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PYXS Stock Chart & Stats
$3.06
$0.30(11.49%)
At close: 4:00 PM EDT
$3.06
$0.30(11.49%)
Day’s Range― - ―
52-Week Range$1.03 - $5.55
Previous CloseN/A
Volume197.33K
Average Volume (3M)1.24M
Market Cap
$210.47M
Enterprise Value$175.98M
Total Cash (Recent Filing)$33.00M
Total Debt (Recent Filing)$17.83M
Price to Earnings (P/E)―
Beta1.70
Next Earnings
Nov 17, 2026EPS Estimate
-0.28Next Dividend Ex-DateN/A
Dividend YieldN/A
Share Statistics
EPS (TTM)-1.41
Shares Outstanding119,583,630
10 Day Avg. Volume1,034,462
30 Day Avg. Volume1,243,301
Financial Highlights & Ratios
PEG Ratio0.30
Price to Book (P/B)1.34
Price to Sales (P/S)5.16
P/FCF Ratio-1.13
Enterprise Value/Market Cap0.84
Enterprise Value/Revenue15.94
Enterprise Value/Gross Profit15.98
Enterprise Value/Ebitda-2.11
Forecast
1Y Price Target
$9.00Price Target Upside194.12% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering7
EPS Forecast (FY)-1.22
Revenue Forecast (FY)$57.14K
Bulls Say, Bears Say
Bulls Say
MICVO Clinical EfficacyThe reported response and disease-control rates provide meaningful clinical validation for MICVO in recurrent or metastatic head and neck cancer. If durability and safety remain supportive, these results could strengthen the lead asset’s prospects for pivotal development and future partnering.
Path Toward Pivotal TrialAdvancing MICVO toward a pivotal Phase 3 study represents a substantial development milestone and creates a clearer route toward potential commercialization. Progress through FDA Project Optimus and planned regulatory interaction may also improve development discipline and trial execution.
Leadership StabilityReplacing interim leadership with a permanent CEO provides greater continuity while Pyxis advances MICVO through important clinical milestones. Civik’s prior senior experience at Genentech, Five Prime Therapeutics and other cancer-focused firms may support strategic and operational execution.
Bears Say
Persistent Operating LossesVery large operating and net losses show that the current business has not yet produced sustainable profitability. The gap between modest revenue and the cost base leaves earnings highly dependent on successful clinical progression, future financing and eventual commercial product launches.
Heavy Cash ConsumptionSubstantial negative operating and free cash flow indicate that Pyxis is consuming cash rather than funding operations internally. Continued investment in clinical development will likely require additional capital, making financial flexibility dependent on financing access and execution of the pipeline.
Weakening Balance SheetDebt at roughly 1.6 times equity and contracting total assets indicate a materially thinner financial cushion than in prior periods. This weaker balance sheet increases dependence on future funding and can constrain the company’s ability to absorb clinical setbacks or extend development timelines.
PYXS FAQ
What was Pyxis Oncology’s price range in the past 12 months?
Pyxis Oncology lowest stock price was $1.03 and its highest was $5.55 in the past 12 months.
What is Pyxis Oncology’s market cap?
Pyxis Oncology’s market cap is $210.47M.
When is Pyxis Oncology’s upcoming earnings report date?
Pyxis Oncology’s upcoming earnings report date is Nov 17, 2026 which is in 27 days.
How were Pyxis Oncology’s earnings last quarter?
Pyxis Oncology released its earnings results on Aug 13, 2026. The company reported -$0.4 earnings per share for the quarter, missing the consensus estimate of -$0.35 by -$0.05.
Is Pyxis Oncology overvalued?
According to Wall Street analysts Pyxis Oncology’s price is currently Undervalued.
Does Pyxis Oncology pay dividends?
Pyxis Oncology does not currently pay dividends.
What is Pyxis Oncology’s EPS estimate?
Pyxis Oncology’s EPS estimate is -0.28.
How many shares outstanding does Pyxis Oncology have?
Pyxis Oncology has 119,583,630 shares outstanding.
What happened to Pyxis Oncology’s price movement after its last earnings report?
Pyxis Oncology reported an EPS of -$0.4 in its last earnings report, missing expectations of -$0.35. Following the earnings report the stock price went down -5.346%.
Which hedge fund is a major shareholder of Pyxis Oncology?
Currently, no hedge funds are holding shares in PYXS
What is the TipRanks Smart Score and how is it calculated?
Smart Score combines eight research factors - such as analyst recommendations, hedge fund trends, and technical indicators - to measure a stock’s outlook. These signals are unified into a single score that reflects bullish or bearish momentum. See detailed methodology
Pyxis Oncology Stock Smart Score
Outperform
1
2
3
4
5
6
7
8
9
10
Analyst Consensus
Strong Buy
Average Price Target:
$9.00 (194.12% Upside)
$9.00 (194.12% Upside)
Blogger Sentiment
Neutral
PYXS Sentiment 50%
Sector Average 67%
Sector Average 67%
Hedge Fund Trend
Increased
By 524.0K Shares
Last Quarter.
Last Quarter.
Crowd Wisdom
Very Positive
Last 7 Days ▼ 1.0%
Last 30 Days ▲ 6.3%
Last 30 Days ▲ 6.3%
News Sentiment
Very Bullish
Bullish news 100%
Bearish news 0%
Bearish news 0%
Technicals
SMA
Positive
20 days / 200 days
Momentum
-47.61%
12-Months-Change
Fundamentals
Return on Equity
-215.23%
Trailing 12-Months
Asset Growth
-55.43%
Trailing 12-Months
Learn more about TipRanks Smart Score
Company Description
Pyxis Oncology
Pyxis Oncology, Inc. operates as a preclinical biopharmaceutical company focused on developing novel therapeutic approaches to combat various forms of cancer. Its investigational immune-oncology pipeline includes PYX-106, a fully human immunoglobulin G1 (IgG1) antibody designed to target siglec-15, which is being explored for its potential efficacy against thyroid cancer, head and neck squamous cell carcinoma, non-small cell lung cancer (NSCLC), and other solid tumors. Additionally, PYX-102 is an immune-therapeutic currently under investigation for the treatment of solid tumors. The company's portfolio also features a range of investigational antibody-drug conjugate (ADC) candidates: PYX-201, a novel ADC being developed for NSCLC, breast cancer, and other solid tumors; PYX-202, another novel ADC aimed at small cell lung cancer (SCLC), soft tissue sarcoma, and other solid tumors; and PYX-203, an ADC undergoing evaluation for acute myeloid leukemia and myeloid dysplastic syndrome. Pyxis Oncology was founded in 2018 and is based in Cambridge, Massachusetts.
PYXS Stock 12 Month Forecast
Average Price Target
$9.00
▲(194.12% Upside)
Technical Analysis
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Ownership Overview
14.49% Insiders
2.15% Mutual Funds
22.39% Other Institutional Investors
56.92% Public Companies and
Individual Investors










