Competitive PressureShare weakness is likely also driven by PKR activator competitor readout from Novo Nordisk, which demonstrated comparable performance in VOC reduction and hemoglobin response.
Regulatory Approval ChallengesThe withdrawal of Oxbryta increases the likelihood that regulators will need to see a definitive clinical benefit as a condition for approval, raising the regulatory bar.
Regulatory ConcernsThe updated label for Pyrukynd includes a warning for liver injury, which has been an overhang for AGIO shares, contributing to a significant decline in stock value.