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Appili Therapeutics Inc Class A (TSE:APLI)
:APLI

Appili Therapeutics Inc Class A (APLI) AI Stock Analysis

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Appili Therapeutics Inc Class A

(OTC:APLI)

47Neutral
Appili Therapeutics faces significant financial instability with declining revenues and negative equity, which heavily impacts its overall stock score. While technical indicators show some stabilization, the valuation remains challenging due to ongoing losses. Positive corporate events provide potential upside, but the overall outlook is dampened by financial and operational challenges.

Appili Therapeutics Inc Class A (APLI) vs. S&P 500 (SPY)

Appili Therapeutics Inc Class A Business Overview & Revenue Model

Company DescriptionAppili Therapeutics Inc Class A (APLI) is a biopharmaceutical company focused on the development and commercialization of novel therapeutics targeting infectious diseases. The company operates in the healthcare sector and is dedicated to addressing significant unmet medical needs in the field of infectious disease treatment through its innovative pipeline of drug candidates.
How the Company Makes MoneyAppili Therapeutics Inc primarily generates revenue through the development and commercialization of its drug candidates. The company's revenue streams include milestone payments, royalties, and potential licensing agreements with pharmaceutical partners. Appili may also receive government grants or funding to support the research and development of its therapeutic products. Strategic partnerships and collaborations with other pharmaceutical companies play a crucial role in advancing its drug pipeline and securing financial resources necessary for clinical trials and commercialization efforts.

Appili Therapeutics Inc Class A Financial Statement Overview

Summary
Appili Therapeutics Inc Class A is facing significant financial challenges with declining revenues and profitability, high leverage, and negative equity. Cash flow remains under pressure with continued negative free cash flow. The company needs strategic improvements to stabilize its financial position and return to growth.
Income Statement
25
Negative
The company shows declining revenue with a significant decrease from $1.39M in 2022 to $124.7K in TTM (Trailing-Twelve-Months) 2024. Gross profit margin remains relatively high at 94.72% for TTM 2024, but the net and EBIT margins are severely negative due to high operational losses. The revenue growth rate is negative, indicating a contraction in business activities.
Balance Sheet
15
Very Negative
The balance sheet is concerning with negative stockholders' equity of -$13.63M in TTM 2024, indicating liabilities exceed assets. The debt-to-equity ratio cannot be calculated due to negative equity, highlighting financial instability. The equity ratio is negative due to the large accumulated deficit.
Cash Flow
30
Negative
The company exhibits negative free cash flow consistent with its net losses, with a minor reduction in negative free cash flow from 2023 to TTM 2024. Operating cash flow is negative, indicating cash outflows from core operations. There is an absence of free cash flow growth, reflecting ongoing challenges in generating cash.
Breakdown
TTMMar 2024Mar 2023Mar 2022Mar 2021Mar 2020
Income StatementTotal Revenue
124.75K827.41K334.18K1.39M0.00199.11K
Gross Profit
114.09K827.41K327.91K1.39M-14.84K199.11K
EBIT
-1.92M-2.16M-7.91M-24.68M-16.30M-6.13M
EBITDA
-1.28M-2.10M-8.19M-24.31M-14.87M-5.63M
Net Income Common Stockholders
-3.96M-3.78M-9.24M-25.12M-14.33M-5.42M
Balance SheetCash, Cash Equivalents and Short-Term Investments
94.49K94.49K2.47M6.66M16.12M10.54M
Total Assets
1.49M1.49M3.13M8.28M18.32M11.17M
Total Debt
8.18M8.18M7.67M4.98M1.03M1.00M
Net Debt
8.09M8.09M5.20M-1.69M-10.03M-9.50M
Total Liabilities
12.42M12.42M10.53M11.55M5.56M2.33M
Stockholders Equity
-10.92M-10.92M-7.40M-3.27M12.75M8.85M
Cash FlowFree Cash Flow
-641.51K-2.49M-10.10M-19.08M-11.46M-4.26M
Operating Cash Flow
-639.15K-2.46M-10.10M-19.08M-11.45M-4.26M
Investing Cash Flow
-1.71K-29.06K-3.17K5.06M-4.99M-1.14K
Financing Cash Flow
220.56K122.05K5.91M9.56M17.02M9.36M

Appili Therapeutics Inc Class A Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.02
Price Trends
50DMA
0.03
Negative
100DMA
0.03
Negative
200DMA
0.03
Negative
Market Momentum
MACD
>-0.01
Negative
RSI
48.22
Neutral
STOCH
<0.01
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TSE:APLI, the sentiment is Negative. The current price of 0.02 is below the 20-day moving average (MA) of 0.03, below the 50-day MA of 0.03, and below the 200-day MA of 0.03, indicating a bearish trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 48.22 is Neutral, neither overbought nor oversold. The STOCH value of <0.01 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for TSE:APLI.

