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BridgeBio Pharma Inc (BBIO)
NASDAQ:BBIO
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BridgeBio Pharma (BBIO) AI Stock Analysis

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BBIO

BridgeBio Pharma

(NASDAQ:BBIO)

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Neutral 55 (OpenAI - 4o)
Rating:55Neutral
Price Target:
$68.00
▲(7.31% Upside)
BridgeBio Pharma's overall stock score is driven by strong earnings call results and technical momentum, offset by financial instability and poor valuation metrics. The company's growth potential is evident, but significant risks remain due to high leverage and cash flow challenges.
Positive Factors
Revenue Growth
The substantial revenue growth indicates strong market acceptance and successful commercialization of products, supporting long-term business expansion.
Pipeline Progress
Advancing multiple late-stage trials enhances future revenue potential and strengthens the company's competitive position in the biotech sector.
Strong Cash Position
A robust cash position provides financial flexibility for strategic investments and R&D, crucial for sustaining long-term growth and innovation.
Negative Factors
Profitability Challenges
Persistent profitability issues can hinder reinvestment and growth, posing a risk to the company's long-term financial health and shareholder value.
High Leverage
Excessive leverage increases financial risk and limits operational flexibility, potentially impacting the company's ability to navigate economic downturns.
Increased Operating Costs
Rising operating costs can pressure margins and reduce profitability, challenging the company's ability to maintain cost efficiency over time.

BridgeBio Pharma (BBIO) vs. SPDR S&P 500 ETF (SPY)

BridgeBio Pharma Business Overview & Revenue Model

Company DescriptionBridgeBio Pharma (BBIO) is a biotechnology company focused on developing innovative therapeutics for genetic diseases and cancers. The company operates primarily in the pharmaceutical sector, leveraging advanced genetic insights to identify and develop targeted therapies. BridgeBio specializes in creating treatments that address the underlying genetic causes of diseases, with a robust pipeline of product candidates across various stages of clinical development.
How the Company Makes MoneyBridgeBio Pharma generates revenue primarily through the development and commercialization of its therapeutic products. The company earns money through product sales once its therapies receive regulatory approval and are launched in the market. Additionally, BridgeBio may engage in partnerships and collaborations with larger pharmaceutical companies, which can provide upfront payments, milestone payments, and royalties on future sales. These strategic alliances can enhance revenue streams and provide necessary funding for ongoing research and development. Furthermore, BridgeBio may also receive grant funding for specific projects, contributing to its overall earnings.

BridgeBio Pharma Key Performance Indicators (KPIs)

Any
Any
Revenue by Segment
Revenue by Segment
Chart Insights
Data provided by:Main Street Data

BridgeBio Pharma Earnings Call Summary

Earnings Call Date:Oct 29, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 19, 2026
Earnings Call Sentiment Positive
The earnings call showcased positive developments with successful Phase III trial results and strong financial performance. However, challenges such as market access competition and increased operating expenses were noted.
Q3-2025 Updates
Positive Updates
Successful Phase III Trials
Announced two successful Phase III trials: FORTIFY trial of BBP-418 in limb-girdle muscular dystrophy type 2i and CALIBRATE trial of encaleret in autosomal dominant hypocalcemia type 1, both exceeding expectations.
Attruby's Market Performance
Delivered 5,259 unique patient prescriptions to 1,355 unique healthcare providers, generating $108.1 million in net product sales this quarter, with a goal of achieving a 30-35% market share.
Expansion and Growth Strategy
Continued expansion efforts with Beyonttra in Europe and plans to leverage real-world evidence studies. Preparing for potential new launches in the pipeline, including encaleret, BBP-418, and infigratinib.
Strong Financial Position
Reported $120.7 million in total revenues for Q3 2025 and ended the quarter with $645.9 million in cash, cash equivalents, and marketable securities.
Negative Updates
Challenges with Market Access
Concerns over Pfizer matching the 28-day free trial with VYNDAMAX and the impact of potential TAF generic drugs on Attruby's market position.
High Operating Expenses
Operating expenses increased by $65.4 million, driven primarily by a $68.8 million increase in SG&A expenses.
Company Guidance
During BridgeBio Pharma's Third Quarter 2025 Earnings Call, the company provided several key metrics and updates. Attruby, their core product, achieved significant commercial success, delivering 5,259 unique patient prescriptions to 1,355 healthcare providers and generating $108.1 million in net product sales. The company aims to achieve a 30-35% market share by volume. BridgeBio also announced impressive Phase III results for its pipeline candidates, BBP-418 and encaleret, reporting primary endpoint success and normalization of key biomarkers, respectively. Financially, the company reported total revenues of $120.7 million for the quarter, a significant increase from the previous year, and ended the quarter with a strong cash position of $645.9 million. Looking ahead, BridgeBio anticipates further growth from its late-stage pipeline, including a potential readout for infigratinib in 2026, and continues to expand its commercial and clinical efforts globally.

