Silence Therapeutics (SLN) AI Stock Analysis

• Market Cap: $307.49M
• Dividend Yield: N/A
• Average Volume (3M): 101.05K
• Price to Earnings (P/E): ―
• Beta (1Y): 1.32
• Revenue Growth: N/A
• EPS Growth: N/A
• Country: US
• Employees: 116
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.19
• Shares Outstanding: 47,233,948
• 10 Day Avg. Volume: 169,902
• 30 Day Avg. Volume: 101,050
• PEG Ratio: N/A
• Price to Book (P/B): N/A
• Price to Sales (P/S): N/A
• P/FCF Ratio: N/A
• Enterprise Value/Market Cap: 0.52
• Enterprise Value/Revenue: 6.18
• Enterprise Value/Gross Profit: 7.50
• Enterprise Value/Ebitda: -2.83
• 1Y Price Target: $50.00
• Price Target Upside: 668.05% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 3
• EPS Forecast (FY): N/A
• Revenue Forecast (FY): N/A

• Rating: 54 Neutral
• Price Target: $6.50 ▼(-0.15% Downside)

The overall stock score is primarily influenced by financial performance challenges, including negative profitability and equity. Technical analysis provides some positive momentum, but valuation remains a concern with a negative P/E ratio. The absence of earnings call and corporate events data limits additional insights.

Positive Factors

Revenue Growth

The company has demonstrated significant revenue growth, indicating strong demand for its RNAi therapeutics and potential for future expansion.

Strategic Collaborations

Collaborations with pharmaceutical companies provide a steady revenue stream and enhance research capabilities, supporting long-term growth.

Pipeline Advancement

Advancing clinical trials, such as the SANRECO Phase 2 study, strengthens Silence Therapeutics' pipeline, enhancing future revenue potential.

Negative Factors

Profitability Challenges

Ongoing profitability issues, with negative EBIT and net income margins, indicate challenges in cost management and achieving sustainable profits.

Negative Equity

Negative equity reflects financial instability, posing risks to long-term viability and limiting the company's ability to leverage for growth.

Cash Flow Challenges

Consistently negative free cash flow highlights liquidity issues, potentially hindering operational flexibility and investment in growth initiatives.

Silence Therapeutics Business Overview & Revenue Model

Company Description

Silence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company's platform includes mRNAi GalNAc Oligonucleotide Discovery platform designed to accurately target specific disease-associated genes in the liver. It designs short interfering RNA molecules to harness the body's natural mechanism of RNA interference, and degrading messenger RNA molecules that encode specific targeted disease-associated proteins in a cell. The company is developing various product candidates, including SLN360, which is Phase I clinical trials for the treatment of cardiovascular disease with high lipoprotein; SLN124 that is in Phase I clinical trials for the treatment of non-transfusion dependent thalassemia, and Phase I clinical trials for the treatment of myelodysplastic syndrome; and SLN124 for the treatment of polycythemia vera. It has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize small interfering RNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and Mallinckrodt Pharma IP Trading DAC to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders. The company also has a collaboration with Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three undisclosed targets leveraging Silence's mRNAi GOLD platform. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc is headquartered in London, the United Kingdom.

How the Company Makes Money

Silence Therapeutics generates revenue primarily through collaboration agreements and partnerships with pharmaceutical companies. These collaborations typically involve upfront payments, milestone payments tied to the progression of drug candidates through clinical development, and royalties on future product sales. The company also seeks funding through grants and research contracts that support its therapeutic development programs. Additionally, advancements in its pipeline and successful clinical trial outcomes can significantly enhance its revenue potential through licensing agreements or partnerships for commercialization.

Silence Therapeutics Financial Statement Overview

Summary

Silence Therapeutics shows revenue growth but struggles with profitability, negative equity, and cash flow challenges. The financial instability is a significant concern, requiring strategic improvements in cost management and financial planning.

Income Statement

Silence Therapeutics has demonstrated significant revenue growth over the years, with a notable increase from 2023 to 2024. However, the company continues to face challenges with profitability, as evidenced by negative EBIT and net income margins. The consistent negative profit margins highlight a need for enhanced cost management or increased revenue to achieve profitability.

Balance Sheet

The company's balance sheet reveals a concerning negative stockholders' equity as of 2024, indicating financial instability. The debt-to-equity ratio is not favorable due to the negative equity, and although the company maintains substantial cash reserves, the high liabilities present a risk. Improving equity and managing liabilities are critical for financial health.

