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Chiome Bioscience Inc. (4583) AI Stock Analysis

JP:4583

Chiome Bioscience Inc.

(TSE/TYO:4583)

Select Model
Rating:46Neutral
Price Target:JPY 102.00â–²(18.60% Upside)
Action:reiterated
Date:09/10/26

The overall score of 46 is heavily weighed down by the company's poor financial performance, including declining revenues, persistent unprofitability, and significant cash burn. A lack of traditional valuation support further suppresses the rating. However, the score is slightly lifted by moderately bullish short-to-medium-term technical momentum, as the stock trades above key moving averages despite its long-term downtrend.

Positive Factors
Modest LeverageModest leverage gives Chiome greater financial flexibility than a highly indebted biotechnology company. Lower debt obligations can reduce pressure on cash resources and preserve room for research investment, although this benefit depends on containing ongoing losses and cash use.
Negative Factors
Revenue Decline and VolatilityVolatile and declining revenue makes it harder for Chiome to build a dependable funding base for oncology research and development. The 2025 contraction after two years of growth suggests that commercial scale remains unproven and that future investment may rely on uncertain revenue recovery.

Chiome Bioscience Inc. (4583) vs. iShares MSCI Japan ETF (EWJ)

-60%-40%-20%0%20%40%JP:4583-34.35%EWJ+16.91%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
JPY 7.22B
Dividend Yield
―
Average Volume (3M)
1.56M
Price to Earnings (P/E)
-6.6
Beta (1Y)
0.58
Revenue Growth
-19.99%
EPS Growth
16.36%
Country
Japan
Employees
49
Sector
General
Sector Strength
55
Industry
Biotechnology

Chiome Bioscience Inc. Business Overview & Revenue Model

Company Description

Chiome Bioscience Inc. engages in the research and development of drug discovery technology platforms worldwide. It operates in two segments, Drug Discovery Business and Drug Discovery Support Business. The company offers ADLib System, a technology f...

How the Company Makes Money

Publicly available, company-specific details on Chiome Bioscience Inc.’s current revenue model and the breakdown of its revenue streams (e.g., product sales vs. licensing, collaboration milestones, research funding, or royalties), as well as signific...

Chiome Bioscience Inc. Financial Statement Overview

Summary

The company faces significant fundamental risks. Despite a conservative debt-to-equity ratio of 0.23, severe unprofitability, a 23% revenue contraction, and critical cash burn levels threaten long-term operational sustainability.

Income Statement

25Negative

Balance Sheet

42Neutral

Cash Flow

20Very Negative
Financial statement breakdown
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue615.15M593.29M780.81M682.46M630.82M480.85M
Gross Profit375.24M355.58M432.02M397.72M347.78M242.81M
EBITDA-910.50M-972.64M-1.01B-1.21B-1.24B-1.28B
Net Income-925.73M-982.78M-1.02B-1.22B-1.24B-1.29B
Balance Sheet
Total Assets1.91B1.73B2.47B1.75B2.22B3.49B
Cash, Cash Equivalents and Short-Term Investments1.37B1.21B2.06B1.33B1.73B2.69B
Total Debt67.50M261.70M281.50M291.00M184.00M180.00M
Total Liabilities341.26M605.44M548.55M593.73M424.72M384.58M
Stockholders Equity1.57B1.12B1.92B1.16B1.79B3.11B
Cash Flow
Free Cash Flow0-976.07M-1.00B0-1.19B0
Operating Cash Flow0-935.99M-1.00B-1.07B-1.19B-1.36B
Investing Cash Flow0-55.46M0173.00K0-3.52M
Financing Cash Flow0133.20M1.74B667.30M1.13B1.94B

Chiome Bioscience Inc. Technical Analysis

Technical Analysis SentimentNegative
Last Price86.00

Price Trends

50DMA92.56Negative
100DMA82.15Positive
200DMA93.37Negative

Market Momentum

MACD-0.84Positive
RSI43.59Neutral
STOCH36.67Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JP:4583, the sentiment is Negative. The current price of 86.00 is below the 20-day moving average (MA) of 93.40, below the 50-day MA of 92.56, and below the 200-day MA of 93.37, indicating a bearish trend. The MACD of -0.84 indicates Positive momentum. The RSI at 43.59 is Neutral, neither overbought nor oversold. The STOCH value of 36.67 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JP:4583.

Chiome Bioscience Inc. Peers Comparison

Overall Rating

UnderperformOutperform
Sector (55)

Financial Indicators

JP:4583 against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
JP:4570JP:457078OutperformJPY 9.56B25.52―0.59%13.46%42.41%
JP:4565JP:456563NeutralJPY 133.37B-26.50-8.51%―23.72%12.48%
JP:4579JP:457960NeutralJPY 16.61B69.05――20.64%―
Sector *55Neutral$6.65B3.83-15.92%6.20%10.91%7.18%
JP:4588JP:458855NeutralJPY 223.32B-143.92――1662.38%42.86%
JP:4583JP:458346NeutralJPY 7.29B-6.56――-19.99%16.36%
JP:4587JP:458742NeutralJPY 145.02B-39.81-7.17%―0.62%27.66%

* General Sector Average

Performance Comparison

0%200%400%600%800%JP:4583JP:4587JP:4565JP:4570JP:4579JP:4588Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
JP:4583 and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
JP:4583Chiome Bioscience Inc.86.00-42.00-32.81%
JP:4587Peptidream 1119.00-412.00-26.91%
JP:4565Sosei Group Corporation1585.00782.0097.38%
JP:4570Immuno-Biological Laboratories Co., Ltd.1009.00538.02114.23%
JP:4579RaQualia Pharma Inc.618.0090.0017.05%
JP:4588Oncolys BioPharma, Inc.7910.007145.00933.99%

Chiome Bioscience Inc. Corporate Events

Chiome Bioscience Outlines Q2 FY2026 Results and R&D Focus

Aug 13, 2026

Chiome Bioscience has released supplementary information for its second-quarter fiscal 2026 results, outlining financial performance and operational highlights for the period. The materials also reference updates to the company’s therapeutic an...

Chiome Bioscience Narrows Losses as Sales Rise and Balance Sheet Strengthens

Aug 13, 2026

Chiome Bioscience reported non-consolidated net sales of ¥273 million for the six months ended June 30, 2026, an 8.7% increase year on year, while narrowing its net loss to ¥483 million as operating and ordinary losses also improved. Total...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Sep 10, 2026