Clinical ProgressKorro's Serpina1 RNA editor KRRO-110 in AATD continues to progress with over 80% enrollment in the 36 healthy volunteer placebo-controlled portion of the part 1 single-ascending-dose (SAD) portion.
Commercial OpportunitiesThe lead program KRRO-110 aims to treat AATD and presents a significant commercial opportunity due to high unmet need and lack of approved disease-modifying therapies.
Safety ProfileKRRO-110 dosing was safely completed in ~5 SAD HV cohorts, further derisking KRRO-110 LNP safety, given that the assessed doses are likely therapeutically active in AATD patients.