BridgeBio Pharma Financial Statement Overview

Summary
BridgeBio Pharma demonstrates strong revenue growth but faces significant profitability and financial stability challenges. The high gross profit margin is a positive indicator, but negative net income and high leverage pose risks. Cash flow management needs improvement to support sustainable growth.
Income Statement
45
Neutral
BridgeBio Pharma shows strong revenue growth with a 44.69% increase in TTM, indicating positive momentum. However, the company faces significant challenges with profitability, as evidenced by negative net profit margins and EBIT margins. The gross profit margin remains high at 96.80%, suggesting efficient cost management at the gross level, but overall profitability is hampered by high operating expenses.
Balance Sheet
30
Negative
The balance sheet reveals a concerning financial structure with negative stockholders' equity and a high debt-to-equity ratio of -1.50 in TTM, indicating financial instability. Return on equity is positive at 50.71%, but this is due to the negative equity base. The equity ratio is negative, highlighting potential risks in financial health and leverage.
Cash Flow
40
Negative
Cash flow analysis shows a decline in free cash flow growth by -11.53% in TTM, reflecting cash management challenges. The operating cash flow to net income ratio is negative, indicating cash flow issues relative to earnings. However, the free cash flow to net income ratio is slightly above 1, suggesting some alignment between cash flow and reported earnings.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue353.78M221.90M9.30M77.65M69.72M8.25M
Gross Profit338.84M218.02M6.86M74.21M66.60M8.25M
EBITDA-677.28M-436.83M-565.47M-397.44M-533.83M-467.38M
Net Income-797.12M-535.76M-643.20M-481.18M-562.54M-448.72M
Balance Sheet
Total Assets998.25M919.34M546.38M623.04M1.01B703.59M
Cash, Cash Equivalents and Short-Term Investments645.94M681.10M434.88M428.27M787.51M607.09M
Total Debt8.72M1.73B1.74B1.72B1.73B495.79M
Total Liabilities2.92B2.38B1.89B1.87B1.88B595.70M
Stockholders Equity-1.92B-1.46B-1.35B-1.25B-870.41M57.91M
Cash Flow
Free Cash Flow-589.12M-521.66M-529.03M-425.81M-546.18M-407.23M
Operating Cash Flow-584.82M-520.73M-527.72M-419.49M-497.93M-399.71M
Investing Cash Flow-13.37M60.78M54.03M453.15M-200.83M-52.99M
Financing Cash Flow835.41M748.46M451.54M-13.13M736.45M447.19M

BridgeBio Pharma Technical Analysis

Technical Analysis Sentiment
Positive
Last Price63.37
Price Trends
50DMA
53.61
Positive
100DMA
49.50
Positive
200DMA
42.01
Positive
Market Momentum
MACD
2.74
Negative
RSI
66.43
Neutral
STOCH
80.77
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BBIO, the sentiment is Positive. The current price of 63.37 is above the 20-day moving average (MA) of 56.81, above the 50-day MA of 53.61, and above the 200-day MA of 42.01, indicating a bullish trend. The MACD of 2.74 indicates Negative momentum. The RSI at 66.43 is Neutral, neither overbought nor oversold. The STOCH value of 80.77 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for BBIO.

