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Scancell Holdings
(LSE:SCLP)
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Rating:44Neutral
Price Target:
87.00 p
▲(804.37% Upside)
Action:Reiterated
Date:10/22/26
Overall score is held down primarily by weak financial performance (persistent losses, cash burn, and negative equity) and bearish technicals (downtrend despite oversold readings). The main offset is constructive clinical/regulatory momentum from the earnings call, but near-term funding risk and the long path to definitive Phase III data limit the overall score.
Positive Factors
Regulatory readiness
FDA clearance materially reduces a key development barrier by validating the proposed clinical and manufacturing package for Phase III. Acceptance of a surrogate endpoint also creates a potential accelerated-approval route, strengthening the program’s regulatory and commercial pathway over the next several years.
Negative Factors
Persistent operating losses
The absence of revenue and persistent operating losses show that the business has not yet established commercial earnings power. Negative gross profit in 2026 also highlights weak operating leverage, leaving future progress dependent on clinical success, partnerships or external capital.
Read all positive and negative factors
Positive Factors
Negative Factors
Regulatory readiness
FDA clearance materially reduces a key development barrier by validating the proposed clinical and manufacturing package for Phase III. Acceptance of a surrogate endpoint also creates a potential accelerated-approval route, strengthening the program’s regulatory and commercial pathway over the next several years.
Read all positive factors
Scancell Holdings (SCLP) vs. iShares MSCI United Kingdom ETF (EWC)
Market Cap
£109.10M
Dividend YieldN/A
Average Volume (3M)117.58K
Price to Earnings (P/E)―
Beta (1Y)-0.14
Revenue Growth-100.00%
EPS Growth-30.39%
CountryUK
Employees60
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-0.17
Shares Outstanding121,223,070
10 Day Avg. Volume90,431
30 Day Avg. Volume117,575
Financial Highlights & Ratios
PEG Ratio-0.24
Price to Book (P/B)-7.48
Price to Sales (P/S)0.00
P/FCF Ratio-13.76
Enterprise Value/Market CapN/A
Enterprise Value/RevenueN/A
Enterprise Value/Gross ProfitN/A
Enterprise Value/EbitdaN/A
Forecast
1Y Price TargetN/A
Price Target UpsideN/A
Rating ConsensusN/A
Number of Analyst Covering0
EPS Forecast (FY)-0.23
Revenue Forecast (FY)£2.31M
Scancell Holdings Business Overview & Revenue Model
Company Description
Scancell Holdings plc is a clinical-stage biopharmaceutical firm focused on discovering and developing innovative vaccine and antibody treatments. Its mission is to address significant unmet medical needs in both cancer and infectious diseases. Th...
Scancell Holdings Earnings Call Summary
Earnings Call Date:Jan 29, 2026
(Q2-2026)
| % Change Since: |
Next Earnings Date:Feb 04, 2027
Earnings Call Sentiment Positive
The call conveyed strong clinical and regulatory progress—most notably the FDA IND clearance, compelling PFS data (74% at 16 months with a 24% delta), validated manufacturing and delivery, and multiple pipeline and partnered value drivers (including up to $630M in Genmab milestones). The primary negatives are financial (no revenue, interim net loss, and a cash runway into H2 2026) and the long, blinded Phase III timeline to a registrational readout in H2 2029 which necessitates near-term financing or milestone receipts. On balance, the positive clinical/regulatory milestones and clear commercial pathway outweigh the funding and timing headwinds.Positive Updates
Strong Efficacy Signal for iSCIB1+ (PFS)
iSCIB1+ demonstrated progression-free survival (PFS) of 74% at 16 months in Phase II data; reported a 24% delta versus historic/real-world benchmarks (comparison with ipilimumab+nivolumab median PFS ~11.5 months). Company also reported a ~16% improvement for prior SCIB1 on overall survival versus the comparator in their dataset, and noted similarity in order of magnitude to published Moderna 5‑year follow-up data.
Negative Updates
No Revenues Reported in Period
There were no revenues in the interim period; revenue upside depends on future partnered milestones (Genmab) and commercial success.
Read all updates
Q2-2026 Updates
Positive
Negative
Strong Efficacy Signal for iSCIB1+ (PFS)
iSCIB1+ demonstrated progression-free survival (PFS) of 74% at 16 months in Phase II data; reported a 24% delta versus historic/real-world benchmarks (comparison with ipilimumab+nivolumab median PFS ~11.5 months). Company also reported a ~16% improvement for prior SCIB1 on overall survival versus the comparator in their dataset, and noted similarity in order of magnitude to published Moderna 5‑year follow-up data.
