Clinical TrialsThe OPERA-01 trial is designed to showcase the efficacy of palazestrant in both ESR1-mutated and ESR1 wild-type populations, aiming for broad FDA approval.
Drug EfficacyPalazestrant is the only oral SERD that can safely achieve high exposures in combinations to accomplish complete ER saturation and inactivation.
PartnershipsOlema's recently disclosed clinical trial collaboration and supply agreement regarding Pfizer's aformociclib, in combination with their oral complete estrogen receptor (ER) antagonist (CERAN) and selective estrogen receptor degrader (SERD), palazestrant (OP-1250), suggests that Pfizer is still interested in the oral SERD space.