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Serina Therapeutics, Inc. (SER)
:SER
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Serina Therapeutics (SER) AI Stock Analysis

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SER

Serina Therapeutics

(NYSE MKT:SER)

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Neutral 44 (OpenAI - 4o)
Rating:44Neutral
Price Target:
$5.00
▲(3.95% Upside)
The overall stock score for Serina Therapeutics is primarily impacted by its poor financial performance, which is the most significant factor. The company's financial instability and operational inefficiencies are major concerns. Technical analysis provides mixed signals, offering some neutral indicators but overall suggesting a bearish trend. Valuation metrics are unfavorable due to negative profitability and lack of dividends, further weighing down the score.
Positive Factors
Innovative Drug Delivery Systems
The company's focus on innovative drug delivery systems provides a competitive advantage by enhancing the efficacy and safety of therapies, potentially leading to strong partnerships and revenue growth.
Strategic Partnerships
Strategic partnerships with pharmaceutical companies provide a stable revenue stream and opportunities for growth through collaborative drug development, leveraging Serina's proprietary technologies.
Focus on Unmet Medical Needs
Targeting unmet medical needs positions Serina Therapeutics in high-demand markets, potentially driving long-term growth as it addresses critical gaps in treatment options.
Negative Factors
High Liabilities
High liabilities and negative equity indicate financial instability, which could hinder the company's ability to invest in R&D and sustain operations without restructuring.
Negative Cash Flow
Negative cash flow from operations suggests difficulties in sustaining business activities, potentially requiring external funding and impacting long-term viability.
Declining Revenue
Declining revenue and negative profit margins highlight operational inefficiencies and market challenges, threatening the company's ability to achieve profitability.

Serina Therapeutics (SER) vs. SPDR S&P 500 ETF (SPY)

Serina Therapeutics Business Overview & Revenue Model

Company DescriptionSerina Therapeutics, Inc., a biotechnology company, develops drugs to treat neurological diseases and pain. Its lead product candidate is SER 252, a POZ conjugate for the treatment of Parkinson's disease. The company also develops SER 227 for long-acting pain relief; SER 214 to treat Parkinson's disease; and SER 228 for the treatment of epilepsy. In addition, it develops POZ technology in lipid nanoparticle delivered ribonucleic acid vaccines for infectious diseases. Serina Therapeutics, Inc. was founded in 2006 and is based in Huntsville, Alabama.
How the Company Makes MoneySerina Therapeutics generates revenue primarily through strategic partnerships and collaborations with pharmaceutical companies that seek to utilize its proprietary drug delivery technologies. The company may also earn income from licensing agreements for its developed products, as well as potential milestone payments and royalties from partnered drug development programs. Additionally, government grants and funding for research projects may contribute to the company's financial resources, allowing it to advance its product pipeline and expand its therapeutic offerings.

Serina Therapeutics Financial Statement Overview

Summary
Serina Therapeutics is facing severe financial challenges across all key financial statements. The income statement reflects substantial losses and declining revenue, the balance sheet is under strain due to high liabilities and negative equity, and cash flow issues point to operational inefficiencies. These factors collectively suggest a need for strategic restructuring or significant operational improvements to ensure future viability.
Income Statement
20
Very Negative
Serina Therapeutics has experienced significant volatility in revenue and profitability. The TTM data shows a drastic decline in revenue, leading to negative gross and net profit margins. This indicates severe inefficiencies and a struggle to generate sufficient income. Previous periods also reflect a trend of high losses, with EBIT and EBITDA margins persistently underperforming.
Balance Sheet
30
Negative
The balance sheet shows a concerning financial structure with a very low equity base and high liabilities, resulting in a negative equity in some periods. The debt-to-equity ratio is not ideal, and the return on equity is not calculable due to negative equity. This suggests high financial risk and instability.
Cash Flow
25
Negative
The cash flow statement highlights consistent negative free cash flow, indicating operational challenges. The operating cash flow is significantly negative, suggesting that the company struggles to generate cash from its core activities. Despite some positive financing activities, the overall cash flow position is weak.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue130.00K56.00K3.15M500.00K3.04M54.00K
Gross Profit2.00K-138.00K3.06M355.00K-110.00K-1.23M
EBITDA-12.47M-10.49M5.92M-7.05M-7.35M-8.74M
Net Income-12.59M-11.14M5.27M-2.68M-1.26M-10.87M
Balance Sheet
Total Assets8.94M6.72M11.96M858.04K1.84M3.92M
Cash, Cash Equivalents and Short-Term Investments6.04M3.67M7.62M532.23K1.31M527.00K
Total Debt185.00K268.00K4.37M1.81M398.17K6.30M
Total Liabilities7.29M6.22M6.61M38.64M36.95M9.32M
Stockholders Equity1.80M641.00K5.47M-17.21M-11.83M-5.12M
Cash Flow
Free Cash Flow-15.63M-17.16M-2.98M-2.09M-2.36M-7.84M
Operating Cash Flow-15.62M-17.14M-2.48M-2.08M-2.25M-7.82M
Investing Cash Flow-54.00K-22.00K-504.00K980.94K823.32K-20.00K
Financing Cash Flow15.60M13.21M10.07M1.31M1.08M5.96M

Serina Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price4.81
Price Trends
50DMA
5.19
Negative
100DMA
5.44
Negative
200DMA
5.25
Negative
Market Momentum
MACD
-0.04
Positive
RSI
41.08
Neutral
STOCH
11.38
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SER, the sentiment is Negative. The current price of 4.81 is below the 20-day moving average (MA) of 5.16, below the 50-day MA of 5.19, and below the 200-day MA of 5.25, indicating a bearish trend. The MACD of -0.04 indicates Positive momentum. The RSI at 41.08 is Neutral, neither overbought nor oversold. The STOCH value of 11.38 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for SER.

Serina Therapeutics Risk Analysis

Serina Therapeutics disclosed 78 risk factors in its most recent earnings report. Serina Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Serina Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
$53.74M-53.78%-5.42%
44
Neutral
$49.28M45.59%
40
Underperform
$52.85M-6367.24%4.45%45.19%
38
Underperform
$42.76M-72.75%72.65%
38
Underperform
$58.19M<0.01%86.28%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
SER
Serina Therapeutics
4.81
-2.70
-35.95%
OTLK
Outlook Therapeutics
1.31
-4.38
-76.98%
SKYE
Skye Bioscience
1.38
-3.33
-70.70%
CELU
Celularity
1.98
-0.12
-5.71%
BRNS
Barinthus Biotherapeutics
1.33
0.00
0.00%
JUNS
Jupiter Neurosciences, Inc.
1.59
-3.95
-71.30%

Serina Therapeutics Corporate Events

Business Operations and StrategyPrivate Placements and Financing
Serina Therapeutics Secures $20M for Parkinson’s Trial
Positive
Sep 9, 2025

On September 9, 2025, Serina Therapeutics announced securing up to $20 million in financing to advance the registrational trial of SER-252 for Parkinson’s disease. This funding, led by Board Director Greg Bailey, MD, will support the Phase 1b clinical study under the 505(b)(2) NDA pathway. The financing structure allows flexibility in capital deployment and includes potential additional proceeds through warrant issuance. The trial aims to evaluate the safety, tolerability, and pharmacokinetics of SER-252, a novel apomorphine therapy designed for continuous dopaminergic stimulation in advanced Parkinson’s patients. The study will be conducted in the U.S. and Australia, with key milestones anticipated in 2025 and 2026.

The most recent analyst rating on (SER) stock is a Hold with a $5.00 price target. To see the full list of analyst forecasts on Serina Therapeutics stock, see the SER Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 14, 2025