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PureTech Health (GB:PRTC)
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PureTech Health (PRTC) AI Stock Analysis

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GB:PRTC

PureTech Health

(LSE:PRTC)

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Neutral 59 (OpenAI - 4o)
Rating:59Neutral
Price Target:
135.00p
▲(0.15% Upside)
PureTech Health's stock score reflects a mixed financial performance with strong liquidity but profitability challenges. Technical indicators suggest potential resistance, while valuation appears favorable. The earnings call provided a cautiously optimistic outlook, tempered by management changes and funding uncertainties.

PureTech Health (PRTC) vs. iShares MSCI United Kingdom ETF (EWC)

PureTech Health Business Overview & Revenue Model

Company DescriptionPureTech Health (PRTC) is an innovative biopharmaceutical company focused on discovering, developing, and commercializing transformative therapies for patients with serious diseases. The company operates in various sectors, including neurology, immunology, and gastrointestinal disorders, leveraging its proprietary platform technologies to create a pipeline of novel therapeutics. Core products and services include drug development programs and strategic partnerships aimed at advancing its candidate therapies through clinical trials.
How the Company Makes MoneyPureTech Health generates revenue through multiple streams, including the licensing of its proprietary technologies and drug candidates to larger pharmaceutical companies, which pay upfront fees and potential milestone payments tied to the successful development and commercialization of these products. Additionally, the company may receive royalties on sales of products developed using its technologies. Strategic collaborations and partnerships with established firms in the industry also contribute to its revenue, providing funding for research and development efforts while allowing PureTech to share in the financial success of its partners. The company's ongoing clinical trials and advancements in its therapeutic pipeline further position it to attract investment and funding opportunities.

PureTech Health Earnings Call Summary

Earnings Call Date:Aug 28, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Apr 23, 2026
Earnings Call Sentiment Neutral
The earnings call presented a mixed picture. While PureTech demonstrated strong financial health and promising developments in its core programs, the recent management changes and ongoing efforts to secure external funding introduce some uncertainties. Overall, the company's strategic initiatives and financial position suggest a cautiously optimistic outlook.
Q2-2025 Updates
Positive Updates
Strong Financial Position
PureTech ended the half year with cash, cash equivalents, and short-term investments of just under $320 million, providing operational runway well into 2028.
Positive Progress with Core Founded Entities
Celea Therapeutics, Gallop Oncology, and Seaport Therapeutics are progressing well. Seaport raised over $325 million and has a $733 million post-money valuation. Celea's deupirfenidone shows promising results for IPF treatment.
Significant Upside from Cobenfy Royalties
PureTech is entitled to 2% royalties on Cobenfy sales above $2 billion annually, with a potential value of around $300 million over time.
Operational Efficiency Improvements
Operational expenses reduced significantly, with operating expenses of just under $50 million in the first half of 2025, down from $66.7 million in the same period last year.
Negative Updates
Management Changes
Recent management changes with an interim CEO and Chair, indicating potential instability or transition within the leadership team.
Uncertainty in Partnering and Funding
Ongoing efforts to secure external funding for Celea and Gallop, with no specific timelines or confirmed partners, creating uncertainty in future progress.
Company Guidance
During the PureTech Health 2025 Half Year Earnings Webcast, the company provided detailed guidance on its strategic priorities and financial metrics. PureTech emphasized its commitment to developing new treatments, highlighted by the clinical progress of its lead program, deupirfenidone (LYT-100), and the launch of new entities Celea Therapeutics and Gallop Oncology. The company outlined three strategic pillars: advancing patient-focused treatments, strengthening engagement with U.K. capital markets, and employing a disciplined capital allocation approach. PureTech plans to appoint two new nonexecutive directors to enhance its board's expertise in U.K. capital markets. Financially, PureTech reported cash and short-term investments totaling just under $320 million, with an operational runway extending well into 2028. The company is focused on leveraging external capital to fund its spinout entities while maintaining significant economic interests, exemplified by its 35.1% equity stake in Seaport Therapeutics, which recently had a post-money valuation of $733 million.