Appili Therapeutics Inc Class A Peers Comparison

Overall Rating
UnderperformOutperform
Sector (52)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
TSTHX
79
Outperform
C$412.48M3.5057.36%39.36%746.02%
TSMBX
68
Neutral
C$49.28M29.315.32%-4.67%-60.94%
TSDRT
62
Neutral
$176.31M13.6631.34%-3.13%
52
Neutral
$5.19B3.04-44.20%2.82%16.59%-0.39%
47
Neutral
C$3.64M34.61%-89.15%25.91%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TSE:APLI
Appili Therapeutics Inc Class A
0.02
>-0.01
-33.33%
TSE:THX
Thor Explorations
0.67
0.40
148.15%
TSE:DRT
DIRTT Environmental Solutions
0.90
0.25
38.46%
TSE:MBX
Microbix Biosystms
0.34
0.02
6.25%

Appili Therapeutics Inc Class A Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
Appili Therapeutics Advances Tularemia Vaccine Research
Positive
May 1, 2025

Appili Therapeutics announced the publication of a manuscript in Frontiers in Bacteriology, highlighting the potential of their biodefense vaccine, ATI-1701, in preventing tularemia outbreaks. The review consolidates recent findings on immune responses to Francisella tularensis, the pathogen causing tularemia, and suggests pathways for effective vaccine development. ATI-1701 is positioned as a potentially valuable vaccine due to the lack of approved vaccines for tularemia in major markets, emphasizing its importance as a biodefense priority globally.

Spark’s Take on TSE:APLI Stock

According to Spark, TipRanks’ AI Analyst, TSE:APLI is a Neutral.

Appili Therapeutics Inc is facing significant financial instability, with declining revenues and negative equity being major concerns. Technical indicators show some stabilization, but bearish momentum and a challenging valuation due to negative earnings dampen the outlook. Positive corporate events, such as new patents and funding applications, offer potential upside, but the overall stock score remains low due to the prevailing financial difficulties.

To see Spark’s full report on TSE:APLI stock, click here.

Product-Related AnnouncementsBusiness Operations and Strategy
Appili Therapeutics Secures New Patents for LIKMEZ, Strengthening Market Position
Positive
Apr 28, 2025

Appili Therapeutics has announced the granting of new patents by the United States and Mexican patent offices for its oral formulation of metronidazole, LIKMEZ. These patents, which expire in 2039, enhance the protection of LIKMEZ by covering its unique taste-masked composition and therapeutic applications. This development is significant for Appili as it strengthens the company’s market position and supports the commercialization efforts of its partner, Saptalis Pharmaceuticals. The listing of the U.S. patent in the FDA’s Orange Book further solidifies the product’s market presence, with Saptalis planning a re-launch under its own label.

Spark’s Take on TSE:APLI Stock

According to Spark, TipRanks’ AI Analyst, TSE:APLI is a Underperform.

Appili Therapeutics faces significant financial instability with declining revenues and negative cash flows, which negatively impact its overall stock score. However, positive corporate events such as federal funding applications and strategic partnerships offer potential upside. Technical analysis suggests some stabilization, but the valuation remains challenging due to ongoing losses.

To see Spark’s full report on TSE:APLI stock, click here.

Private Placements and FinancingM&A TransactionsBusiness Operations and Strategy
Appili Therapeutics CEO to Discuss Strategic Growth and Funding Initiatives
Positive
Apr 2, 2025

Appili Therapeutics announced that its CEO, Don Cilla, will join Aditxt’s CEO for a discussion on emerging infectious diseases and strategic partnerships. The event will highlight Appili’s operational achievements, including $117 million in new federal funding applications, and the ongoing going-private transaction with Aditxt. The discussion will also emphasize Appili’s success in securing non-dilutive funding and its plans to accelerate the development of treatments for infectious diseases.

Private Placements and FinancingBusiness Operations and Strategy
Appili Therapeutics Seeks $117.5 Million in Federal Funding for Infectious Disease Treatments
Positive
Mar 18, 2025

Appili Therapeutics announced the submission of four new U.S. federal funding proposals totaling $117.5 million, aimed at advancing treatments for infectious diseases. The company also updated its transaction with Aditxt and extended the deadline for its going-private transaction. Appili’s strategic moves, including joining the Medical CBRN Defense Consortium, highlight its commitment to U.S. biodefense and preparedness, positioning it as a key player in developing medical countermeasures.

Product-Related AnnouncementsM&A TransactionsFinancial Disclosures
Appili Therapeutics Advances Pipeline with Strong Shareholder and Government Support
Positive
Feb 14, 2025

Appili Therapeutics reported its third-quarter fiscal results, highlighting significant shareholder support for a take-private transaction with Aditxt and progress in its key pipeline programs. The company is advancing ATI-1701, a biodefense vaccine candidate with substantial U.S. government backing, and ATI-1801, a topical antiparasitic product with FDA alignment on development requirements. Additionally, Appili has launched LIKMEZ™, an FDA-approved liquid formulation of metronidazole, in partnership with Saptalis Pharmaceuticals, addressing challenges in oral drug compliance.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.