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Compugen (CGEN) AI Stock Analysis

IL:CGEN

Compugen

(TASE:CGEN)

Rating:―N/A
Action:N/A
Date:―

No summary available

Positive Factors
Proprietary discovery platformThe Unigen platform has already generated multiple immuno-oncology targets grounded in human disease biology, providing Compugen with a repeatable source of potential candidates. This platform capability can support future pipeline replenishment and strengthen the company’s strategic value to larger pharmaceutical partners over time.
Negative Factors
Lumpy revenue and ongoing lossesThe company remains dependent on modest collaboration-related revenue while continuing to report quarterly net losses, and recent revenue growth partly reflects milestone recognition. This makes earnings power less predictable and leaves sustained operations reliant on cash reserves and future partnership receipts.

Compugen (CGEN) vs. iShares MSCI Israel ETF (EIS)

-20%0%20%40%60%80%IL:CGEN+11.97%EIS+13.14%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
Market Cap
ILS 187.55M
Dividend Yield
―
Average Volume (3M)
32.53K
Price to Earnings (P/E)
5.1
Beta (1Y)
1.01
Revenue Growth
193.15%
EPS Growth
―
Country
Israel
Employees
75
Sector
General
Sector Strength
55
Industry
Biotechnology

Compugen Business Overview & Revenue Model

Company Description

Compugen Ltd., an Israeli-based company established in 1993 and headquartered in Holon, is a clinical-stage enterprise focused on the discovery, development, and commercialization of therapeutic and product candidates. Its operations extend across Is...

Compugen Earnings Call Summary

Earnings Call Date:Aug 02, 2026(Q2-2026)|% Change Since:-11.94%|Next Earnings Date:Nov 08, 2026
Earnings Call SentimentPositive

The call conveyed measurable progress across Compugen's pipeline and partnerships — notable trial milestones (MAIA interim due Q1 2027), encouraging partner data (rilvegostomig ASCO OS signal), strengthened cash runway into 2029, and material milestone/royalty upside from Gilead and AstraZeneca. Offsetting these positives are key uncertainties: MAIA's exploratory design and lowered control-arm PFS benchmark, absence of pre-readout FDA engagement, early-stage status and limited visibility for GS-0321 data, dependency on partner execution for value realization, and continued modest absolute revenues with ongoing net losses. Overall, the fundamentals improved and near-term clinical and financial visibility increased, but meaningful regulatory and partner-driven milestones remain future-dependent.

Positive Updates

MAIA-ovarian Progress and Upcoming Interim Analysis
MAIA-ovarian (COM701 monotherapy) continuing on track for interim analysis by Q1 2027; trial is randomized with ~40 patients on COM701 vs ~20 placebo, and clinically meaningful success defined as PFS ≥ 6 months.

Negative Updates

MAIA Control Arm Benchmark Revised Downward
Based on two recent European trials (TEDOVA and OReO) the company revised its estimate for the MAIA placebo control median PFS to ~4 months versus historical PARP registration benchmarks (~5.5 months) — a reduction of ~1.5 months (~27% decrease) — introducing uncertainty around baseline assumptions.

Company Guidance

Management guided that the MAIA‑ovarian interim analysis (median PFS data) is expected by Q1 2027, estimating the blinded placebo control median PFS at ~4 months (citing recent European trial control arms at 2.8 months and historical PARP registration ~5.5 months) and defining clinically meaningful success as ≥6 months PFS; MAIA is an exploratory, placebo‑controlled randomized trial (COM701 monotherapy ~40 patients vs ~20 placebo) and is not powered as a registrational study. On the financial side, cash and equivalents were ~$125.3M as of June 30, 2026 with a cash runway into 2029 assuming no further inflows; Q2‑2026 revenue was ~$2.6M (vs ~$1.3M a year ago), R&D expense ~$6.3M (vs ~$5.6M), G&A ~$2.3M (vs ~$2.2M), and net loss ~ $7.0M or $0.07 per share (vs ~$7.3M or $0.08). Partnership and pipeline metrics highlighted include $90M received to date from Gilead for GS‑0321 (up to $758M additional milestones + single‑digit to low‑double‑digit royalties), AstraZeneca adding a 12th Phase III rilvegostomig trial and previously guiding a >$5B non‑risk‑adjusted peak‑year revenue potential (plus up to $195M in milestones and mid‑single‑digit tiered royalties), and AstraZeneca’s GEMINI hepatobiliary rilve combo showing 16.8 months OS versus historical <13 months.

Compugen Risk Analysis

Compugen disclosed 79 risk factors in its most recent earnings report. Compugen reported the most risks in the "Tech & Innovation" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Tech & Innovation - Risks related to the company’s reliance on technology and ability to make innovative products

Latest Risks Added

2 New Risks
1.Environmental, social and governance matters may impact our business and reputation.Q4, 2021
2.The dollar cost of our operations in Israel will increase to the extent increases in the rate of inflation in Israel are not offset by a devaluation of the NIS in relation to the dollar, which would harm our results of operations.Q4, 2021

Compugen Peers Comparison

Overall Rating

UnderperformOutperform
Sector (55)

Financial Indicators

IL:CGEN against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
NVCTNVCT56Neutral$603.26M-14.11-169.47%――-13.52%
Sector *55Neutral$6.65B3.83-15.92%6.20%10.91%7.18%
STTKSTTK45Neutral$558.02M-10.90-43.57%―-66.63%57.89%
NKTXNKTX42Neutral$111.73M-0.99-39.64%――-6.70%
CCCCCCCC41Neutral$414.59M-3.37-45.45%―2.33%36.86%
ELTXELTX40Underperform$45.51M-0.79-1266.43%――49.43%

* General Sector Average

Performance Comparison

0%100%200%300%IL:CGENNKTXCCCCSTTKELTXNVCTDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
IL:CGEN and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
IL:CGENCompugen623.2063.1011.27%
NKTXNkarta, Inc.1.56-0.51-24.64%
CCCCC4 Therapeutics, Inc.3.370.8935.89%
STTKShattuck Labs, Inc.5.563.57179.40%
ELTXElicio Therapeutics, Inc1.68-7.57-81.84%
NVCTNuvectis Pharma, Inc.18.4812.12190.57%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.