PureTech Health Financial Statement Overview

Summary
PureTech Health shows mixed financial performance with strong liquidity and low leverage, but faces challenges in profitability and cash flow sustainability. Volatile revenue and net income trends indicate operational risks.
Income Statement
45
Neutral
PureTech Health's income statement shows a volatile revenue base with a significant increase from 2023 to 2024. The gross profit margin is positive, but the company is operating at a loss with negative EBIT and EBITDA margins. Although the net profit margin turned positive in 2024, the overall profitability remains a concern due to inconsistent revenue and high operational losses.
Balance Sheet
55
Neutral
The balance sheet reflects a strong liquidity position with substantial cash reserves, resulting in a negative net debt. While the debt-to-equity ratio is low, indicating prudent leverage, the equity ratio has decreased, suggesting a decline in asset efficiency. The company's return on equity is volatile, driven by fluctuating net income, indicating instability in shareholder returns.
Cash Flow
50
Neutral
Cash flow analysis shows challenges with consistent negative free cash flow, though there was a significant increase in free cash flow from 2023 to 2024. The operating cash flow remains negative, indicating operational cash burn. The company’s cash flow management is buoyed by financing and investing activities, but sustainable operational improvements are needed.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue5.88M4.32M750.00K2.09M9.98M8.34M
Gross Profit19.91M4.32M-92.91M-136.81M-100.49M8.34M
EBITDA55.73M37.38M-17.68M-79.94M-46.95M-115.58M
Net Income50.68M53.51M-65.70M-50.35M-60.56M5.99M
Balance Sheet
Total Assets553.24M602.63M693.97M702.65M946.01M989.99M
Cash, Cash Equivalents and Short-Term Investments321.55M367.31M327.14M350.10M465.71M403.88M
Total Debt20.92M22.36M25.34M46.87M52.75M76.62M
Total Liabilities184.22M194.70M235.74M155.06M361.86M336.45M
Stockholders Equity375.98M414.71M464.07M542.22M593.51M669.75M
Cash Flow
Free Cash Flow-100.31M-134.38M-106.16M-180.97M-163.94M-137.25M
Operating Cash Flow-100.30M-134.37M-105.92M-178.79M-158.27M-131.83M
Investing Cash Flow34.05M240.89M68.99M-107.22M197.38M364.48M
Financing Cash Flow18.37M-16.96M78.14M-29.83M22.73M38.87M

PureTech Health Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price134.80
Price Trends
50DMA
127.26
Positive
100DMA
130.39
Positive
200DMA
132.76
Negative
Market Momentum
MACD
1.32
Positive
RSI
49.97
Neutral
STOCH
53.21
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:PRTC, the sentiment is Neutral. The current price of 134.8 is above the 20-day moving average (MA) of 133.70, above the 50-day MA of 127.26, and above the 200-day MA of 132.76, indicating a neutral trend. The MACD of 1.32 indicates Positive momentum. The RSI at 49.97 is Neutral, neither overbought nor oversold. The STOCH value of 53.21 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for GB:PRTC.

PureTech Health Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
£107.11M14.1164.40%6.75%-3.61%-6.38%
£319.02M9.2415.04%1231.50%
£789.76M-74.64%55.44%75.77%
$7.86B-0.30-43.30%2.27%22.53%-2.21%
£1.36B-26.01%22.03%20.01%
£102.22M-7.46-94.12%
£112.27M-7.30-209.34%198.49%-26.66%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:PRTC
PureTech Health
132.00
-28.00
-17.50%
GB:BVXP
Bioventix
2,050.00
-1,413.93
-40.82%
GB:SCLP
Scancell Holdings
9.85
-3.53
-26.38%
GB:OXB
Oxford BioMedica
657.00
249.00
61.03%
GB:4BB
4basebio UK Societas
790.00
-485.00
-38.04%
GB:ONT
Oxford Nanopore Technologies PLC
137.00
-1.00
-0.72%