BridgeBio Pharma Risk Analysis

BridgeBio Pharma disclosed 103 risk factors in its most recent earnings report. BridgeBio Pharma reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

BridgeBio Pharma Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
$10.48B18.6829.00%10.73%81.66%
$9.97B19.459.07%12.31%60.21%
$12.01B-39.99%20.42%33.94%
$9.53B-33.28-36.30%3421.98%49.62%
$12.74B7.62%-55.29%
$7.86B-0.30-43.30%2.27%22.53%-2.21%
$10.99B-27.50%-38.95%51.07%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BBIO
BridgeBio Pharma
63.37
37.89
148.70%
BMRN
BioMarin Pharmaceutical
51.91
-14.69
-22.06%
EXEL
Exelixis
38.94
4.82
14.13%
IONS
Ionis Pharmaceuticals
74.17
35.41
91.36%
MDGL
Madrigal Pharmaceuticals
427.52
107.94
33.78%
MRNA
Moderna
28.14
-26.49
-48.49%

BridgeBio Pharma Corporate Events

BridgeBio Pharma Reports Strong Q3 2025 Results
Oct 30, 2025

BridgeBio Pharma, Inc. is a biopharmaceutical company focused on developing transformative medicines for genetic diseases, leveraging a robust pipeline that spans from early-stage research to advanced clinical trials.

Business Operations and StrategyProduct-Related Announcements
BridgeBio Pharma Reports Positive Phase 3 Study Results
Positive
Oct 29, 2025

BridgeBio Pharma announced positive results from its Phase 3 CALIBRATE study of encaleret for treating autosomal dominant hypocalcemia type 1 (ADH1) on October 29, 2025. The study met all primary and key secondary endpoints, showing significant improvements in calcium and parathyroid hormone levels compared to conventional therapy. Encaleret was well-tolerated, with plans for a New Drug Application submission in 2026. The results suggest encaleret could become a new standard of care for ADH1, potentially impacting the lives of patients with this genetic condition.

The most recent analyst rating on (BBIO) stock is a Buy with a $90.00 price target. To see the full list of analyst forecasts on BridgeBio Pharma stock, see the BBIO Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
BridgeBio Pharma Announces Positive Phase 3 Study Results
Positive
Oct 27, 2025

On October 27, 2025, BridgeBio Pharma announced positive results from its Phase 3 FORTIFY study of BBP-418, a treatment for limb-girdle muscular dystrophy type 2I/R9 (LGMD2I/R9). The study showed significant improvements in motor and pulmonary functions, with a well-tolerated safety profile, marking a potential breakthrough for a disease with no specific treatments. The company plans to file for FDA approval in the first half of 2026, which could position BBP-418 as the first therapy to alter the course of this debilitating condition.

The most recent analyst rating on (BBIO) stock is a Buy with a $58.00 price target. To see the full list of analyst forecasts on BridgeBio Pharma stock, see the BBIO Stock Forecast page.

BridgeBio Pharma’s Earnings Call Highlights Strong Growth
Aug 13, 2025

BridgeBio Pharma’s latest earnings call reflects a predominantly positive sentiment, highlighting strong performance and significant growth prospects. The company showcased impressive revenue growth driven by the successful launch of Attruby, although challenges such as increased operating expenses and competitive pressures were also acknowledged.

BridgeBio Pharma Reports Strong Q2 2025 Results
Aug 6, 2025

BridgeBio Pharma, Inc. is a biopharmaceutical company specializing in the development of transformative medicines for genetic diseases, with a diverse pipeline ranging from early-stage research to advanced clinical trials.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 30, 2025