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IBBQ

Invesco Nasdaq Biotechnology ETF (IBBQ)

Rating:65Neutral
Price Target:$38.00â–²(4.22% Upside)

IBBQ, the Invesco Nasdaq Biotechnology ETF, has a solid overall rating driven mainly by strong, established biotech leaders like Gilead, Amgen, Vertex, Regeneron, and Royalty Pharma, which show robust financial performance, healthy pipelines, and generally favorable long-term outlooks. However, weaker names such as Moderna and Revolution Medicines, which face revenue declines, ongoing losses, and bearish technical trends, weigh on the fund’s quality. The main risk factor is its concentrated exposure to the biotechnology sector, meaning the ETF’s performance is heavily tied to the fortunes and volatility of biotech companies.

Positive Factors
Strong Year-to-Date PerformanceThe ETF has delivered strong gains so far this year, showing solid momentum in the biotechnology sector.
Leading Biotech HoldingsSeveral large positions like Amgen, Gilead Sciences, and Vertex Pharmaceuticals have shown strong or steady performance, helping support the fund’s returns.
Low Expense RatioThe fund’s relatively low annual fee means more of the investment gains can stay in investors’ pockets over time.
Negative Factors
Heavy Sector ConcentrationAlmost all of the ETF’s assets are in health care and biotechnology, which increases risk if this single sector faces a downturn.
Limited Geographic DiversificationThe fund is almost entirely invested in U.S. companies, offering little protection if the U.S. market or regulatory environment for biotech weakens.
Mixed Performance Among Top HoldingsWhile many top holdings are performing well, some positions like Alnylam Pharma have been weak, which can drag on overall returns.

IBBQ vs. SPDR S&P 500 ETF (SPY)

-10%0%10%20%30%40%SPY+10.92%IBBQ+34.05%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
AUM
131.39M
Region
North America
Expense Ratio
0.19%
Beta
0.76
Issuer
Invesco
Inception Date
Jun 11, 2021
Dividend Yield
1.07%
Asset Class
Equity
Index Tracked
NASDAQ / Biotechnology

IBBQ Summary

IBBQ is the Invesco Nasdaq Biotechnology ETF, which follows the Nasdaq Biotechnology Index. It focuses on U.S. health care companies in biotech and pharmaceuticals, giving you a way to invest in firms working on new drugs, vaccines, and medical treatments. Well-known holdings include Gilead Sciences and Amgen. Someone might invest in IBBQ to tap into the long-term growth potential of innovative biotech companies while getting diversification across many stocks instead of picking just one. A key risk is that biotech shares can be very volatile, so the ETF’s value can rise and fall sharply with news, drug approvals, or market swings.

How much will it cost me?

IBBQ has an expense ratio of 0.19%, which means you’ll pay about $1.90 per year for every $1,000 invested. This cost is slightly higher than the cheapest broad-market index ETFs but still reasonable for a specialized, passively managed biotech sector fund.

What would affect this ETF?

IBBQ could benefit if demand for new medicines and biotech innovations grows, helping major U.S. holdings like Gilead, Amgen, Vertex, and Moderna, especially when health care spending is strong and regulation is supportive. On the downside, stricter drug pricing rules, setbacks in clinical trials, or a weaker U.S. economy could hurt these companies, and changes in interest rates or investor sentiment toward riskier sectors may also weigh on this biotech-focused ETF.

IBBQ Top 10 Holdings

IBBQ is essentially a bet on big U.S. biotech, with heavyweights like Amgen, Gilead, Vertex, and Regeneron steering the ship. These names have been steadily rising, giving the fund a solid core of profitable, established drug makers. Moderna adds more drama, with sharp recent gains driven by momentum rather than stable fundamentals, while Illumina’s rebound in genomics has helped brighten the picture. On the flip side, Alnylam and Revolution Medicines are more mixed and occasionally drag on returns, reminding investors this is a high‑innovation, high‑volatility corner of health care.

IBBQ top ten holdings
NameCompany NameWeight %Market ValueMarket CapYearly GainOverall Rating
GILDGILDGilead Sciences8.97%$11.47M$211.94B44.62%78Outperform
AMGNAMGNAmgen8.42%$10.78M$251.65B43.74%77Outperform
VRTXVRTXVertex Pharmaceuticals7.90%$10.11M$138.91B30.08%78Outperform
MRNAMRNAModerna6.53%$8.35M$101.49B913.05%59Neutral
REGNREGNRegeneron5.88%$7.52M$94.75B39.91%78Outperform
RVMDRVMDRevolution Medicines2.65%$3.39M$41.76B207.76%52Neutral
BIIBBIIBBiogen2.36%$3.02M$37.44B62.07%74Outperform
ILMNILMNIllumina2.07%$2.65M$32.49B76.56%71Outperform
RPRXRPRXRoyalty Pharma1.93%$2.47M$39.84B80.20%79Outperform
ROIVROIVRoivant Sciences1.81%$2.31M$29.84B94.57%58Neutral

IBBQ Technical Analysis

Technical Analysis SentimentPositive
Last Price36.46

Price Trends

50DMA34.97Positive
100DMA34.10Positive
200DMA31.58Positive

Market Momentum

MACD0.47Negative
RSI56.97Neutral
STOCH72.60Neutral

Evaluating momentum and price trends is crucial in ETF analysis to make informed investment decisions. For IBBQ, the sentiment is Positive. The current price of 36.46 is above the 20-day moving average (MA) of 35.35, above the 50-day MA of 34.97, and above the 200-day MA of 31.58, indicating a bullish trend. The MACD of 0.47 indicates Negative momentum. The RSI at 56.97 is Neutral, neither overbought nor oversold. The STOCH value of 72.60 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for IBBQ.

IBBQ Peer Comparison

Comparison Results

IBBQ against its peer funds
NamePricePrice TargetAUMExpense RatioOverall Rating
IBBQIBBQ$36.46$38.00(4.22% Upside)$131.39M0.19%65Neutral
PJPPJP$130.54$160.98(23.32% Upside)$600.27M0.58%70Neutral
XPHXPH$67.93$104.39(53.68% Upside)$477.16M0.35%58Neutral
PBEPBE$99.62$128.62(29.11% Upside)$443.95M0.59%70Outperform
PINKPINK$40.63$48.36(19.03% Upside)$348.97M0.51%67Neutral
LFSCLFSC$46.69$68.16(45.96% Upside)$125.23M0.54%50Neutral

Performance Comparison

0%20%40%IBBQPJPXPHPBEPINKLFSCDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
IBBQ and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
IBBQInvesco Nasdaq Biotechnology ETF36.469.2233.85%
PJPInvesco Dynamic Pharmaceuticals ETF130.5429.3028.94%
XPHSPDR S&P Pharmaceuticals ETF67.9317.2634.07%
PBEInvesco Dynamic Biotechnology & Genome ETF99.6222.4329.05%
PINKSimplify Health Care ETF40.636.1217.74%
LFSCF/M Emerald Life Sciences Innovation ETF46.6911.8534.02%
Glossary
BuyAn ETF rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF is likely to deliver higher returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldAn ETF rated as a "Hold" s expected to perform in line with the overall market or a specific benchmark. This rating indicates that the ETF is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellAn ETF rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF may deliver lower returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer

This AI Analyst ETF Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in ETFs carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.