PureTech Health Corporate Events

Business Operations and StrategyProduct-Related Announcements
PureTech Health’s Deupirfenidone Shows Promise in Treating Older IPF Patients
Positive
Oct 22, 2025

PureTech Health has announced new analyses from its Phase 2b ELEVATE IPF trial, demonstrating the consistent safety and efficacy of deupirfenidone in treating idiopathic pulmonary fibrosis (IPF) among older patients, a group historically undertreated due to tolerability issues. The findings, presented at the CHEST 2025 Annual Meeting, suggest that deupirfenidone could address a significant treatment gap for older IPF patients, potentially offering a new standard of care and improving outcomes for this vulnerable population.

The most recent analyst rating on (GB:PRTC) stock is a Hold with a £135.00 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
PureTech Health’s Deupirfenidone Shows Promise in IPF Treatment
Positive
Sep 29, 2025

PureTech Health has announced promising new data from its Phase 2b ELEVATE IPF trial for deupirfenidone (LYT-100), a potential new standard of care for idiopathic pulmonary fibrosis (IPF). The data, presented at the 2025 European Respiratory Society Congress, showed that patients switching from placebo or pirfenidone to deupirfenidone experienced stabilization of lung function with favorable tolerability, reinforcing the drug’s potential to address unmet needs in IPF treatment. The company is engaging with regulators to finalize the Phase 3 trial design, with updates expected in Q4 2025.

The most recent analyst rating on (GB:PRTC) stock is a Hold with a £130.00 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Other
PureTech Health Executives Increase Shareholdings, Indicating Confidence in Future Prospects
Positive
Sep 24, 2025

PureTech Health announced that key members of its management team, including the Interim CEO and several Non-Executive Directors, have purchased shares in the company. This transaction, conducted on the London Stock Exchange, signifies confidence in the company’s future prospects and may positively influence stakeholder sentiment.

The most recent analyst rating on (GB:PRTC) stock is a Hold with a £130.00 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Product-Related Announcements
Seaport Therapeutics Advances GlyphAgo for Generalized Anxiety Disorder
Positive
Sep 11, 2025

Seaport Therapeutics has initiated a Phase 1 clinical trial for GlyphAgo, an oral prodrug of agomelatine, aimed at treating generalized anxiety disorder (GAD). GlyphAgo is designed to improve drug absorption and reduce liver-related side effects, potentially redefining GAD treatment by achieving therapeutic benefits at lower doses without the need for frequent liver monitoring.

The most recent analyst rating on (GB:PRTC) stock is a Hold with a £130.00 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Regulatory Filings and Compliance
PureTech Health Discloses August 2025 Share Capital and Voting Rights
Neutral
Sep 1, 2025

PureTech Health announced its total voting rights and share capital as of August 31, 2025, with 257,927,489 ordinary shares issued and 16,243,451 held in treasury, resulting in 241,684,038 total voting rights. This disclosure is significant for shareholders who need to assess their interests under the FCA’s rules, impacting their investment decisions and the company’s transparency in the market.

The most recent analyst rating on (GB:PRTC) stock is a Hold with a £130.00 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

PureTech Health’s Earnings Call: Cautious Optimism Amidst Changes
Sep 1, 2025

The recent earnings call for PureTech Health painted a picture of cautious optimism. The company showcased its strong financial health and promising advancements in its core programs, yet the recent management changes and ongoing efforts to secure external funding introduced some uncertainties. Overall, the strategic initiatives and financial position of PureTech suggest a cautiously optimistic outlook.

