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Zevra Therapeutics (ZVRA)
NASDAQ:ZVRA
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Zevra Therapeutics (ZVRA) AI Stock Analysis

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ZVRA

Zevra Therapeutics

(NASDAQ:ZVRA)

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Neutral 61 (OpenAI - 4o)
Rating:61Neutral
Price Target:
$9.50
▲(7.83% Upside)
Zevra Therapeutics' overall score is driven by strong earnings call performance and reasonable valuation. However, financial performance issues, particularly in profitability and cash flow, along with bearish technical indicators, weigh down the score.
Positive Factors
Revenue Growth
Sustained revenue growth indicates successful product adoption and market penetration, supporting long-term financial health and expansion.
European Market Expansion
Expanding into the European market could significantly increase Zevra's patient base and revenue potential, enhancing its global footprint.
Robust Financial Position
A strong cash position provides Zevra with the financial flexibility to invest in strategic priorities and withstand industry challenges.
Negative Factors
Profitability Challenges
Persistent profitability issues can hinder reinvestment in R&D and limit competitive positioning, affecting long-term growth potential.
Negative Cash Flows
Negative cash flows can strain liquidity and operational flexibility, potentially impacting the company's ability to fund future growth initiatives.
Slow Trial Enrollment
Slow trial enrollment can delay product development timelines, affecting future revenue streams and competitive advantage in the market.

Zevra Therapeutics (ZVRA) vs. SPDR S&P 500 ETF (SPY)

Zevra Therapeutics Business Overview & Revenue Model

Company DescriptionZevra Therapeutics, Inc., a rare disease company melding science, discovers and develops various proprietary prodrugs to treat serious medical conditions in the United States. The company utilizes its Ligand Activated Therapy technology to generate improved prodrug versions of FDA-approved drugs, as well as to generate prodrug versions of existing compounds that may have applications for new disease indications. Its prodrug product candidate pipeline is focused on the high need areas of attention deficit hyperactivity disorder, stimulant use disorder, and CNS rare diseases, including idiopathic hypersomnia (IH). The company's lead product candidate KP1077, which is under Phase II clinical trial for the treatment of IH and narcolepsy, is based on its prodrug of d-methylphenidate, known as serdexmethylphenidate. It is also developing KP879, a prodrug product candidate for the treatment of stimulant use disorder and is under Phase II clinical trial. In addition, the company has received FDA approval for AZSTARYS, a once-daily treatment for attention deficit hyperactivity disorder in patents age six years and older, and for APADAZ, an immediate-release combination product containing benzhydrocodone, a prodrug of hydrocodone, and acetaminophen. The company's product pipeline include, arimoclomol It has collaboration and license agreement with KVK-Tech, Inc. and Commave Therapeutics SA. The company was formerly known as KemPharm, Inc. and changed its name to Zevra Therapeutics, Inc. in February 2023. Zevra Therapeutics, Inc. was incorporated in 2006 and is headquartered in Celebration, Florida.
How the Company Makes MoneyZevra Therapeutics generates revenue primarily through the commercialization of its pharmaceutical products, which involves selling approved therapies to healthcare providers and patients. The company may also engage in licensing agreements and partnerships with larger pharmaceutical companies for the co-development and distribution of its drugs, providing additional revenue streams through upfront payments, milestone payments, and royalties on future sales. Additionally, funding from government grants and research institutions to support clinical trials can contribute to its earnings. As Zevra advances its drug candidates through clinical trials and regulatory approvals, successful product launches and market penetration are critical for driving its financial performance.

