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Heartseed, Inc. (JP:219A)
:219A
Japanese Market
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Heartseed, Inc. (219A) AI Stock Analysis

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JP:219A

Heartseed, Inc.

(219A)

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Neutral 45 (OpenAI - 4o)
Rating:45Neutral
Price Target:
¥1,361.00
▼(-25.63% Downside)
Heartseed, Inc. faces significant challenges with profitability and cash flow management despite strong revenue growth. The technical indicators suggest a bearish trend, and the high P/E ratio indicates potential overvaluation. The absence of earnings call data and corporate events limits additional insights.

Heartseed, Inc. (219A) vs. iShares MSCI Japan ETF (EWJ)

Heartseed, Inc. Business Overview & Revenue Model

Company DescriptionHeartseed, Inc. is a biotechnology company focused on developing innovative therapies for cardiovascular diseases. With a commitment to transforming the treatment landscape, Heartseed specializes in regenerative medicine and stem cell technology, aiming to restore heart function and improve patient outcomes. The company operates within the healthcare sector, leveraging cutting-edge research and clinical trials to bring its core products, including advanced cellular therapies and drug candidates, to market.
How the Company Makes MoneyHeartseed, Inc. generates revenue primarily through the development and commercialization of its therapeutic products. The company’s revenue model includes several key streams: licensing agreements with pharmaceutical companies, grant funding for research and development, and potential milestone payments associated with clinical trial progress. Additionally, partnerships with academic institutions and healthcare organizations enhance its research capabilities and may provide funding opportunities. As the company advances its products through clinical trials and approaches regulatory approval, it stands to gain substantial financial returns from product sales and royalties.

Heartseed, Inc. Financial Statement Overview

Summary
Heartseed, Inc. shows strong revenue growth but struggles with profitability and cash flow management. The balance sheet is robust with minimal leverage, yet operational inefficiencies and cash flow issues pose risks.
Income Statement
30
Negative
Heartseed, Inc. shows a significant increase in total revenue from the previous year, demonstrating strong growth potential. However, the company faces challenges with negative EBIT and EBITDA margins, indicating operational inefficiencies. The net profit margin is also negative, reflecting ongoing unprofitability.
Balance Sheet
50
Neutral
The company maintains a strong equity position with an equity ratio of 93.7%, indicating financial stability. The debt-to-equity ratio is low at 0.001, suggesting minimal leverage risk. However, the high net loss impacts the return on equity negatively.
Cash Flow
35
Negative
Operating cash flow remains negative, highlighting cash management challenges. The company has a negative free cash flow, although it improved slightly from the previous year. The operating cash flow to net income ratio is below 1, suggesting inefficiencies in converting revenue into cash.
BreakdownTTMDec 2024Dec 2023Dec 2022
Income Statement
Total Revenue2.64B873.61M344.73M499.06M
Gross Profit2.61B873.61M344.73M499.06M
EBITDA610.27M-776.36M-1.45B-1.41B
Net Income519.32M-812.73M-1.47B-1.41B
Balance Sheet
Total Assets7.71B7.07B5.72B4.94B
Cash, Cash Equivalents and Short-Term Investments6.92B5.30B4.59B3.99B
Total Debt2.04M5.39M11.58M30.98M
Total Liabilities508.69M444.35M450.19M208.45M
Stockholders Equity7.20B6.62B5.27B4.73B
Cash Flow
Free Cash Flow0.00-1.41B-1.13B-1.92B
Operating Cash Flow0.00-1.34B-797.93M-1.92B
Investing Cash Flow0.00-67.13M-425.69M-994.00K
Financing Cash Flow0.002.12B1.85B-22.16M

Heartseed, Inc. Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1830.00
Price Trends
50DMA
2717.76
Negative
100DMA
3013.95
Negative
200DMA
2633.89
Negative
Market Momentum
MACD
-260.70
Negative
RSI
35.18
Neutral
STOCH
22.05
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JP:219A, the sentiment is Negative. The current price of 1830 is above the 20-day moving average (MA) of 1803.70, below the 50-day MA of 2717.76, and below the 200-day MA of 2633.89, indicating a bearish trend. The MACD of -260.70 indicates Negative momentum. The RSI at 35.18 is Neutral, neither overbought nor oversold. The STOCH value of 22.05 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JP:219A.

Heartseed, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
71
Outperform
¥31.36B9.496.75%-3.11%-13.09%
58
Neutral
¥19.33B-48.16-5.65%-469.19%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
¥16.96B-8.775.58%
45
Neutral
¥39.76B75.52
45
Neutral
¥76.11B-31.763.47%7.15%-454.41%
33
Underperform
¥55.07B-82.471242.62%2.56%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
JP:219A
Heartseed, Inc.
1,743.00
461.00
35.96%
JP:4552
JCR Pharmaceuticals Co., Ltd.
615.00
-39.28
-6.00%
JP:4595
Mizuho Medy Co., Ltd.
1,646.00
118.15
7.73%
JP:4599
StemRIM Inc.
273.00
-82.00
-23.10%
JP:4894
Cuorips Inc.
6,690.00
-590.00
-8.10%
JP:7774
Japan Tissue Engineering Co., Ltd.
476.00
-27.00
-5.37%

Heartseed, Inc. Corporate Events

Heartseed Inc. Addresses Partnership Termination and Future Strategies
Oct 2, 2025

Heartseed Inc. announced the termination of its partnership with Novo Nordisk A/S, which was initially a significant collaboration in the cell therapy field. The company is addressing investor concerns about the impact on its stock price and future partnerships, emphasizing its recognition in the international market and the need for careful consideration in forming new alliances to enhance corporate value.