Read all positive updates
Company Guidance
Management guided that iSCIB1+—which showed 74% PFS at 16 months (a ~24 percentage‑point delta versus historic ipi/nivo data with median PFS ≈11.5 months) from a Phase II translational dataset of ~140 patients—will move to a registrational Phase III two‑arm study of ~230 patients per arm (~460 total) with an adaptive design, IND cleared by the FDA, a surrogate primary endpoint (enabling accelerated approval), plans to pursue Fast Track and a Breakthrough designation (decision timeline ~2–3 months) and a target readout/commercialization window in H2 2029; financially, H1 (6 months to 31 Oct 2025) R&D spend was $6.2m, admin costs £2.7m, operating loss £8.9m, net loss £5.7m, cash £8.6m (including a £3.0m R&D tax credit) giving runway into H2 2026, while management pursues partnering/financing (including up to $630m of potential Genmab milestones), expects Modi‑1 data in H1, anticipates further Genmab/SC129 milestones this year, and notes patent protection to 2041 plus scalable manufacturing and a PharmaJet needle‑free delivery partnership.Scancell Holdings Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
12
Very Negative
Cash Flow
24
Negative
| Breakdown | Apr 2026 | Apr 2025 | Apr 2024 | Oct 2023 | Apr 2022 |
|---|---|---|---|---|---|
Income Statement | |||||
| Total Revenue | 0.00 | 4.71M | 0.00 | 5.27M | 0.00 |
| Gross Profit | -672.00K | 3.59M | -966.00K | 4.75M | -740.00K |
| EBITDA | -16.75M | -12.71M | -7.06M | -12.19M | -3.75M |
| Net Income | -17.90M | -12.27M | -5.86M | -11.94M | -2.06M |
Balance Sheet | |||||
| Total Assets | 10.36M | 23.09M | 23.58M | 30.27M | 49.06M |
| Cash, Cash Equivalents and Short-Term Investments | 5.32M | 16.89M | 14.82M | 19.92M | 28.73M |
| Total Debt | 17.08M | 16.27M | 19.87M | 21.13M | 18.92M |
| Total Liabilities | 29.77M | 26.93M | 27.08M | 36.50M | 29.57M |
| Stockholders Equity | -19.41M | -3.83M | -3.50M | -6.23M | 18.11M |
Cash Flow | |||||
| Free Cash Flow | -10.56M | -6.12M | -15.84M | -8.34M | -8.55M |
| Operating Cash Flow | -10.56M | -6.11M | -15.66M | -8.14M | -7.80M |
| Investing Cash Flow | 356.00K | -1.54M | 178.00K | 81.00K | -741.00K |
| Financing Cash Flow | -1.35M | 9.73M | 10.39M | -746.00K | 46.08M |
Scancell Holdings Technical Analysis
Negative
9.62
Price Trends
95.63
Negative
120.64
Negative
134.16
Negative
Market Momentum
-1.78
Positive
27.32
Positive
27.71
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:SCLP, the sentiment is Negative. The current price of 9.62 is below the 20-day moving average (MA) of 93.11, below the 50-day MA of 95.63, and below the 200-day MA of 134.16, indicating a bearish trend. The MACD of -1.78 indicates Positive momentum. The RSI at 27.32 is Positive, neither overbought nor oversold. The STOCH value of 27.71 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for GB:SCLP.
Scancell Holdings Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
52 Neutral | £82.07M | -4.57 | -316.73% | ― | -56.10% | -16.77% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | £51.53M | -8.65 | -71.28% | ― | ― | 31.58% | |
47 Neutral | £23.05M | -4.53 | -284.01% | ― | ― | -105.65% | |
47 Neutral | £37.37M | 165.00 | 3.75% | ― | ― | ― | |
44 Neutral | £109.10M | -5.14 | 128.87% | ― | -100.00% | -30.39% | |
44 Neutral | £64.47M | -2.83 | -9999.00% | ― | 26.99% | 4.36% |
* Healthcare Sector Average
GB:SCLP
Scancell Holdings
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-6.50
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Scancell Holdings Corporate Events
Business Operations and StrategyDelistings and Listing ChangesM&A TransactionsShareholder MeetingsStock Split
Scancell clears share consolidation as it readies AIM trading and deal push
Positive
Oct 20, 2026
Scancell Holdings has confirmed that all resolutions at its latest general meeting were approved, paving the way for a share consolidation in which every 10 existing ordinary shares of 0.1 pence will be combined into one new ordinary share of 1 pe...
Financial DisclosuresShareholder MeetingsStock Split
Scancell Issues Shares Ahead of Consolidation and Publishes 2026 Annual Report
Neutral
Oct 15, 2026
Scancell Holdings has issued seven new ordinary shares to chief executive Dr Phil L’Huillier to ensure its share capital is exactly divisible by ten ahead of a planned share consolidation on a 10-for-1 basis. The new shares, which represent ...
Business Operations and StrategyDelistings and Listing ChangesFinancial DisclosuresM&A TransactionsPrivate Placements and FinancingProduct-Related Announcements
Scancell Bolsters Cancer Immunotherapy Push With Nasdaq Move and $75m Funding
Positive
Oct 9, 2026
Scancell reported progress across its immunotherapy pipeline, led by iSCIB1+, which has U.S. fast track status and regulatory clearance in the UK for a Phase 3 trial in unresectable Stage IIIB or IV melanoma, with around 550 patients to be enrolle...
