Strong Vafseo Quarterly Revenue Growth
Vafseo net product revenues were $15.8M in Q1 2026 versus $12.0M in Q1 2025, a 32% year-over-year increase and the highest quarter of Vafseo revenue to date.
Rapid Patient and Prescriber Adoption
Patients on Vafseo increased nearly 60% quarter-over-quarter to ~7,500 at the end of Q1 2026 (vs end of Q4 2025). Approximately 1,025 prescribers wrote scripts in Q1, ~28% higher than Q4 2025, and ~30% of prescribers were from dialysis organizations other than USRC.
Improved Adherence with Observed Dosing
Approximately two-thirds of Vafseo patients were treated 3x weekly by quarter end. First-refill adherence for patients under observed dosing protocols was ~86%, consistent with historical 85–90% levels and expected to remain stable as adoption scales.
Favorable Real-World and Clinical Evidence
Post-hoc INNOVATE analysis published in JASN showed lower risk of death or hospitalization for Vafseo vs ESA. Economic analysis indicated 7.7% fewer hospitalization events, a 16% reduction in hospitalization days, and a 14.8% lower annual hospitalization cost (Medicare-based) for Vadadustat-treated patients.
Ongoing and Upcoming Clinical Milestones
VOCAL topline results (DaVita clinics, 3x weekly dosing) expected by year-end 2026; VOICE topline expected early 2027. Multiple pipeline programs advancing: praliciguat Phase II (FSGS, up to ~60 patients), AKB-097 (Abribafisp) Phase II basket trial planned H2 2026, and AKB-9090 Phase I initiated with topline expected early 2027.
Commercial Momentum Beyond Initial Provider
Adoption is broadening across dialysis organizations: USRC, IRC and DCI progressed to observed dosing with rapid uptake; DaVita showing growth and expected to move to observed dosing in H2 2026, representing a large addressable opportunity.
Strategic R&D Positioning and Investor Engagement
R&D Day in April showcased preclinical and clinical data (praliciguat, AKB-097) with positive reception from clinical experts; company emphasizes kidney-disease focused pipeline as a multi-product, long-term value driver.
Sufficient Near-Term Liquidity
Cash and cash equivalents were $162.6M as of March 31, 2026. Company expects existing cash resources and cash from operations to fund the current operating plan for at least two years.