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CareDx (CDNA) AI Stock Analysis

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CDNA

CareDx

(NASDAQ:CDNA)

Select Model
Rating:74Outperform
Price Target:$88.00â–²(12.99% Upside)
Action:reiterated
Date:10/31/26

CDNA scores well on a strong financial rebound and conservative balance sheet, reinforced by a very positive earnings call with raised revenue and EBITDA guidance. The score is moderated by an extended/overbought technical setup and a less compelling valuation (P/E ~35) with no dividend yield provided, which increases sensitivity to execution and any growth/margin disappointments.

Positive Factors
Broad Revenue and Testing GrowthThe raised outlook and strong testing-volume trajectory indicate expanding adoption across transplant diagnostics and specialty oncology. Growth supported by higher utilization, broader clinical workflows, and new offerings can strengthen CareDx’s revenue base and operating scale over the next several quarters.
Negative Factors
Gross Margin PressureThe substantial gross-margin decline suggests that pricing, product mix, or service costs are reducing the profitability of each dollar of revenue. Even with rapid growth, sustained margin pressure could limit operating leverage and make future earnings more dependent on continued volume expansion.

CareDx Key Performance Indicators (KPIs)

Revenue by SegmentShows how the company’s sales break down across its different business lines (for example diagnostics, lab services, and recurring testing or monitoring). That split reveals which parts of the business are driving growth, which produce steadier, subscription-like income, and which are more exposed to reimbursement changes, competition, or single-customer concentration—key for judging future revenue stability and upside potential.

$0.00$25.00M$50.00M$75.00M$100.00M$125.00MMar 21Jun 21Sep 21Dec 21Mar 22Jun 22Sep 22Dec 22Mar 23Jun 23Sep 23Dec 23Mar 24Jun 24Sep 24Dec 24Mar 25Jun 25Sep 25Dec 25Mar 26Jun 26Sep 26
Chart Insights

Testing Services recovered strongly since mid‑2024, suggesting restored lab volumes and contract wins that reestablish it as the revenue backbone; Products have grown steadily with periodic seasoning and recent cadence indicating stronger sell‑through, while Patient & Digital Solutions is the fastest-growing piece, scaling rapidly and shifting the mix toward higher-margin recurring software/services. Together the trend points to improved revenue diversification and lower sensitivity to past testing-volume troughs.

Data provided by:The Fly

CareDx (CDNA) vs. SPDR S&P 500 ETF (SPY)

-100%0%100%200%300%400%500%CDNA+394.16%SPY+14.55%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
$4.19B
Dividend Yield
―
Average Volume (3M)
1.32M
Price to Earnings (P/E)
31.3
Beta (1Y)
0.93
Revenue Growth
38.94%
EPS Growth
91.53%
Country
US
Employees
763
Sector
Healthcare
Sector Strength
51
Industry
Medical - Diagnostics & Research

CareDx Business Overview & Revenue Model

Company Description

CareDx, Inc. is a global innovator specializing in the discovery, development, and commercialization of diagnostic and management tools designed for transplant recipients and their healthcare providers. The company's extensive portfolio features a ra...

How the Company Makes Money

CareDx primarily makes money by providing transplant-related diagnostic testing and associated services to transplant centers and clinicians, with revenue recognized when tests and services are performed/delivered. A key revenue stream is its clinica...

CareDx Earnings Call Summary

Earnings Call Date:Oct 29, 2026(Q3-2026)|% Change Since:8.89%|Next Earnings Date:Mar 03, 2027
Earnings Call SentimentPositive

The call was strongly positive, characterized by broad-based revenue and testing-volume growth, higher margins and EBITDA, increased full-year guidance, a strong cash position, continued transplant adoption, progress integrating NavDx and advancing AlloHeme and HistoMap. The main limitations were the contribution from out-of-period revenue, the early nature of some NavDx evidence, the later expected timing of AlloHeme coverage and revenue, and the relatively small stated HistoMap market.

Positive Updates

Strong Third-Quarter Financial Performance
Third-quarter revenue was $139 million, up 39% year over year and 6% sequentially. Testing volume reached 75,900 tests, up 51% year over year and 31% sequentially. Non-GAAP gross margin was 74%, compared with 71% in the prior-year quarter, and adjusted EBITDA was $30 million, or 22% of revenue, doubling from $15 million.

Negative Updates

Out-of-Period Revenue Contribution
Third-quarter revenue included $15 million of out-of-period revenue, up from $6 million in the prior-year quarter. Excluding out-of-period revenue, total revenue growth was 32% year over year instead of the reported 39%, and testing-services growth was 58% instead of 65%.