Zevra Therapeutics Earnings Call Summary

Earnings Call Date:Nov 05, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 11, 2026
Earnings Call Sentiment Positive
The earnings call highlighted the strong performance and strategic advancements of MIPLYFFA, particularly its revenue contribution and expansion into the European market. However, the company faces challenges with OLPRUVA and slow enrollment in the DiSCOVER trial. Despite these challenges, the financial position remains robust, supporting future strategic goals.
Q3-2025 Updates
Positive Updates
Strong Performance of MIPLYFFA
Third quarter net revenue reached $26.1 million, driven by $22.4 million from MIPLYFFA. Additionally, there were 8 new prescription enrollment forms received in the quarter, bringing the total to 137 since MIPLYFFA became commercially available a year ago.
European Market Expansion
A Marketing Authorization Application (MAA) has been filed with the European Medicines Agency for MIPLYFFA, and the application has been validated and is under review. The potential of expanding into the European market could significantly increase the patient base.
Patent and Market Access Progress
Zevra has established a solid patent position for MIPLYFFA and requested a patent term extension with the U.S. Patent and Trademark Office. Covered lives for MIPLYFFA increased to 66% in the third quarter, reflecting strong market access development.
Robust Financial Position
As of September 30, 2025, total cash, cash equivalents, and investments were $230.4 million, an increase of $12.7 million compared to the end of Q2 2025. The company believes available financial resources are sufficient to execute on strategic priorities.
Negative Updates
Challenges with OLPRUVA
Despite efforts, OLPRUVA’s clinical differentiation has not penetrated a mature and well-served UCD market. The company decided to scale back sales and marketing efforts for OLPRUVA.
Slow Enrollment in DiSCOVER Trial
In the third quarter, only 5 additional patients were enrolled in the DiSCOVER trial for Celiprolol, bringing the total to 44 out of 150 required for full enrollment, indicating a slow recruitment process.
Company Guidance
During Zevra's Third Quarter 2025 Financial Results and Corporate Update Conference Call, the company reported significant metrics indicating strong performance and strategic growth. Zevra's net revenue for the quarter was $26.1 million, with $22.4 million attributed to MIPLYFFA, a treatment for Niemann-Pick disease type C (NPC). The call highlighted that since MIPLYFFA became commercially available, a total of 137 prescription enrollment forms had been received, including 8 new forms in the third quarter. The company also emphasized its expansion efforts into the European market, where an estimated 1,100 people live with NPC. The Marketing Authorization Application for MIPLYFFA was filed in July and is under review by the European Medicines Agency. Additionally, Zevra's development pipeline was discussed, notably the DiSCOVER trial for Celiprolol as a treatment for Vascular Ehlers-Danlos Syndrome, with 44 out of 150 patients enrolled. Financially, Zevra ended the quarter with $230.4 million in cash, cash equivalents, and investments, reflecting a strong balance sheet to support its strategic priorities.

Zevra Therapeutics Financial Statement Overview

Summary
Zevra Therapeutics shows strong revenue growth, but profitability and cash flow challenges persist. The balance sheet reflects improved leverage, yet low returns on equity and negative cash flows hinder overall financial health.
Income Statement
65
Positive
Zevra Therapeutics shows a strong revenue growth rate of 36.07% in the TTM, indicating positive momentum. However, the company struggles with profitability, as evidenced by negative EBIT and EBITDA margins. The net profit margin has improved to 4.26% in the TTM, a significant recovery from previous negative margins, suggesting better cost management or revenue mix.
Balance Sheet
55
Neutral
The company's debt-to-equity ratio has improved to 0.53 in the TTM, reflecting a more balanced capital structure compared to previous years. However, the return on equity remains low at 3.95%, indicating limited profitability relative to shareholder equity. The equity ratio is stable, suggesting a solid asset base.
Cash Flow
50
Neutral
Zevra Therapeutics faces challenges with negative operating and free cash flows, which have deteriorated further in the TTM. The free cash flow to net income ratio is slightly above 1, indicating that the company is generating enough free cash flow relative to net income, but the negative growth in free cash flow is concerning.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue84.39M23.61M27.46M10.16M28.65M13.29M
Gross Profit68.06M16.20M24.52M9.94M26.59M11.98M
EBITDA69.88M-76.40M-43.54M-25.53M-7.89M-5.43M
Net Income34.46M-105.51M-46.05M-26.77M-8.55M-12.76M
Balance Sheet
Total Assets270.12M178.13M172.33M115.53M132.94M11.21M
Cash, Cash Equivalents and Short-Term Investments54.44M69.50M67.74M82.85M112.35M4.21M
Total Debt62.72M60.30M43.77M14.12M1.61M70.35M
Total Liabilities136.95M138.46M110.46M40.22M5.82M77.62M
Stockholders Equity133.16M39.67M61.86M75.12M127.12M-66.41M
Cash Flow
Free Cash Flow-24.23M-69.67M-33.83M-18.81M10.34M-1.97M
Operating Cash Flow-23.36M-69.67M-33.53M-18.72M10.44M-1.94M
Investing Cash Flow12.43M-22.16M-17.39M-36.72M-15.52M-33.00K
Financing Cash Flow10.31M82.11M28.46M8.35M113.11M2.74M