Business Operations and StrategyDelistings and Listing ChangesM&A TransactionsPrivate Placements and FinancingShareholder MeetingsStock Split
Scancell Sets Vote on Neuphoria Merger and 10-for-1 Share Consolidation
Positive
Oct 2, 2026
Scancell Holdings has released a circular and called a general meeting for 20 October 2026 to seek shareholder approval for its planned merger with Neuphoria Therapeutics and associated financing for a registrational Phase 3 study of melanoma ther...
Business Operations and StrategyDelistings and Listing ChangesM&A TransactionsPrivate Placements and Financing
Scancell Secures Up to US$25m BlackRock Debt to Drive iSCIB1+ Phase 3
Positive
Sep 24, 2026
Scancell Holdings has secured a loan facility of up to US$25 million from funds managed by BlackRock, adding a structured layer of debt financing to support its planned Phase 3 development of lead melanoma candidate iSCIB1+ and complementing the p...
Business Operations and StrategyM&A Transactions
Scancell to Highlight Late-Stage Cancer Immunotherapy and U.S. Deal Plans at Wainwright Conference
Positive
Sep 3, 2026
Scancell Holdings will present at the H.C. Wainwright 28th Annual Global Investment Conference on September 16, 2026, with management hosting in-person investor meetings and providing a webcasted presentation accessible via the company’s web...
Business Operations and StrategyM&A TransactionsProduct-Related AnnouncementsRegulatory Filings and Compliance
Scancell Wins UK Green Light for Global Phase 3 Melanoma Trial of iSCIB1+
Positive
Aug 19, 2026
Scancell Holdings has secured UK Medicines and Healthcare Products Regulatory Agency authorization for a Phase 3 registrational trial of its lead DNA ImmunoBody, iSCIB1+, in advanced melanoma. The company operates as a late-stage clinical immuno-o...
Business Operations and StrategyExecutive/Board ChangesRegulatory Filings and Compliance
Scancell Extends CSO Share Option Exercise Period
Positive
Jul 31, 2026
Scancell Holdings, a clinical-stage biotech group, specialises in innovative cancer immunotherapies, including its DNA ImmunoBody and Moditope platforms, alongside a pipeline of GlyMab antibodies targeting tumour glycans through its GlyMab Therape...
Delistings and Listing ChangesPrivate Placements and FinancingRegulatory Filings and Compliance
Scancell Raises £15.7m After Oversubscribed Retail Offer and UK Placing
Positive
Jul 27, 2026
Scancell Holdings has confirmed that its retail offer, conducted via the Winterflood Retail Access Platform, was significantly oversubscribed and ultimately raised gross proceeds of £2.7 million at 9 pence per share, with allocations scaled b...
Business Operations and StrategyDelistings and Listing ChangesM&A TransactionsPrivate Placements and Financing
Scancell and Neuphoria in all-share merger backed by $89m financing for melanoma trial
Positive
Jul 24, 2026
Scancell Holdings and U.S.-based Neuphoria Therapeutics have agreed an all-share merger that will create a combined company operating under the Scancell name, with Scancell shareholders owning about 85.5% and Neuphoria investors 14.5%. The merged ...
Business Operations and StrategyDelistings and Listing ChangesPrivate Placements and Financing
Scancell upsizes oversubscribed £13m UK placing to extend funding runway
Positive
Jul 23, 2026
Scancell Holdings has upsized its UK equity placing, raising £13.0 million through the issue of 144,444,444 new shares, equivalent to about 13.9% of its existing share capital, after strong investor demand significantly oversubscribed the ori...
Business Operations and StrategyM&A TransactionsPrivate Placements and Financing
Scancell launches discounted UK share placing to fund Phase 3 melanoma trial
Neutral
Jul 23, 2026
Scancell Holdings plans to raise about $12 million (£9 million) through a non-pre-emptive UK placing of new ordinary shares at 9 pence, a 29.4% discount to the previous close, targeting new and existing institutional investors. Alongside this...
Business Operations and StrategyPrivate Placements and Financing
Scancell launches retail offer and placing to extend cash runway into 2027
Neutral
Jul 23, 2026
Scancell Holdings has launched a retail offer via the Winterflood Retail Access Platform to raise up to £2.3 million through the issue of around 25 million new shares at 9 pence each, alongside a previously announced UK placing targeting abou...
Business Operations and StrategyDelistings and Listing ChangesM&A TransactionsPrivate Placements and FinancingStock Split
Scancell to Merge with Neuphoria and Secure Up to $89m for Phase 3 Melanoma Trial
Positive
Jul 23, 2026
Scancell Holdings and Neuphoria Therapeutics have agreed an all-share merger that will create a combined immuno-oncology company operating under the Scancell name and listed on both AIM and Nasdaq. Existing Scancell shareholders are expected to ow...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.