Business Operations and StrategyExecutive/Board ChangesFinancial Disclosures
PureTech Health Advances Portfolio with Strong Financial Position
Positive
Aug 28, 2025

PureTech Health has reported significant progress in its diversified portfolio, with multiple programs moving towards late-stage development. The company has launched Celea Therapeutics and maintained a strong financial position, ensuring operational flexibility until 2028. Strategic priorities include advancing promising programs, strengthening UK capital market engagement, and disciplined capital allocation. The company is set to initiate a Phase 3 trial for deupirfenidone in 2026 and expects reduced operational expenses as responsibilities transition to external entities. Leadership changes and a search for new directors aim to enhance shareholder value.

The most recent analyst rating on (GB:PRTC) stock is a Hold with a £141.00 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
PureTech Health Advances Deupirfenidone in IPF Treatment
Positive
Aug 21, 2025

PureTech Health has showcased its development strategy at the 2025 IPF Summit, highlighting the Phase 2b ELEVATE IPF trial data for deupirfenidone, which is set to advance into Phase 3 trials. The company emphasizes a holistic approach to development, incorporating patient insights and sophisticated trial designs to potentially establish deupirfenidone as a new standard of care in IPF, with its newly launched entity, Celea Therapeutics, leading the effort.

The most recent analyst rating on (GB:PRTC) stock is a Hold with a £142.00 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Financial Disclosures
PureTech Health to Announce Half-Yearly Financial Results
Neutral
Aug 18, 2025

PureTech Health announced that it will release its half-yearly financial results for the first half of 2025 on August 28, 2025. The announcement will be accompanied by a presentation and conference call for analysts and shareholders, which indicates the company’s commitment to transparency and engagement with stakeholders. This release is significant for stakeholders as it provides insights into the company’s financial health and strategic direction.

The most recent analyst rating on (GB:PRTC) stock is a Buy with a £4.55 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Vedanta Biosciences Shifts Focus After VE202 Study Misses Endpoint
Neutral
Aug 13, 2025

Vedanta Biosciences, a PureTech Founded Entity, announced that its Phase 2 study of VE202 for ulcerative colitis did not meet its primary endpoint, though the treatment was well tolerated. Despite this setback, Vedanta will focus on its Phase 3 study of VE303 for preventing recurrent Clostridioides difficile infection, which has shown promising Phase 2 results. This strategic shift underscores Vedanta’s commitment to addressing unmet medical needs in gastrointestinal health, with potential implications for stakeholders as the company advances its pipeline.

The most recent analyst rating on (GB:PRTC) stock is a Buy with a £4.55 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Business Operations and StrategyExecutive/Board ChangesProduct-Related Announcements
PureTech Health Launches Celea Therapeutics to Revolutionize Respiratory Disease Treatment
Positive
Aug 12, 2025

PureTech Health has launched Celea Therapeutics, a new entity focused on transforming the treatment of respiratory diseases, with former Teva North America CEO Sven Dethlefs leading the initiative. Celea’s lead program, deupirfenidone (LYT-100), is a Phase 3-ready candidate aimed at treating idiopathic pulmonary fibrosis (IPF), a severe lung disease. The launch underscores PureTech’s commitment to advancing innovative therapies through focused structures, and the appointment of Dr. Dethlefs, with his extensive experience, is expected to drive the program’s success. The development of deupirfenidone, which has shown promising Phase 2b results, represents a significant opportunity in the IPF market, which is currently underserved by existing treatments.

The most recent analyst rating on (GB:PRTC) stock is a Buy with a £4.55 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Regulatory Filings and Compliance
PureTech Health Discloses Voting Rights and Share Capital Update
Neutral
Aug 1, 2025

PureTech Health announced its total voting rights and share capital as of July 31, 2025, with 241,316,327 voting rights available. This information is crucial for shareholders to determine their notification obligations under the FCA’s rules, reflecting PureTech’s commitment to transparency and regulatory compliance.

The most recent analyst rating on (GB:PRTC) stock is a Buy with a £455.00 price target. To see the full list of analyst forecasts on PureTech Health stock, see the GB:PRTC Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Sep 30, 2025