Company Guidance

CareDx increased 2026 full year revenue guidance by $30 million to $520 million to $530 million, or $525 million, with 38% year-over-year growth at the midpoint of the range, and full year adjusted EBITDA guidance by $23 million to $90 million to $100 million, or $95 million at the midpoint of the range and 18% of revenue; Q4 2026 assumptions include total revenue of $131 million to $141 million, or 25% year-over-year growth at the $136 million midpoint of the range, testing services revenue of $112 million to $122 million, or 50% year-over-year growth at the $117 million midpoint of the range, 76,000 to 80,000 tests, or 47% year-over-year growth at the 78,000 midpoint of the range, transplant volume of 61,000 to 63,000 tests, or 17% year-over-year growth at the 62,000 test midpoint of the range, 15,000 to 17,000 specialty oncology tests, approximately $1,500 revenue per test, 71% to 72% non-GAAP gross margins, non-GAAP operating expenses of approximately $79 million, plus or minus $2 million, and adjusted EBITDA of $16 million to $26 million, or $21 million at the midpoint of the range, representing approximately 15% of revenue; the company expects AlloHeme commercial launch in the first quarter of 2027, HistoMap broader commercial availability in 2027, solid organ transplant growth of 15% year-over-year in 2027, NavDx growth of 30% to 40% for the next 2 years, through 2027, and previously anticipated coverage for AlloHeme likely in '28 with significant revenues in 2029.

CareDx Financial Statement Overview

Summary

Financials reflect a clear rebound: TTM profitability turned meaningfully positive with strong net margin, and operating cash flow/free cash flow are solidly positive. The balance sheet is a major strength with very low leverage and improved equity. Offsets include a material step-down in gross margin versus prior years, near-breakeven operating income (suggesting profitability is not yet fully operating-driven), and softer/variable cash flow dynamics versus net income.

Income Statement

64Positive

Balance Sheet

82Very Positive

Cash Flow

67Positive
Financial statement breakdown
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue497.40M379.81M333.79M280.32M321.79M296.40M
Gross Profit353.00M256.57M224.16M178.32M209.58M199.01M
EBITDA28.54M-4.66M-33.99M-84.92M-60.23M-20.20M
Net Income128.63M-21.35M52.55M-190.28M-76.61M-30.66M
Balance Sheet
Total Assets641.46M413.23M491.05M466.83M542.99M566.62M
Cash, Cash Equivalents and Short-Term Investments250.48M177.21M260.65M235.42M293.09M348.49M
Total Debt29.00M26.19M28.37M34.22M39.00M21.35M
Total Liabilities174.00M110.13M112.62M205.50M112.08M100.75M
Stockholders Equity467.46M303.10M378.43M261.33M430.91M465.88M
Cash Flow
Free Cash Flow60.10M36.12M31.56M-27.63M-49.57M-39.55M
Operating Cash Flow69.02M42.03M38.05M-18.39M-25.24M-19.29M
Investing Cash Flow108.85M2.16M-483.00K40.45M-228.50M47.71M
Financing Cash Flow-17.97M-93.39M-5.61M-29.61M-4.54M185.64M

CareDx Technical Analysis

Technical Analysis SentimentPositive
Last Price77.88

Price Trends

50DMA66.34Positive
100DMA53.30Positive
200DMA36.71Positive

Market Momentum

MACD4.39Positive
RSI54.75Neutral
STOCH26.07Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CDNA, the sentiment is Positive. The current price of 77.88 is above the 20-day moving average (MA) of 76.76, above the 50-day MA of 66.34, and above the 200-day MA of 36.71, indicating a bullish trend. The MACD of 4.39 indicates Positive momentum. The RSI at 54.75 is Neutral, neither overbought nor oversold. The STOCH value of 26.07 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for CDNA.

CareDx Risk Analysis

CareDx disclosed 64 risk factors in its most recent earnings report. CareDx reported the most risks in the "Finance & Corporate" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy

Latest Risks Added

3 New Risks
1.If we fail to maintain an effective system of internal controls, our ability to produce timely and accurate financial statements or comply with applicable regulations could be impaired.Q4, 2025
2.Changes in U.S. patent law or the patent law of other countries or jurisdictions could diminish the value of patents in general, thereby impairing our ability to protect our products.Q4, 2025
3.Obtaining and maintaining our patent protection depends on compliance with various procedural, document submission, fee payment and other requirements imposed by governmental patent agencies, and our patent protection could be reduced or eliminated for noncompliance with these requirements.Q4, 2025

CareDx Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

CDNA against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
DGXDGX76Outperform$28.57B25.5015.21%1.30%9.13%17.93%
LHLH75Outperform$30.23B30.1911.54%0.78%6.02%19.63%
CDNACDNA74Outperform$4.19B31.2834.08%―38.94%91.53%
VCYTVCYT70Outperform$1.99B15.309.27%―17.50%311.25%
NTRANTRA63Neutral$46.83B-279.90-9.18%―37.43%49.82%
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
GHGH44Neutral$20.95B-41.22249.03%―41.69%-14.59%

* Healthcare Sector Average

Performance Comparison

0%200%400%CDNALHDGXVCYTNTRAGHDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
CDNA and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
CDNACareDx Inc77.8862.37402.13%
LHLabcorp Holdings Inc.370.48111.7343.18%
DGXQuest Diagnostics259.6076.4941.77%
VCYTVeracyte Inc24.33-14.95-38.06%
NTRANatera Inc.319.09113.0554.87%
GHGuardant Health151.7055.2257.23%

CareDx Corporate Events

Business Operations and StrategyFinancial DisclosuresM&A Transactions

CareDx lifts 2026 outlook after strong Q3 results

Positive
Oct 29, 2026

CareDx reported strong third-quarter 2026 results, with revenue rising 39% year over year to $139 million and testing services revenue jumping 65% to $119 million, supported by higher volumes and the addition of specialty oncology through NavDx. GAAP...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Oct 31, 2026