRAL) AI Stock Analysis

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GRAL

GRAIL Inc

(NASDAQ:GRAL)

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Neutral 59 (OpenAI - 4o)
Rating:59Neutral
Price Target:
$34.00
▼(-60.65% Downside)
GRAIL Inc.'s overall stock score reflects strong revenue growth and positive developments from the earnings call, tempered by significant profitability challenges and poor valuation metrics. The technical analysis indicates bearish momentum, further impacting the score.
Positive Factors
Revenue Growth
Sustained revenue growth indicates increasing market adoption of Galleri, enhancing GRAIL's market position and long-term business prospects.
Partnership Expansion
Strategic partnerships expand market access and integration into healthcare systems, driving adoption and supporting long-term revenue growth.
Clinical Trial Success
Positive clinical trial results enhance product credibility and could lead to wider acceptance and regulatory support, boosting long-term growth.
Negative Factors
Profitability Challenges
Persistent losses and negative margins indicate ongoing operational inefficiencies, which could hinder financial sustainability and growth potential.
Cash Flow Challenges
Negative free cash flow highlights reliance on external financing, which could limit flexibility and increase risk if funding conditions tighten.
Operational Challenges
Operational inefficiencies could impact customer satisfaction and increase costs, potentially affecting long-term profitability and market competitiveness.

GRAIL Inc (GRAL) vs. SPDR S&P 500 ETF (SPY)

GRAIL Inc Business Overview & Revenue Model

Company DescriptionGRAIL, Inc., a biotechnology company, focuses on developing technologies for early cancer detection. The company develops Galleri, a screening test for asymptomatic individuals over 50 years of age; and DAC, a diagnostic aid for cancer tests to accelerate diagnostic resolution for patients for whom there is a clinical suspicion of cancer. It is also developing minimal residual disease and other post-diagnostic tests. The company was incorporated in 2015 and is based in Menlo Park, California. GRAIL, Inc. operates as a former subsidiary of Illumina, Inc.
How the Company Makes MoneyGRAIL generates revenue primarily through the sale of its multi-cancer early detection tests to healthcare providers, hospitals, and laboratories. The company operates a direct-to-consumer model as well, allowing individuals to access its testing services. Key revenue streams include the fees charged for each test performed, as well as potential partnerships with healthcare organizations and insurers that may facilitate broader access to its products. GRAIL also benefits from collaborations with pharmaceutical companies and research institutions, which may involve funding for clinical studies or development efforts aimed at integrating its testing solutions into broader cancer care protocols.

GRAIL Inc Earnings Call Summary

Earnings Call Date:Aug 12, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Nov 18, 2025
Earnings Call Sentiment Positive
The earnings call presented a mix of positive developments in commercial growth, clinical trial results, and financial management, alongside operational challenges and high net loss. The positive aspects, including strong revenue growth and clinical trial outcomes, slightly outweigh the lowlights, indicating a cautiously optimistic outlook.
Q2-2025 Updates
Positive Updates
Strong Commercial Growth
Galleri test orders grew significantly with more than 45,000 commercial tests sold in Q2, contributing to over 370,000 tests prescribed since its launch in 2021.
Positive Clinical Trial Results
PATHFINDER 2 study showed substantially greater additional cancer detection and a higher positive predictive value compared to the first PATHFINDER study.
Revenue Growth
GRAIL reported Q2 revenue of $35.5 million, an 11% increase from the same period in 2024, with U.S. Galleri revenue up 21%.
Partnership Expansion
GRAIL established new partnerships, including with Rush University System for Health and Everlywell, to expand the availability of Galleri.
Improved Financials
Net loss improved by 93% compared to Q2 2024, with cash burn guidance updated to no more than $310 million for 2025, down from previously projected numbers.
Negative Updates
Operational Challenges
The company faced increased turnaround times and higher reprocessing costs for a small proportion of samples due to the new Galleri version's complexity.
High Net Loss
Despite improvements, GRAIL reported a net loss of $114 million for Q2, including impairments and stock-based compensation costs.
Cost of Screening Revenue
Decreased as a percent of revenue due to a 6% decrease in ASP and additional sample reprocessing costs.
Company Guidance
During GRAIL's second quarter 2025 earnings call, the company highlighted several key performance metrics and financial results. GRAIL reported second-quarter revenue of $35.5 million, an 11% increase from the previous year, with screening revenue accounting for $34.4 million. The company sold over 45,000 Galleri tests in the quarter, contributing to a total of more than 370,000 tests prescribed by over 15,000 healthcare providers since the product's commercial launch in 2021. Galleri's positive predictive value (PPV) was notably higher in the PATHFINDER 2 study compared to the first PATHFINDER study, with a specificity of 99.5% and a cancer signal origin accuracy of 88%. Additionally, GRAIL's cash position was $606.1 million, and it revised its full-year cash burn guidance to no more than $310 million, a decrease of more than 40% compared to 2024. The company also plans to submit detailed PATHFINDER 2 study results for presentation at the ESMO Congress 2025 in October.

