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Spyre Therapeutics (SYRE)
NASDAQ:SYRE
US Market
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Spyre Therapeutics (SYRE) Stock Statistics & Valuation Metrics

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Total Valuation

Spyre Therapeutics has a market cap or net worth of $7.91B. The enterprise value is $6.52B.
Market Cap$7.91B
Enterprise Value$6.52B

Share Statistics

Spyre Therapeutics has 92,291,410 shares outstanding. The number of shares has decreased by -2.65% in one year.
Shares Outstanding92,291,410
Owned by Insiders1.65%
Owned by Institutions44.44%

Financial Efficiency

Spyre Therapeutics’s return on equity (ROE) is -0.22 and return on invested capital (ROIC) is -29.14%.
Return on Equity (ROE)-0.22
Return on Assets (ROA)-0.20
Return on Invested Capital (ROIC)-29.14%
Return on Capital Employed (ROCE)-0.29
Revenue Per Employee0.00
Profits Per Employee-1.24M
Employee Count125
Asset Turnover0.00
Inventory Turnover0.00

Valuation Ratios

The current PE Ratio of Spyre Therapeutics is ―. Spyre Therapeutics’s PEG ratio is 0.44.
PE Ratio―
PS Ratio0.00
PB Ratio2.93
Price to FCF-12.40
Price to Operating Cash Flow-34.83
PEG Ratio0.44

Income Statement

In the last 12 months, Spyre Therapeutics had revenue of 0.00 and earned -155.20M in profits. Earnings per share was -1.98.
Revenue0.00
Gross Profit-171.65M
Operating Income-209.56M
Pretax Income-155.22M
Net Income-155.20M
EBITDA-209.56M
Earnings Per Share (EPS)-1.98

Cash Flow

In the last 12 months, operating cash flow was -208.94M and capital expenditures 0.00, giving a free cash flow of -208.94M billion.
Operating Cash Flow-208.94M
Free Cash Flow-208.94M
Free Cash Flow per Share-2.26

Dividends & Yields

Spyre Therapeutics pays an annual dividend of ―, resulting in a dividend yield of ―
Dividend Per Share―
Dividend Yield―
Payout RatioN/A
Free Cash Flow Yield―
Earnings Yield―

Stock Price Statistics

Beta1.91
52-Week Price Change354.02%
50-Day Moving Average94.33
200-Day Moving Average68.89
Relative Strength Index (RSI)45.29
Average Volume (3m)1.42M

Important Dates

Spyre Therapeutics upcoming earnings date is Nov 5, 2026, TBA (Confirmed).
Last Earnings DateAug 4, 2026
Next Earnings DateNov 5, 2026
Ex-Dividend Date―

Financial Position

Spyre Therapeutics as a current ratio of 13.25, with Debt / Equity ratio of 0.00%
Current Ratio13.25
Quick Ratio13.25
Debt to Market Cap0.00
Net Debt to EBITDA0.41
Interest Coverage Ratio0.00

Taxes

In the past 12 months, Spyre Therapeutics has paid -15.00K in taxes.
Income Tax-15.00K
Effective Tax Rate<0.01

Enterprise Valuation

Spyre Therapeutics EV to EBITDA ratio is -9.60, with an EV/FCF ratio of -11.89.
EV to Sales0.00
EV to EBITDA-9.60
EV to Free Cash Flow-11.89
EV to Operating Cash Flow-11.89

Balance Sheet

Spyre Therapeutics has $1.15B in cash and marketable securities with $0.00 in debt, giving a net cash position of $1.15B billion.
Cash & Marketable Securities$1.15B
Total Debt$0.00
Net Cash$1.15B
Net Cash Per Share$12.41
Tangible Book Value Per Share$11.17

Margins

Gross margin is 0.00%, with operating margin of 0.00%, and net profit margin of 0.00%.
Gross Margin0.00%
Operating Margin0.00%
Pretax Margin0.00%
Net Profit Margin0.00%
EBITDA Margin0.00%
EBIT Margin0.00%

Analyst Forecast

The average price target for Spyre Therapeutics is $122.23, which is 11.43% higher than the current price. The consensus rating is Strong Buy
Price Target$122.23
Price Target Upside13.85% Upside
Analyst ConsensusStrong Buy
Analyst Count14
Revenue Growth Forecast―
EPS Growth Forecast28.51%

Scores

Smart Score8
AI Score―