Drug Safety ConcernsFor APLS' Syfovre, there were 73 additional serious adverse events reported, including 10 additional cases of retinal vasculitis and 2 deaths.
Market CompetitionSurvey results suggest a loss of Syfovre's market share leadership within just one year, highlighting competitive pressures.
Regulatory ChallengesApellis Pharmaceuticals is facing a re-review of pegcetacoplan for GA due to potential conflicts of interest in the original expert group, which could negatively impact approval prospects.