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Oncotelic Therapeutics (OTLC) AI Stock Analysis

OTLC

Oncotelic Therapeutics

(Other OTC:OTLC)

Select Model
Rating:44Neutral
Price Target:$0.02â–²(6.25% Upside)
Action:reiterated
Date:10/28/26

The score is held down primarily by weak financial performance (minimal recurring revenue, persistent operating losses, and sustained cash burn with low earnings-to-cash conversion) and bearish technical trend signals (price below key moving averages with negative MACD). Valuation looks very low on P/E but is less persuasive given concerns that recent net income is not supported by core operations or cash flow, while corporate events are mixed with dilution risk from convertible financing.

Positive Factors
AI-driven oncology discoveryThe PLA framework gives Oncotelic a data-driven approach to oncology discovery, using large literature and biological datasets to identify research signals. Expansion through autonomous AI agents and extensive protein vectors could improve productivity and broaden the company’s future development pipeline.
Negative Factors
Minimal and inconsistent revenueMinimal and inconsistent revenue indicates that Oncotelic has not yet demonstrated a durable commercial base for its business model. This limits operating scale, makes results difficult to forecast, and leaves future progress dependent on successful development, partnering, or other non-recurring sources.

Oncotelic Therapeutics (OTLC) vs. SPDR S&P 500 ETF (SPY)

-100%-80%-60%-40%-20%0%20%OTLC-84.00%SPY+11.79%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
Market Cap
$9.15M
Dividend Yield
―
Average Volume (3M)
337.12K
Price to Earnings (P/E)
0.0
Beta (1Y)
-0.03
Revenue Growth
―
EPS Growth
―
Country
US
Employees
41
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Oncotelic Therapeutics Business Overview & Revenue Model

Company Description

Oncotelic Therapeutics, Inc., an Agoura Hills, California-based clinical-stage biopharmaceutical company, specializes in developing therapeutics for rare oncological conditions. Its flagship therapeutic candidate, OT-101 – an antisense compound desig...

Oncotelic Therapeutics Financial Statement Overview

Summary

Financial performance is weak: revenue is minimal and inconsistent, operating losses persist, and operating/free cash flow remain deeply negative (ongoing cash burn). The unusually high TTM net income appears driven by non-operating or one-time items and does not align with operating trends or cash generation, reducing earnings quality. The balance sheet shows improved recent leverage, but historical volatility and swings in returns raise stability risk.

Income Statement

18Very Negative

Balance Sheet

45Neutral

Cash Flow

12Very Negative
Financial statement breakdown
BreakdownTTMMar 2026Mar 2025Dec 2023Mar 2023Mar 2022
Income Statement
Total Revenue250.00K0070.00K00
Gross Profit250.00K0070.00K-12.84K-61.51K
EBITDA360.34M361.46M-3.80M-6.86M-5.60M-9.06M
Net Income247.50M249.28M-4.52B-7.90M17.82M-11.39M
Balance Sheet
Total Assets394.75M393.09M26.68M30.01M36.12M23.61M
Cash, Cash Equivalents and Short-Term Investments186.01K88.86K86.13K170.41K241.45K568.77K
Total Debt13.89M13.91M13.09M12.57M11.26M8.99M
Total Liabilities131.31M131.36M19.20M18.40M16.92M15.45M
Stockholders Equity264.56M262.76M8.25M12.13M19.41M7.96M
Cash Flow
Free Cash Flow-1.52M-1.38M-740.27K-1.32M-1.45M-4.43M
Operating Cash Flow-1.52M-1.38M-740.27K-1.32M-1.45M-4.43M
Investing Cash Flow000000
Financing Cash Flow1.62M1.39M656.00K1.25M1.13M4.53M

Oncotelic Therapeutics Technical Analysis

Technical Analysis SentimentNegative
Last Price0.02

Price Trends

50DMA0.02Negative
100DMA0.03Negative
200DMA0.04Negative

Market Momentum

MACD-0.00Negative
RSI39.10Neutral
STOCH72.22Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For OTLC, the sentiment is Negative. The current price of 0.02 is below the 20-day moving average (MA) of 0.02, below the 50-day MA of 0.02, and below the 200-day MA of 0.04, indicating a neutral trend. The MACD of -0.00 indicates Negative momentum. The RSI at 39.10 is Neutral, neither overbought nor oversold. The STOCH value of 72.22 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for OTLC.

Oncotelic Therapeutics Risk Analysis

Oncotelic Therapeutics disclosed 38 risk factors in its most recent earnings report. Oncotelic Therapeutics reported the most risks in the "Finance & Corporate" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy

Latest Risks Added

0 New Risks

Oncotelic Therapeutics Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

OTLC against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
GRCEGRCE48Neutral$40.81M-1.54-35.78%――-43.60%
CALCCALC44Neutral$9.97M-0.213398.40%――15.37%
MAIAMAIA44Neutral$67.92M-1.74-211.15%――-7.28%
OTLCOTLC44Neutral$7.48M0.03123.80%―――
ELUTELUT40Underperform$37.07M0.64940.81%―-48.76%-3.02%
LTRNLTRN39Underperform$9.87M-0.41-456.35%――9.68%

* Healthcare Sector Average

Performance Comparison

-50%0%50%100%150%OTLCGRCELTRNCALCELUTMAIADec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
OTLC and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
OTLCOncotelic Therapeutics Inc0.02-0.09-84.76%
GRCEGrace Therapeutics, Inc.1.94-1.17-37.62%
LTRNLantern Pharma, Inc.0.66-3.16-82.72%
CALCCalcimedica, Inc.1.46-13.49-90.23%
ELUTElutia Inc.0.84-0.10-10.48%
MAIAMAIA Biotechnology, Inc.1.10-0.06-5.17%

Oncotelic Therapeutics Corporate Events

Business Operations and Strategy

Oncotelic showcases AI-driven oncology discovery framework

Positive
Oct 26, 2026

On October 22, 2026, Oncotelic Therapeutics Chief Business Officer Saran Saund presented the company’s Partitioned Literature Aggregation framework at the 22nd Drug Discovery Strategic Summit in Millbrae, California. The talk detailed how parti...

Business Operations and StrategyProduct-Related Announcements

Oncotelic highlights PDAOAI platform and BIO REBOOT initiative

Positive
Oct 13, 2026

On October 7 and 8, 2026, Oncotelic Therapeutics representatives presented new technical details of their PDAOAI data-analytics platform and hepatocellular carcinoma research at the Drug Discovery 2026 conference in Burlingame, California. The platfo...

Business Operations and StrategyPrivate Placements and Financing

Oncotelic Announces New Convertible Note Financing Agreement

Negative
Aug 4, 2026

On August 3, 2026, Oncotelic Therapeutics entered into a Securities Purchase Agreement with Pacific Pier Capital II, LP, issuing a $178,410 convertible promissory note with a 12% original issue discount and 12% annual interest. The note can be conver...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Oct 28, 2026