Krystal Biotech stock analysis
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Krystal Biotech (KRYS) Stock Price & Analysis
KRYS Stock Chart & Stats
- Day’s Range
- $303.59 - $311.05
- 52-Week Range
- $198.02 - $382.54
- Previous Close
- $306.50
- Volume
- N/A
- Average Volume (3M)
- 315.23K
- Market Cap
- $9.08B
- Enterprise Value
- $9.35B
- Total Cash (Recent Filing)
- $911.85M
- Total Debt (Recent Filing)
- $8.59M
- Price to Earnings (P/E)
- 40.3
- Beta
- 0.55
- Next Earnings
- Mar 01, 2027 (Est.)
- EPS Estimate
- 2.04
- Next Dividend Ex-Date
- N/A
- Dividend Yield
- N/A
Bulls Say, Bears Say
Bulls Say
VYJUVEK Commercial Momentum
Strong VYJUVEK growth and cumulative revenue demonstrate meaningful patient treatment and physician adoption. Continued reimbursement approvals, prescriber additions, and utilization can support durable commercial expansion and reinforce the product’s position in its rare-disease market.
Strong Cash Generation And Liquidity
High operating and free cash flow, together with substantial liquidity, gives Krystal financial flexibility to fund clinical development, international launches, and commercial infrastructure without relying heavily on debt. Strong cash conversion also supports the quality and durability of reported earnings.
International And Pipeline Expansion
Progress across international market access and several HSV-1-based programs broadens Krystal’s future growth opportunities beyond current US sales. Additional geographic launches and potential new indications could diversify revenue and extend the platform’s commercial runway over time.
Bears Say
Gross-margin Pressure Overseas
The lower gross margin shows that geographic expansion can initially dilute product economics when manufacturing improvements are not yet applied across regions. If international sales become a larger revenue share before optimization, this mix effect could constrain margin expansion.
Clinical Development Delays
Delayed clinical readouts extend the time before pipeline programs can support regulatory filings or commercial revenue. Longer development timelines also defer potential diversification from VYJUVEK and require continued investment while outcomes remain dependent on future trial execution.
Historical Earnings And Cash-flow Volatility
The recent profitability inflection is encouraging, but prior losses and negative cash flow show that earnings power has not yet been tested across a long operating history. Sustaining results therefore depends on continued VYJUVEK commercial momentum and successful execution.
Krystal Biotech News
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Krystal Biotech Stock Smart Score
Company Description
Krystal Biotech
Krystal Biotech, Inc. is a clinical-stage biotechnology company focused on developing redosable gene therapies to address severe orphan diseases across the United States. Its most advanced therapeutic candidate, beremagene geperpavec (B-VEC), is currently undergoing Phase III clinical evaluation for the treatment of dystrophic epidermolysis bullosa. The company's pipeline also includes several other promising programs: KB105 is in Phase I/II clinical trials for patients suffering from deficient autosomal recessive congenital ichthyosis; KB301 is also in Phase I/II development, aiming to ameliorate wrinkles and other signs of aging or damaged skin. Additionally, Krystal Biotech is conducting preclinical research on KB407 for cystic fibrosis and KB104 for Netherton syndrome. In its earlier discovery phase, the company is exploring candidates such as KB5xx for chronic skin conditions and multiple KB3xx programs targeting aesthetic dermatological concerns. Krystal Biotech, Inc. was established in 2015 and is based in Pittsburgh, Pennsylvania.
- Sector
- Healthcare
- Industry
- Biotechnology
- CEO
- Krish S. Krishnan
- Employees
- 295
- Website
- www.krystalbio.com
- Address
- 2100 Wharton Street, Pittsburgh, PA, 15203, US
Krystal Biotech (KRYS) Earnings & Revenues
KRYS Company Deck
KRYS Earnings Call
Earnings Call SentimentPositive
The call was strongly positive, supported by 30% VYJUVEK revenue growth, substantial cash and profitability, continued US and international commercial expansion, encouraging Gorlin syndrome data, and broad pipeline progress. The main negatives were lower gross margin and year-over-year net income, along with delayed or slower enrollment and readouts in several clinical programs. Management nevertheless characterized the studies as progressing well and maintained multiple 2027 development milestones.
View all KRYS earnings summariesKRYS Stock 12 Month Forecast
Average Price Target
Technical Analysis
Overall Consensus
| Indicator | Bullish | Neutral | Bearish |
|---|---|---|---|
| Overall Consensus | 7 | 5 | 10 |
| Technical Analysis | 3 | 5 | 2 |
| Moving Averages | 4 | 0 | 8 |













