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Chiome Bioscience Inc. (4583) AI Stock Analysis

2 Followers
JP:4583

Chiome Bioscience Inc.

(TSE/TYO:4583)

Select Model
Rating:46Neutral
Price Target:JPY 75.00â–¼(-2.60% Downside)
Action:reiterated
Date:09/10/26

The overall score of 46 is heavily weighed down by the company's poor financial performance, including declining revenues, persistent unprofitability, and significant cash burn. A lack of traditional valuation support further suppresses the rating. However, the score is slightly lifted by moderately bullish short-to-medium-term technical momentum, as the stock trades above key moving averages despite its long-term downtrend.

Positive Factors
Low LeverageModest leverage gives Chiome greater financial flexibility than a highly indebted biotech company and reduces the immediate burden of interest and refinancing. This balance-sheet support may help preserve strategic options while the company works to improve its development economics.
Negative Factors
Revenue Volatility and DeclineVolatile revenue and the sharp 2025 decline make it difficult to establish a dependable growth trajectory for Chiome’s drug discovery business. Unstable top-line performance can constrain investment planning and delay the operating scale needed to absorb research and development costs.

Chiome Bioscience Inc. (4583) vs. iShares MSCI Japan ETF (EWJ)

-50%-40%-30%-20%-10%0%10%20%30%JP:4583-37.40%EWJ+16.06%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
JPY 6.25B
Dividend Yield
―
Average Volume (3M)
1.62M
Price to Earnings (P/E)
-6.2
Beta (1Y)
0.73
Revenue Growth
-13.40%
EPS Growth
7.50%
Country
Japan
Employees
49
Sector
General
Sector Strength
55
Industry
Biotechnology

Chiome Bioscience Inc. Business Overview & Revenue Model

Company Description

Chiome Bioscience Inc. engages in the research and development of drug discovery technology platforms worldwide. It operates in two segments, Drug Discovery Business and Drug Discovery Support Business. The company offers ADLib System, a technology f...

How the Company Makes Money

Publicly available, company-specific details on Chiome Bioscience Inc.’s current revenue model and the breakdown of its revenue streams (e.g., product sales vs. licensing, collaboration milestones, research funding, or royalties), as well as signific...

Chiome Bioscience Inc. Financial Statement Overview

Summary

The company faces significant fundamental risks. Despite a conservative debt-to-equity ratio of 0.23, severe unprofitability, a 23% revenue contraction, and critical cash burn levels threaten long-term operational sustainability.

Income Statement

25Negative

Balance Sheet

42Neutral

Cash Flow

20Very Negative
Financial statement breakdown
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue615.15M593.29M780.81M682.46M630.82M480.85M
Gross Profit375.24M355.58M432.02M397.72M347.78M242.81M
EBITDA-910.50M-972.64M-1.01B-1.21B-1.24B-1.28B
Net Income-925.73M-982.78M-1.02B-1.22B-1.24B-1.29B
Balance Sheet
Total Assets1.91B1.73B2.47B1.75B2.22B3.49B
Cash, Cash Equivalents and Short-Term Investments1.37B1.21B2.06B1.33B1.73B2.69B
Total Debt67.50M261.70M281.50M291.00M184.00M180.00M
Total Liabilities341.26M605.44M548.55M593.73M424.72M384.58M
Stockholders Equity1.57B1.12B1.92B1.16B1.79B3.11B
Cash Flow
Free Cash Flow0-976.07M-1.00B0-1.19B0
Operating Cash Flow0-935.99M-1.00B-1.07B-1.19B-1.36B
Investing Cash Flow0-55.46M0173.00K0-3.52M
Financing Cash Flow0133.20M1.74B667.30M1.13B1.94B

Chiome Bioscience Inc. Technical Analysis

Technical Analysis SentimentNegative
Last Price77.00

Price Trends

50DMA91.74Negative
100DMA83.02Negative
200DMA91.78Negative

Market Momentum

MACD-4.38Positive
RSI37.09Neutral
STOCH24.70Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JP:4583, the sentiment is Negative. The current price of 77.00 is below the 20-day moving average (MA) of 86.00, below the 50-day MA of 91.74, and below the 200-day MA of 91.78, indicating a bearish trend. The MACD of -4.38 indicates Positive momentum. The RSI at 37.09 is Neutral, neither overbought nor oversold. The STOCH value of 24.70 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JP:4583.

Chiome Bioscience Inc. Peers Comparison

Overall Rating

UnderperformOutperform
Sector (55)

Financial Indicators

JP:4583 against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
JP:4570JP:457077OutperformJPY 8.54B22.84―0.65%7.10%17.17%
JP:4565JP:456566NeutralJPY 167.91B-30.31-8.51%―23.72%12.48%
Sector *55Neutral$6.65B3.83-15.92%6.20%10.91%7.18%
JP:4588JP:458855NeutralJPY 248.42B-152.49――1748.97%35.11%
JP:4587JP:458748NeutralJPY 138.26B-47.42-5.85%―14.25%50.07%
JP:4583JP:458346NeutralJPY 6.30B-6.19――-13.40%7.50%
JP:4579JP:457943NeutralJPY 16.82B72.18――31.84%―

* General Sector Average

Performance Comparison

0%200%400%600%JP:4583JP:4587JP:4565JP:4570JP:4579JP:4588Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
JP:4583 and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
JP:4583Chiome Bioscience Inc.77.00-46.00-37.40%
JP:4587Peptidream 1065.00-518.50-32.74%
JP:4565Sosei Group Corporation1813.00954.00111.06%
JP:4570Immuno-Biological Laboratories Co., Ltd.917.0069.638.22%
JP:4579RaQualia Pharma Inc.646.00105.0019.41%
JP:4588Oncolys BioPharma, Inc.8410.007342.00687.45%

Chiome Bioscience Inc. Corporate Events

Chiome Bioscience Provides Supplementary Information on Q3 FY12/26 Financial Results

Nov 10, 2026

Chiome Bioscience Inc. is presented as focused on accelerating monoclonal antibody (mAb) drug discovery and development for therapeutics addressing current medical unmet needs.The Nov. 10, 2026 supplementary information is organized around Q3 FY12/26...

Chiome Reports Nine-Month Sales of ¥406 Million, Narrower Losses

Nov 10, 2026

Chiome Bioscience Inc. is a bioscience company engaged in Drug Discovery and Development and Drug Discovery Support businesses. Its shares are listed on the Tokyo Stock Exchange under code 4583, and the release reports non-consolidated results under...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Sep 10, 2026