Clinical EfficacyThe prevention of neurodegeneration is suggested by a smaller increase in plasma NfL levels in treated patients compared to untreated patients.
Regulatory ProgressThe plan to seek FDA feedback on the design of the registrational study remains unchanged, and the recent agreement between Alector and the FDA on including plasma PGRN as a co-primary endpoint in the ongoing Ph3 study in FTD-GRN is seen as positive for PASG.
Safety ManagementPatient 9 was treated with no material safety events reported, indicating a possible improvement in safety management.