Market OpportunityGossamer Bio's seralutinib has a differentiated mechanism and favorable safety profile, which could be a key advantage in the large PAH market.
Novel Mechanism Of ActionSeralutinib's novel mechanism of action and improved safety from inhaled delivery are seen as strong points, with potential differentiation in the PAH market due to safety concerns with competitors.
Phase 2 ResultsThe open-label extension following the Phase 2 trial shows sustained hemodynamic and functional gains, including continued pulmonary vascular resistance reduction and incremental six-minute walk distance improvement among patients who remained on drug.