The most recent analyst rating on (JP:219A) stock is a Hold with a Yen3290.00 price target. To see the full list of analyst forecasts on Heartseed, Inc. stock, see the JP:219A Stock Forecast page.

Heartseed Inc. Advances Cardiac Therapy with New Clinical Trial Submission
Oct 1, 2025

Heartseed Inc. has announced the submission of a clinical trial notification to Japan’s Pharmaceuticals and Medical Devices Agency for its HS-005 therapy, marking a significant step towards treating severe heart failure. The trial aims to assess the safety and efficacy of the therapy in 14 patients, with plans to begin treatment in 2026, reflecting the company’s strategic progress in advancing regenerative cardiac therapies.

The most recent analyst rating on (JP:219A) stock is a Hold with a Yen3290.00 price target. To see the full list of analyst forecasts on Heartseed, Inc. stock, see the JP:219A Stock Forecast page.

Heartseed, Inc. Ends Partnership with Novo Nordisk, Maintains Development Plans
Oct 1, 2025

Heartseed, Inc. announced the termination of its partnership with Novo Nordisk A/S, clarifying that no penalty will be incurred from the termination. The company retains its milestone payments and continues its development plans for its therapeutic programs in Japan, with no impact on its financial stability for upcoming clinical trials. The overseas strategy is under review, and the company will disclose further information in due course. Despite concerns about potential information leaks and stock trading volumes, Heartseed asserts no correlation between these events and the termination announcement.

The most recent analyst rating on (JP:219A) stock is a Hold with a Yen3290.00 price target. To see the full list of analyst forecasts on Heartseed, Inc. stock, see the JP:219A Stock Forecast page.

Heartseed Inc. Ends Partnership with Novo Nordisk, Shifts Focus to Japan
Sep 30, 2025

Heartseed Inc. announced the termination of its exclusive worldwide collaboration and license agreement with Novo Nordisk A/S, as Novo Nordisk shifts focus to its core business areas. The termination impacts Heartseed’s overseas business strategy and intellectual property management, but does not affect its ongoing clinical trials or technology development. The company will now receive 100% of sales revenue in Japan and plans to continue its development efforts domestically while exploring new overseas partnerships.

The most recent analyst rating on (JP:219A) stock is a Hold with a Yen3290.00 price target. To see the full list of analyst forecasts on Heartseed, Inc. stock, see the JP:219A Stock Forecast page.

Heartseed Regains Rights After Novo Nordisk Partnership Ends
Sep 30, 2025

Heartseed Inc. announced the termination of its partnership with Novo Nordisk A/S, which decided to concentrate on its core business areas. As a result, Heartseed regains worldwide rights to its therapeutic programs HS-001 and HS-005 for severe heart failure. The company maintains its earnings forecast for 2025 and reports no safety or efficacy concerns for HS-001, with HS-005 clinical preparations progressing as planned.

The most recent analyst rating on (JP:219A) stock is a Hold with a Yen3290.00 price target. To see the full list of analyst forecasts on Heartseed, Inc. stock, see the JP:219A Stock Forecast page.

Heartseed Inc. Partners with Japan Lifeline for Clinical Trial Delivery System
Sep 11, 2025

Heartseed Inc. has announced a collaboration with Japan Lifeline Co., Ltd. for the supply of a delivery catheter system, which is crucial for their HS-005 clinical trial in Japan. The trial involves a catheter-based administration of allogeneic iPS cell-derived cardiomyocyte spheroids, and the company aims to submit the clinical trial application by the end of 2025, with no changes to their financial forecast.

The most recent analyst rating on (JP:219A) stock is a Hold with a Yen3791.00 price target. To see the full list of analyst forecasts on Heartseed, Inc. stock, see the JP:219A Stock Forecast page.

Heartseed Inc. Reports Strong Financial Recovery
Sep 11, 2025

Heartseed Inc. reported significant financial improvements for the nine months ending July 31, 2025, with net sales reaching ¥1,919 million compared to ¥153 million in the previous year. This positive shift indicates a strong recovery and growth trajectory, enhancing the company’s market position and potentially benefiting its stakeholders.

The most recent analyst rating on (JP:219A) stock is a Hold with a Yen3791.00 price target. To see the full list of analyst forecasts on Heartseed, Inc. stock, see the JP:219A Stock Forecast page.

Heartseed Inc. Revises 2025 Financial Forecast Upward
Aug 14, 2025

Heartseed Inc. has revised its full-year financial forecast for 2025, significantly increasing its net sales and profit expectations due to achieving a development milestone earlier than anticipated under its agreement with Novo Nordisk A/S. This milestone achievement has resulted in additional revenues, and the company also anticipates lower-than-expected expenses related to clinical trials and cell manufacturing, enhancing its financial outlook.

Heartseed Inc. Stock Gains Loan Margin Trading Status
Aug 13, 2025

Heartseed Inc. announced that its stock has been newly selected as a Loan Margin Trading Issue on the Tokyo Stock Exchange Growth Market, effective August 14, 2025. This selection is expected to enhance the liquidity and trading activity of the company’s stock, potentially leading to fairer pricing and a better supply-demand balance.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 30, 2025