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Oncolys BioPharma, Inc. (JP:4588)
:4588
Japanese Market
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Oncolys BioPharma, Inc. (4588) AI Stock Analysis

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JP:4588

Oncolys BioPharma, Inc.

(4588)

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Neutral 50 (OpenAI - Gpt-5.6Sol)
Rating:50Neutral
Price Target:
¥4,810.00
▲(404.72% Upside)
Action:Reiterated
Date:08/29/26
The score is held down primarily by deteriorated fundamentals—sharp multi-year revenue decline, persistent large operating losses, and sustained cash burn suggesting continued financing risk. Technicals are a supporting positive due to strong upward trend and positive MACD, but elevated RSI/Stochastic indicates the move may be stretched. Valuation remains unattractive because profitability is negative and no dividend support is provided.
Positive Factors
Manageable Leverage
Relatively modest leverage reduces immediate balance-sheet pressure and gives Oncolys more flexibility to fund research, development and operating needs than a heavily indebted biotech.
Negative Factors
Severe Revenue Contraction
The multi-year collapse in revenue shows limited commercial scale and weak visibility into recurring income, leaving the company dependent on a major product, licensing or partnership-driven revenue inflection.
Read all positive and negative factors
Positive Factors
Negative Factors
Manageable Leverage
Relatively modest leverage reduces immediate balance-sheet pressure and gives Oncolys more flexibility to fund research, development and operating needs than a heavily indebted biotech.
Read all positive factors

Oncolys BioPharma, Inc. (4588) vs. iShares MSCI Japan ETF (EWJ)

Oncolys BioPharma, Inc. Business Overview & Revenue Model

Company Description
Oncolys BioPharma Inc. is a biotechnology firm dedicated to the research, development, manufacturing, sales, and distribution of oncolytic viruses, pharmaceutical drugs, and diagnostic agents for tumors across Japan, other Asian regions, and the U...
How the Company Makes Money
Detailed, company-specific revenue breakdown (e.g., product sales by drug, recurring service revenue, or disclosed milestone/royalty structures) is not available in the information provided here; therefore, this data point is null....

Oncolys BioPharma, Inc. Financial Statement Overview

Summary
Financials are weak overall: revenue collapsed from 976.2M (2022) to 63.0M (2023) and remains very low through 2025, while operating losses remain large (EBIT roughly -1.2B to -2.0B) and net income is deeply negative. Cash flow is a major concern with persistent, heavy operating cash outflows (~-1.3B to -2.0B) and negative free cash flow, implying ongoing external funding needs. The main offset is a comparatively manageable leverage position (debt-to-equity improved to ~0.12 in 2024) and an expanded equity base (~4.0B in 2025), providing some balance-sheet flexibility.
Income Statement
18
Very Negative
Balance Sheet
62
Positive
Cash Flow
21
Negative
BreakdownDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue28.55M31.38M63.04M976.18M642.49M
Gross Profit28.30M31.38M30.61M338.49M198.80M
EBITDA-2.05B-1.68B-1.93B-1.14B-1.60B
Net Income-2.06B-1.68B-1.94B-1.15B-1.62B
Balance Sheet
Total Assets4.56B3.20B2.04B2.65B4.29B
Cash, Cash Equivalents and Short-Term Investments3.72B2.41B1.53B1.71B3.45B
Total Debt320.02M324.64M315.17M393.66M503.47M
Total Liabilities555.91M446.65M566.50M491.69M697.88M
Stockholders Equity4.00B2.75B1.47B2.16B3.59B
Cash Flow
Free Cash Flow-1.94B-2.02B-1.34B-1.72B-1.74B
Operating Cash Flow-1.94B-2.02B-1.34B-1.72B-1.74B
Investing Cash Flow-7.58M-4.71M-5.39M20.12M-942.00K
Financing Cash Flow3.22B2.88B1.14B-113.83M3.09B

Oncolys BioPharma, Inc. Technical Analysis

Technical Analysis Sentiment
Positive
Last Price953.00
Price Trends
50DMA
2905.80
Positive
100DMA
2801.78
Positive
200DMA
2255.11
Positive
Market Momentum
MACD
423.37
Negative
RSI
79.47
Negative
STOCH
86.44
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JP:4588, the sentiment is Positive. The current price of 953 is below the 20-day moving average (MA) of 3357.25, below the 50-day MA of 2905.80, and below the 200-day MA of 2255.11, indicating a bullish trend. The MACD of 423.37 indicates Negative momentum. The RSI at 79.47 is Negative, neither overbought nor oversold. The STOCH value of 86.44 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for JP:4588.

Oncolys BioPharma, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (55)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
55
Neutral
$6.65B3.83-15.92%6.20%10.91%7.18%
50
Neutral
¥141.55B-87.521662.38%42.86%
50
Neutral
¥17.43B-13.31-8.52%
48
Neutral
¥144.69B-39.65-6.88%0.62%27.66%
45
Neutral
¥8.98B-9.32-51.98%-8.58%19.03%
40
Underperform
¥6.96B-6.48-19.99%16.36%
* General Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
JP:4588
Oncolys BioPharma, Inc.
4,810.00
4,157.00
636.60%
JP:4587
Peptidream
1,114.50
-415.50
-27.16%
JP:4564
OncoTherapy Science
22.00
-6.00
-21.43%
JP:4575
CanBas Co., Ltd.
884.00
-484.00
-35.38%
JP:4583
Chiome Bioscience Inc.
85.00
-53.00
-38.41%

Oncolys BioPharma, Inc. Corporate Events

Oncolys BioPharma Surges in Sales but Keeps Forecast and Dividends on Hold
Aug 7, 2026
Oncolys BioPharma reported a sharp jump in net sales to ¥503 million for the six months ended June 30, 2026, up more than 16-fold from a year earlier, while significantly narrowing its net loss to ¥762 million and improving basic loss pe...
Oncolys Wins Full Japanese Approval for First Oncolytic Virus in Esophageal Cancer
Jun 8, 2026
Oncolys BioPharma has secured full marketing approval in Japan for Telomelysin, an oncolytic adenovirus injection for esophageal cancer patients who are not candidates for curative surgery or chemoradiotherapy, marking the first approval of its ki...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 29, 2026