Spero Therapeutics stock analysis
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Spero Therapeutics (SPRO) Stock Price & Analysis
SPRO Stock Chart & Stats
- Day’s Range
- $1.01 - $1.05
- 52-Week Range
- $0.96 - $3.08
- Previous Close
- $1.01
- Volume
- N/A
- Average Volume (3M)
- 420.99K
- Market Cap
- $58.82M
- Enterprise Value
- $79.38M
- Total Cash (Recent Filing)
- $50.77M
- Total Debt (Recent Filing)
- $2.04M
- Price to Earnings (P/E)
- 7.3
- Beta
- 1.79
- Next Earnings
- Nov 16, 2026 (Est.)
- EPS Estimate
- -0.47
- Last Dividend Ex-Date
- Sep 16, 2015
- Dividend Yield
- N/A
Bulls Say, Bears Say
Bulls Say
Approved Utebzi With GSK Commercialization
Utebzi approval converts a key antibiotic program into a commercial opportunity, while GSK’s exclusive rights provide an experienced commercialization partner. Expected U.S. availability in 2H 2026 creates a durable pathway to milestone and royalty income.
Extended Funding Runway
The nondilutive financing materially extends Spero’s operating runway without immediate equity issuance, supporting continued development and strategic execution. Funding visibility through 2H 2029 reduces near-term liquidity pressure and allows management to pursue milestones from a stronger position.
Conservatively Levered Balance Sheet
Very low debt relative to equity limits balance-sheet risk and preserves financial flexibility as Spero advances its pipeline. Positive return on equity indicates that recent profitability has not depended heavily on leverage, supporting greater resilience across funding and development cycles.
Bears Say
Revenue Interruption And Wider Quarterly Loss
The sharp quarterly revenue decline and wider loss show that reported financial performance remains highly dependent on collaboration revenue and milestone timing. Until recurring commercial or royalty receipts develop, earnings visibility and the durability of current profitability remain uncertain.
Dependence On Utebzi Royalty Streams
Although the financing is nonrecourse, its principal and interest payments depend on Utebzi’s future commercial performance and milestone generation. The 10% annual rate also creates a substantial fixed claim on proceeds, increasing execution sensitivity around launch and demand.
Unproven Early-stage SP001 Program
SP001 offers strategic pipeline potential but remains clinically unproven, with a small planned Phase II study that may provide limited evidence of efficacy or durability. Realizing its contingent value will require successful trials, regulatory progress, and effective commercial execution.
Spero Therapeutics News
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Spero Therapeutics Stock Smart Score
Company Description
Spero Therapeutics
Spero Therapeutics, Inc. is a biopharmaceutical firm in the clinical development stage, primarily focused on discovering, advancing, and commercializing innovative treatments for multi-drug resistant (MDR) bacterial infections and rare diseases within the United States. The company's pipeline includes several key therapeutic candidates: tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic designed to address complicated urinary tract infections (cUTIs), including pyelonephritis, in adult patients. SPR206, an intravenously administered agent specifically developed to combat MDR Gram-negative bacterial infections in hospital environments. SPR720, an oral antibiotic targeting non-tuberculous mycobacterial (NTM) pulmonary disease. Spero Therapeutics has also forged several strategic alliances: A licensing agreement with Meiji Seika Pharma Co., Ltd. supports the ongoing development of tebipenem HBr. A separate licensing deal with Everest Medicines grants rights for the development, manufacturing, and commercialization of SPR206 across Greater China, South Korea, and various Southeast Asian nations. The company collaborates with the Bill & Melinda Gates Medical Research Institute to advance SPR720 for treating lung infections caused by Mycobacterium tuberculosis. Furthermore, a licensing agreement with Vertex Pharmaceuticals Incorporated covers patents associated with SPR720 and its active metabolite, SPR719. Founded in 2013, Spero Therapeutics maintains its corporate headquarters in Cambridge, Massachusetts.
- Sector
- Healthcare
- Industry
- Biotechnology
- CEO
- Esther Rajavelu
- Employees
- 25
- Website
- sperotherapeutics.com
- Address
- 675 Massachusetts Avenue, Cambridge, MA, 02139, US
Spero Therapeutics (SPRO) Earnings & Revenues
SPRO Earnings Call
Earnings Call SentimentPositive
The call conveyed a strategic positive shift: an important product approval (Utebzi), a high-value in-license (SP001) with a clear development plan in IgG4-RD, a non-dilutive $105M financing that extends runway into H2 2029, and a strengthened clinical leadership team. Offsetting these positives are an absence of current revenue (Q2 2026 revenue $0 vs $14.2M prior year), a wider net loss and increased loss per share, dependence on GSK royalty/milestone streams to service the financing, and SP001 remaining early-stage with a small planned Phase II. On balance, management’s actions materially de-risk near-term funding and position the company for an immunology strategy, but meaningful clinical and commercial execution risks remain.
View all SPRO earnings summariesSPRO Stock 12 Month Forecast
Average Price Target
Technical Analysis
Overall Consensus
| Indicator | Bullish | Neutral | Bearish |
|---|---|---|---|
| Overall Consensus | 4 | 4 | 14 |
| Technical Analysis | 4 | 4 | 2 |
| Moving Averages | 0 | 0 | 12 |












