Clinical EfficacyThe company reported additional signals of clinical efficacy with MP0533, some evidence of dose response, and good enough tolerability to proceed to higher dose levels.
Mechanism Of ActionEngaging single-TAA expressing blasts will broaden MP033’s killing potential and support a new MoA thesis for MP0533 – broadest CD3 TCE as competitors target one TAA at a time.
Patient OutcomesSeven of the nine patients in dose regimen cohort 6 are continuing treatment, and one patient is in a morphologic leukemic-free state (MLFS).