Zevra Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price8.81
Price Trends
50DMA
9.56
Negative
100DMA
10.06
Negative
200DMA
8.99
Negative
Market Momentum
MACD
-0.14
Positive
RSI
35.71
Neutral
STOCH
16.59
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ZVRA, the sentiment is Negative. The current price of 8.81 is below the 20-day moving average (MA) of 10.50, below the 50-day MA of 9.56, and below the 200-day MA of 8.99, indicating a bearish trend. The MACD of -0.14 indicates Positive momentum. The RSI at 35.71 is Neutral, neither overbought nor oversold. The STOCH value of 16.59 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for ZVRA.

Zevra Therapeutics Risk Analysis

Zevra Therapeutics disclosed 67 risk factors in its most recent earnings report. Zevra Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Zevra Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
61
Neutral
$511.74M13.9734.81%240.47%
52
Neutral
$542.61M-2.03-67.63%-91.16%-112.24%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
$483.32M-3.99-45.92%1255.21%74.58%
47
Neutral
$446.60M-289.93%14.26%-23.34%
44
Neutral
$328.39M-86.83%17.88%
41
Neutral
$584.01M-35.82%79.27%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ZVRA
Zevra Therapeutics
8.81
-0.19
-2.11%
LXRX
Lexicon Pharmaceuticals
1.25
-0.02
-1.57%
PRTA
Prothena
10.56
-7.14
-40.34%
OCGN
Ocugen
1.36
0.37
37.37%
CRVS
Corvus Pharmaceuticals
7.60
-1.85
-19.58%
SLDB
Solid Biosciences
4.06
-1.81
-30.83%

Zevra Therapeutics Corporate Events

Zevra Therapeutics Reports Strong Q3 Earnings and Strategic Growth
Nov 7, 2025

The recent earnings call of Zevra Therapeutics, Inc. painted a picture of strong performance and strategic advancements, particularly highlighting the success of MIPLYFFA. Despite facing challenges with OLPRUVA and slow enrollment in the DiSCOVER trial, the company maintains a robust financial position, which supports its future strategic goals.

Zevra Therapeutics Reports Strong Q3 2025 Revenue Growth
Nov 6, 2025

Zevra Therapeutics, Inc. is a commercial-stage company dedicated to developing therapies for rare diseases, with a focus on innovative, data-driven strategies to address unmet medical needs.

Zevra Therapeutics Faces $58.7 Million Impairment Charge, Raising Concerns Over Financial Stability
Aug 14, 2025

Zevra Therapeutics, Inc. has recently recognized an impairment charge of $58.7 million related to its definite-lived intangible assets for the quarter ending June 30, 2025. This financial adjustment highlights the potential risk of further impairments, which could adversely impact the company’s operating results. The evaluation of potential impairment involves significant judgment, considering factors such as changes in asset utilization, economic trends, and performance metrics. Future impairments could arise from these variables, posing a risk to the company’s financial stability.

Zevra Therapeutics’ Earnings Call: Optimism Amid Challenges
Aug 14, 2025

Zevra Therapeutics, Inc. recently held its earnings call, revealing a cautiously optimistic outlook for the company. The discussion highlighted strong revenue growth and strategic transactions, particularly the successful launch of MIPLYFFA and efforts to expand into the European market. However, challenges such as limited adoption of OLPRUVA and related financial impairments were also noted, tempering the overall positive sentiment.

Zevra Therapeutics Reports Strong Q2 2025 Results
Aug 13, 2025

Zevra Therapeutics, Inc. is a commercial-stage company dedicated to developing therapies for rare diseases, leveraging unique data-driven strategies to address complex drug development challenges.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 07, 2025