GRAIL Inc Financial Statement Overview

Summary
GRAIL Inc. shows strong revenue growth but faces significant profitability challenges with negative profit margins. The company maintains a strong equity position and low leverage, indicating financial stability, but negative free cash flow and reliance on external financing are concerns.
Income Statement
58
Neutral
GRAIL Inc. has shown substantial revenue growth with a 34.89% increase from 2023 to 2024. However, the company continues to operate at a loss with a negative gross profit margin of -62.12% and a net profit margin of -161.42% in 2024. The EBIT and EBITDA margins are also negative, indicating ongoing operational challenges.
Balance Sheet
72
Positive
GRAIL Inc. maintains a strong equity position with an equity ratio of 83.92%. The debt-to-equity ratio is low at 0.03, signifying limited leverage. However, the return on equity is negative due to ongoing losses. The company's high stockholders' equity relative to total assets suggests financial stability but profitability remains a concern.
Cash Flow
65
Positive
The operating cash flow to net income ratio is 0.28, indicating cash flow challenges. Free cash flow has improved slightly, but remains negative at -$582.36 million. The company raised $1.24 billion in financing activities, aiding liquidity but highlighting reliance on external funding.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2020Dec 2019
Income Statement
Total Revenue134.28M125.59M93.11M55.55M0.000.00
Gross Profit-7.29M-78.02M-95.61M-116.45M0.00-10.31M
EBITDA-469.82M-610.17M-1.35B-587.70M-308.73M-243.14M
Net Income-442.95M-2.03B-1.47B-5.40B-312.16M-244.85M
Balance Sheet
Total Assets2.70B2.98B3.91B5.60B706.30M635.52M
Cash, Cash Equivalents and Short-Term Investments602.75M763.47M97.29M241.60M583.48M544.34M
Total Debt62.16M68.14M84.41M96.01M62.99M42.04M
Total Liabilities387.91M479.90M267.63M955.94M144.46M84.99M
Stockholders Equity2.31B2.50B3.65B4.65B561.84M550.53M
Cash Flow
Free Cash Flow-371.75M-582.36M-608.69M-584.17M-243.91M-249.13M
Operating Cash Flow-370.05M-577.16M-595.80M-561.31M-232.00M-245.79M
Investing Cash Flow-462.10M-551.01M-12.89M-22.86M-12.79M133.04M
Financing Cash Flow0.001.24B463.77M604.82M275.11M160.33M

GRAIL Inc Technical Analysis

Technical Analysis Sentiment
Positive
Last Price86.41
Price Trends
50DMA
45.29
Positive
100DMA
43.01
Positive
200DMA
37.04
Positive
Market Momentum
MACD
9.47
Negative
RSI
80.28
Negative
STOCH
81.59
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GRAL, the sentiment is Positive. The current price of 86.41 is above the 20-day moving average (MA) of 61.21, above the 50-day MA of 45.29, and above the 200-day MA of 37.04, indicating a bullish trend. The MACD of 9.47 indicates Negative momentum. The RSI at 80.28 is Negative, neither overbought nor oversold. The STOCH value of 81.59 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for GRAL.

GRAIL Inc Risk Analysis

GRAIL Inc disclosed 74 risk factors in its most recent earnings report. GRAIL Inc reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

GRAIL Inc Peers Comparison

Overall Rating
UnderperformOutperform
Sector (55)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
70
Neutral
$24.78B-24.32%44.38%22.87%
61
Neutral
$14.29B11.7868.11%-3.32%
59
Neutral
$2.72B-17.68%22.37%86.08%
57
Neutral
$8.41B-4584.47%28.74%18.25%
55
Neutral
$6.65B3.83-15.92%6.20%10.91%7.18%
52
Neutral
$751.80M-70.03%3.83%-137.31%
51
Neutral
$1.29B-11.76%9.70%-30.94%
* General Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GRAL
GRAIL Inc
86.41
71.65
485.43%
ILMN
Illumina
95.91
-50.16
-34.34%
MYGN
Myriad Genetics
8.08
-15.31
-65.46%
NEO
NeoGenomics
10.28
-3.28
-24.19%
NTRA
Natera
180.54
58.14
47.50%
GH
Guardant Health
67.47
46.09
215.58%

GRAIL Inc Corporate Events

Executive/Board ChangesShareholder Meetings
GRAIL Inc Holds Annual Stockholders Meeting
Neutral
May 30, 2025

On May 29, 2025, GRAIL, Inc. held its Annual Meeting of Stockholders with a quorum of 29,682,974 shares represented. During the meeting, stockholders elected William Chase as a Class I Director to serve until 2028 and ratified Ernst & Young LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2025.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Sep 05, 2025