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PSIL

AdvisorShares Psychedelics ETF (PSIL)

Rating:44Neutral
Price Target:$20.50â–²(2.14% Upside)

PSIL’s rating suggests it is a specialized, higher-risk ETF focused on psychedelics and related biotech, with quality partially supported by established pharma names like Neurocrine, Johnson & Johnson, Eli Lilly, and AbbVie that bring stronger financial performance and more stable growth prospects. However, large positions in early-stage biotech companies such as Mind Medicine, Compass Pathways, Cybin, Relmada, and Bright Minds Biosciences, all facing zero or minimal revenue and ongoing losses, weigh on the fund’s overall quality. The main risk is its heavy concentration in speculative, clinical-stage psychedelics companies, which makes the ETF more volatile and dependent on successful trial outcomes and future financing.

Positive Factors
Strong Year-to-Date PerformanceThe ETF has delivered strong gains so far this year, showing solid momentum despite recent short-term pullbacks.
High-Performing Top HoldingsSeveral of the largest positions, including Definium Therapeutics, COMPASS Pathways, and major pharma names like Eli Lilly and AbbVie, have shown strong or steady performance that supports the fund.
Focused Exposure to Healthcare and PsychedelicsThe fund is heavily invested in healthcare and psychedelics-related companies, giving investors targeted access to a specialized growth theme.
Negative Factors
High Expense RatioThe ETF charges a relatively high fee, which can eat into investor returns over time compared with lower-cost funds.
Short-Term Performance WeaknessRecent one-month and three-month returns have been weak, which may signal higher volatility and near-term pressure on the fund’s price.
Concentrated and Risky HoldingsA small group of specialized healthcare and psychedelics stocks makes up a large share of the portfolio, and some key holdings like Relmada Therapeutics and Bright Minds Biosciences have shown weak performance, increasing risk.

PSIL vs. SPDR S&P 500 ETF (SPY)

-10%0%10%20%30%40%50%60%70%SPY+14.30%PSIL+21.90%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
AUM
43.26M
Region
Global
Expense Ratio
1.00%
Beta
0.90
Issuer
AdvisorShares
Inception Date
Sep 15, 2021
Dividend Yield
9.36%
Asset Class
Equity
Index Tracked
No Underlying Index

PSIL Summary

The AdvisorShares Psychedelics ETF (PSIL) is a health care fund that focuses on companies developing psychedelic-based treatments for mental health issues like depression and anxiety. It doesn’t track a traditional index, but instead follows the theme of pharma, biotech, and life sciences firms working on these new therapies. Well-known holdings include Eli Lilly and Johnson & Johnson, alongside smaller, more experimental drug makers. Someone might invest for the potential long-term growth of new medical breakthroughs and added diversification. However, this ETF is risky because it holds many young, volatile biotech companies, so its price can swing sharply up or down.

How much will it cost me?

This ETF has an expense ratio of 1.00%, which means you’ll pay about $10 per year for every $1,000 you invest. That’s higher than the average ETF because it’s actively managed and focuses on a very specialized niche in psychedelics and biotech, which typically costs more to run.

What would affect this ETF?

This ETF could benefit if mental health treatments using psychedelics gain wider medical approval, large drug companies keep investing in this area, and global health care spending remains strong. On the other hand, it could be hurt by strict or changing drug regulations, setbacks in clinical trials, shifts in government health policies, or a downturn in biotech stocks worldwide.

PSIL Top 10 Holdings

PSIL is a niche, globally focused health care ETF that leans heavily into early-stage psychedelic drug developers, with COMPASS Pathways and Definium Therapeutics setting the tone. COMPASS has been mixed lately, while Definium is rising this year but still volatile, reflecting the boom-or-bust nature of the space. Relmada and Bright Minds are clearly lagging, acting like weights on the portfolio as their high-risk pipelines struggle to gain traction. Big pharma names like Eli Lilly and Johnson & Johnson provide a steadier backbone, helping balance out the fund’s speculative core.

PSIL top ten holdings
NameCompany NameWeight %Market ValueMarket CapYearly GainOverall Rating
DFTXDFTXDefinium Therapeutics12.12%$5.28M$4.74B176.20%40Neutral
CMPSCMPSCOMPASS Pathways10.35%$4.50M$1.31B63.16%47Neutral
TSE:CYBNTSE:CYBNCybin8.20%$3.57M――37Underperform
LLYLLYEli Lilly & Co6.47%$2.82M$1.35T45.38%72Outperform
RLMDRLMDRelmada Therapeutics6.54%$2.85M$455.48M34.65%41Neutral
ABBVABBVAbbVie5.74%$2.50M$519.48B31.00%66Neutral
NBIXNBIXNeurocrine5.99%$2.61M$17.12B18.41%80Outperform
SPTXSPTXSeaport Therapeutics, Inc.5.11%$2.22M$1.18B7.41%――
STIMSTIMNeuronetics3.72%$1.62M$156.23M-26.36%41Neutral
JNJJNJJohnson & Johnson4.66%$2.03M$675.92B44.67%78Outperform

PSIL Technical Analysis

Technical Analysis SentimentNegative
Last Price20.07

Price Trends

50DMA22.12Negative
100DMA23.21Negative
200DMA20.82Negative

Market Momentum

MACD-0.62Negative
RSI44.73Neutral
STOCH45.17Neutral

Evaluating momentum and price trends is crucial in ETF analysis to make informed investment decisions. For PSIL, the sentiment is Negative. The current price of 20.07 is below the 20-day moving average (MA) of 20.33, below the 50-day MA of 22.12, and below the 200-day MA of 20.82, indicating a bearish trend. The MACD of -0.62 indicates Negative momentum. The RSI at 44.73 is Neutral, neither overbought nor oversold. The STOCH value of 45.17 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PSIL.

PSIL Peer Comparison

Comparison Results

PSIL against its peer funds
NamePricePrice TargetAUMExpense RatioOverall Rating
PSILPSIL$20.07$20.50(2.14% Upside)$43.26M1.00%44Neutral
HRTSHRTS$39.41$45.92(16.52% Upside)$58.37M0.75%67Neutral
OZEMOZEM$31.73$49.19(55.02% Upside)$58.23M0.59%57Neutral
MEDIMEDI$36.25$46.16(27.32% Upside)$44.19M0.80%62Neutral
TMEDTMED$35.44$58.28(64.45% Upside)$39.43M0.44%59Neutral
FMEDFMED$32.76―$30.30M0.50%59Neutral

Performance Comparison

0%20%40%60%PSILHRTSOZEMMEDITMEDFMEDDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
PSIL and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
PSILAdvisorShares Psychedelics ETF20.074.0525.27%
HRTSTema Cardiovascular and Metabolic ETF39.415.5416.35%
OZEMRoundhill GLP-1 & Weight Loss ETF31.730.200.64%
MEDIHarbor Health Care ETF36.255.0616.22%
TMEDT. Rowe Price Health Care ETF35.446.4522.25%
FMEDFidelity Disruptive Medicine ETF32.765.6320.77%
Glossary
BuyAn ETF rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF is likely to deliver higher returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldAn ETF rated as a "Hold" s expected to perform in line with the overall market or a specific benchmark. This rating indicates that the ETF is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellAn ETF rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF may deliver lower returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer

This AI Analyst ETF Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in ETFs carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.