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Protagonist Therapeutics
(NASDAQ:PTGX)
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Rating:59Neutral
Price Target:
$146.00
▲(37.76% Upside)
Action:Reiterated
Date:06/19/26
The score is primarily held back by weak TTM profitability and significant cash burn despite a strong, low-leverage balance sheet. Technicals are supportive with strong trend/momentum, while valuation remains pressured due to negative earnings and no dividend support. Corporate events are a small positive for governance continuity.
Positive Factors
Balance Sheet Strength
A conservative capital structure with minimal debt and sizable equity provides durable funding optionality for multi-year R&D programs. It reduces near-term refinancing pressure, enables prioritized clinical investments, and gives management flexibility to absorb development timing variability.
Negative Factors
Renewed Cash Burn
Sustained, material negative operating and free cash flow increases reliance on the balance sheet and external financing to fund R&D. Over multiple quarters this erodes runway, forces program prioritization, and elevates dilution and execution risk if cash burn is not arrested or financed on favorable terms.
Read all positive and negative factors
Positive Factors
Negative Factors
Balance Sheet Strength
A conservative capital structure with minimal debt and sizable equity provides durable funding optionality for multi-year R&D programs. It reduces near-term refinancing pressure, enables prioritized clinical investments, and gives management flexibility to absorb development timing variability.
Read all positive factors
Protagonist Therapeutics (PTGX) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$9.01B
Dividend YieldN/A
Average Volume (3M)771.92K
Price to Earnings (P/E)―
Beta (1Y)0.04
Revenue Growth-64.36%
EPS Growth-302.09%
CountryUS
Employees124
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-1.80
Shares Outstanding64,311,370
10 Day Avg. Volume932,045
30 Day Avg. Volume771,918
Financial Highlights & Ratios
PEG Ratio0.29
Price to Book (P/B)9.03
Price to Sales (P/S)120.66
P/FCF Ratio99.01
Enterprise Value/Market Cap0.78
Enterprise Value/Revenue94.28
Enterprise Value/Gross Profit94.80
Enterprise Value/Ebitda-61.29
Forecast
1Y Price Target
$121.00Price Target Upside14.17% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering9
EPS Forecast (FY)3.98
Revenue Forecast (FY)$504.06M
Protagonist Therapeutics Business Overview & Revenue Model
Company Description
Protagonist Therapeutics, Inc. is a biopharmaceutical firm dedicated to discovering and advancing peptide-based therapies. Their research primarily focuses on treatments for hematological and blood conditions, as well as inflammatory and immune-me...
How the Company Makes Money
Protagonist Therapeutics does not sell approved commercial products and therefore primarily generates revenue from collaboration-related payments and other income tied to its partnering activities. Key revenue streams include: (1) upfront payments...
Protagonist Therapeutics Financial Statement Overview
Summary
Income Statement
41
Neutral
Balance Sheet
78
Positive
Cash Flow
38
Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 74.06M | 46.02M | 434.43M | 60.00M | 26.58M | 27.36M |
| Gross Profit | 73.66M | 44.79M | 434.43M | 60.00M | 26.58M | 27.36M |
| EBITDA | -113.93M | -128.09M | 280.23M | -75.64M | -124.02M | -122.78M |
| Net Income | -114.71M | -130.15M | 275.19M | -78.95M | -127.39M | -125.55M |
Balance Sheet | ||||||
| Total Assets | 697.46M | 669.89M | 744.73M | 357.95M | 247.93M | 347.69M |
| Cash, Cash Equivalents and Short-Term Investments | 547.79M | 567.36M | 418.91M | 341.62M | 237.35M | 326.90M |
| Total Debt | 9.78M | 10.32M | 10.87M | 1.14M | 3.66M | 5.86M |
| Total Liabilities | 41.99M | 55.19M | 69.43M | 21.27M | 32.32M | 47.67M |
| Stockholders Equity | 655.47M | 614.71M | 675.29M | 336.68M | 215.61M | 300.02M |
Cash Flow | ||||||
| Free Cash Flow | -116.31M | 56.08M | 182.80M | -70.84M | -108.93M | -108.97M |
| Operating Cash Flow | -116.64M | 57.67M | 184.15M | -70.24M | -108.14M | -107.86M |
| Investing Cash Flow | 135.96M | -49.33M | -299.48M | -39.26M | 91.47M | -15.86M |
| Financing Cash Flow | 34.80M | 22.86M | 25.85M | 170.48M | 18.84M | 129.92M |
Protagonist Therapeutics Technical Analysis
Positive
105.98
Price Trends
108.57
Positive
102.80
Positive
91.91
Positive
Market Momentum
8.74
Negative
76.61
Negative
93.14
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PTGX, the sentiment is Positive. The current price of 105.98 is below the 20-day moving average (MA) of 121.22, below the 50-day MA of 108.57, and above the 200-day MA of 91.91, indicating a bullish trend. The MACD of 8.74 indicates Negative momentum. The RSI at 76.61 is Negative, neither overbought nor oversold. The STOCH value of 93.14 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PTGX.
Protagonist Therapeutics Risk Analysis
Protagonist Therapeutics disclosed 58 risk factors in its most recent earnings report. Protagonist Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Protagonist Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
70 Outperform | $2.12B | 13.28 | 38.97% | ― | 10.99% | -20.91% | |
59 Neutral | $9.01B | ― | -17.76% | ― | -64.36% | -302.09% | |
56 Neutral | $7.84B | -9.44 | -289.33% | ― | 50.19% | -742.29% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
45 Neutral | $2.22B | -11.92 | -24.29% | ― | 8.57% | 35.12% | |
40 Underperform | $1.65B | -9.65 | -123.61% | ― | -41.19% | -159.09% |
* Healthcare Sector Average
PTGX
Protagonist Therapeutics
137.64
84.82
160.58%
ADMA
ADMA Biologics
9.27
-9.20
-49.81%
ZLAB
Zai Lab
19.98
-14.10
-41.37%
MIRM
Mirum Pharmaceuticals
127.70
74.69
140.90%
AAPG
Ascentage Pharma Group International Unsponsored ADR
18.90
-21.84
-53.61%
Protagonist Therapeutics Corporate Events
Executive/Board ChangesShareholder Meetings
Protagonist Therapeutics Stockholders Approve Directors and Incentive Plan
Positive
Jun 18, 2026
At its recent Annual Meeting, Protagonist Therapeutics’ stockholders elected two Class I directors, Dinesh V. Patel and Lewis T. “Rusty” Williams, to serve until the 2029 Annual Meeting of Stockholders and until their successors ...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.