Cash Flow

Silence Therapeutics has managed significant financing cash flow, which supports its operations despite negative operating cash flow. The free cash flow has been consistently negative, reflecting ongoing cash challenges. However, the company's ability to secure financing offers some operational flexibility. Improving free cash flow is essential for sustainable growth.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	25.84M	43.26M	25.38M	17.50M	12.41M	5.48M
Gross Profit	21.32M	31.45M	15.06M	6.62M	4.96M	1.72M
EBITDA	-56.55M	-48.99M	-49.78M	-47.88M	-45.42M	-35.53M
Net Income	-68.72M	-45.31M	-43.27M	-40.49M	-39.41M	-32.55M
Balance Sheet
Total Assets	165.23M	202.63M	93.82M	107.50M	96.19M	85.97M
Cash, Cash Equivalents and Short-Term Investments	114.16M	147.33M	54.03M	71.14M	73.54M	37.45M
Total Debt	0.00	117.00K	272.00K	446.00K	137.00K	341.00K
Total Liabilities	71.08M	68.61M	76.77M	85.43M	87.67M	76.91M
Stockholders Equity	94.16M	134.02M	17.05M	22.07M	8.53M	9.06M
Cash Flow
Free Cash Flow	-78.77M	-67.85M	-39.40M	-45.90M	5.47M	-11.29M
Operating Cash Flow	-78.61M	-67.64M	-39.35M	-45.46M	6.81M	-10.78M
Investing Cash Flow	-6.66M	-21.97M	16.43M	-16.54M	8.68M	9.62M
Financing Cash Flow	25.86M	142.09M	25.16M	43.05M	30.71M	15.43M

Silence Therapeutics Technical Analysis

• Technical Analysis Sentiment: Neutral
• Last Price: 6.51
• 50DMA: Positive
• 100DMA: Positive
• 200DMA: Positive
• MACD: Positive
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SLN, the sentiment is Neutral. The current price of 6.51 is below the 20-day moving average (MA) of 6.59, above the 50-day MA of 5.69, and above the 200-day MA of 5.02, indicating a neutral trend. The MACD of 0.40 indicates Positive momentum. The RSI at 51.53 is Neutral, neither overbought nor oversold. The STOCH value of 22.80 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for SLN.

Silence Therapeutics Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
SLN	54 Neutral	$307.49M	-3.89	―	―	―	―
Sector *	51 Neutral	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
ABEO	50 Neutral	$233.83M	7.23	48.34%	―	―	―
IMAB	45 Neutral	―	―	―	―	-100.00%	72.45%
HUMA	42 Neutral	$297.76M	―	―	―	―	63.92%
GALT	35 Underperform	$363.22M	-8.81	―	―	―	17.80%
VOR	33 Underperform	$140.65M	-0.08	―	―	―	-686.12%

Silence Therapeutics Corporate Events

Silence Therapeutics Completes Enrollment for Phase 2 Study

On October 23, 2025, Silence Therapeutics announced the completion of patient enrollment in the SANRECO Phase 2 study of divesiran for treating polycythemia vera (PV). This milestone reflects the growing interest in divesiran, a first-in-class siRNA targeting TMPRSS6, which aims to maintain hematocrit levels below 45% without phlebotomies. The study’s results are expected in the third quarter of 2026, potentially impacting the treatment landscape for PV, a condition with significant unmet needs.

The most recent analyst rating on (SLN) stock is a Hold with a $7.50 price target. To see the full list of analyst forecasts on Silence Therapeutics stock, see the SLN Stock Forecast page.

Michael Davidson Resigns from Silence Therapeutics Board

On August 11, 2025, Michael Davidson resigned from the board of directors of Silence Therapeutics plc to focus on his role as CEO of NewAmsterdam Pharma Company N.V. His departure was not due to any disagreements with the company. The board expressed gratitude for his contributions and reduced its size from five to four directors, appointing Iain Ross to fill the vacancy on the Audit and Risk Committee.

The most recent analyst rating on (SLN) stock is a Buy with a $40.00 price target. To see the full list of analyst forecasts on Silence Therapeutics stock, see the SLN Stock Forecast page.

Silence Therapeutics Reports Q2 2025 Progress and Financials

Silence Therapeutics is a global clinical-stage biotechnology company focused on developing innovative siRNA therapies to target and silence disease-associated genes, particularly in the liver, with a focus on areas of high unmet medical need such as cardiovascular disease, hematology, and rare diseases.