TipRanks
Go Ultimate55% OFF

Innate Pharma (IPHA) AI Stock Analysis

IPHA

Innate Pharma

(NASDAQ:IPHA)

Select Model
Rating:51Neutral
Price Target:$1.50▲(6.38% Upside)
Action:reiterated
Date:09/22/26

The score is held back primarily by weak financial performance—sharp revenue contraction, ongoing heavy losses and cash burn, and negative shareholders’ equity. The latest earnings call meaningfully offsets this with positive guidance, multiple upcoming clinical catalysts, and an extended cash runway into Q1 2028. Technical signals remain soft (negative MACD and below key moving averages), while valuation is difficult to assess with a negative P/E and no dividend support.

Positive Factors
Strategic partnerships and royalty potentialThe Sobi partnership provides non-dilutive upfront funding, milestone potential and future royalty economics while transferring key development responsibilities. Lacutamab’s regulatory designations and planned Phase 3 program could support a durable commercial pathway if clinical results validate the asset.
Negative Factors
Sharp revenue contraction and persistent lossesThe sharp revenue decline and continuing large losses show that Innate has not yet established a stable commercial earnings base. Costs remain well above the current revenue run-rate, limiting internal funding capacity and making financial performance highly dependent on pipeline progress.

Innate Pharma (IPHA) vs. SPDR S&P 500 ETF (SPY)

-40%-20%0%20%40%60%IPHA-22.22%SPY+12.20%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
$150.35M
Dividend Yield
―
Average Volume (3M)
159.15K
Price to Earnings (P/E)
-2.4
Beta (1Y)
0.69
Revenue Growth
-24.21%
EPS Growth
1.17%
Country
US
Employees
163
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Innate Pharma Business Overview & Revenue Model

Company Description

Innate Pharma S.A. is a biotechnology firm, founded in 1999 and headquartered in Marseille, France, that specializes in the discovery, development, and market introduction of therapeutic antibodies. The company primarily targets oncology indications...

Innate Pharma Earnings Call Summary

Earnings Call Date:Sep 16, 2026(Q2-2026)|% Change Since:-29.85%|Next Earnings Date:Mar 24, 2027
Earnings Call SentimentPositive

The call conveyed a strongly positive outlook, with the lacutamab partnership closing, Phase 3 initiation, preliminary IPH4.5 thousand objective responses and favorable safety observations, completed monalizumab enrollment, multiple upcoming catalysts, and a cash runway expected through the end of the first quarter of 2028. The main qualifications were that IPH4.5 thousand data remain early, the post-enfortumab vedotin urothelial cancer setting lacks an established second-line standard, and broader development could require additional funding.

Positive Updates

Lacutamab Partnership Closed and Phase 3 Initiated
The strategic partnership with Sobi to advance lacutamab in T-cell lymphoma has closed and become effective. The TELLOMAK-3 confirmatory Phase 3 study has been initiated, with the first patient expected in the first quarter of 2027.

Negative Updates

Early-Stage Status of IPH4.5 thousand Data
The company emphasized that the observed activity in IPH4.5 thousand consists of early Phase 1 observations. Data cleaning is ongoing, and the upcoming dataset is needed to determine how best to advance the program.

Company Guidance

Innate is targeting the first patient in TELLOMAK-3 in Q1 2027, with the first patient expected in the first quarter of 2027 and a filing for accelerated approval in Sezary Syndrome currently planned for the second half of 2027; initial Phase 1 dose escalation data for IPH4.5 thousand are expected on November 18, 2026, with approximately 15 patients enrolled in both post TB urothelial cancer, head and neck cancer, and somewhat lower enrollment in the non-small cell lung cancer cohort; the PACIFIC-9 Phase 3 readout remains expected in the second half of 2026, with a press release from AstraZeneca and Innate also looking to press release that as well and potentially do some calls; the $75 million Sobi upfront payment and €30 million equity offering, representing €28 million in expected net proceeds, are expected to extend cash runway through the end of the first quarter of 2028; lacutamab pricing research established a range of $500 thousand to $650 thousand per patient per annum; and the €30 million raise funds the initial steps into dose optimization, while broadening the program across additional tumor types would require additional funding.

Innate Pharma Financial Statement Overview

Summary

Weak fundamentals driven by sharply lower 2025 revenue (~48% YoY), sustained large operating losses and deeply negative margins, and persistent negative operating/free cash flow (notably ~-$50.7M operating cash flow in 2025). A major risk is shareholders’ equity turning negative in 2025, signaling elevated solvency/dilution pressure despite some debt reduction and modest year-over-year improvement in free cash flow.

Income Statement

18Very Negative

Balance Sheet

22Negative

Cash Flow

17Very Negative
Financial statement breakdown
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue1.08M2.79M12.62M51.90M57.67M12.11M
Gross Profit18.45M2.79M12.62M5.62M6.01M-22.30M
EBITDA-51.94M-43.65M-46.91M-1.84M-12.28M-43.23M
Net Income-47.51M-49.18M-49.47M-7.57M-58.10M-52.81M
Balance Sheet
Total Assets34.71M62.69M111.06M175.19M207.86M267.50M
Cash, Cash Equivalents and Short-Term Investments10.89M34.30M80.77M92.46M101.48M119.84M
Total Debt20.20M22.56M31.00M39.89M42.25M44.25M
Total Liabilities75.20M84.39M102.22M132.29M153.71M160.06M
Stockholders Equity-40.49M-21.69M8.83M51.90M54.15M107.44M
Cash Flow
Free Cash Flow-44.90M-34.91M-7.29M-34.91M-20.28M-59.79M
Operating Cash Flow-44.72M-32.56M-6.90M-32.56M-19.15M-58.46M
Investing Cash Flow2.81M20.63M9.20M20.63M1.88M-917.00K
Financing Cash Flow-6.11M-1.97M-6.01M-1.97M-1.83M26.82M

Innate Pharma Technical Analysis

Technical Analysis SentimentNegative
Last Price1.41

Price Trends

50DMA1.75Negative
100DMA1.81Negative
200DMA1.71Negative

Market Momentum

MACD-0.07Negative
RSI36.70Neutral
STOCH27.59Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For IPHA, the sentiment is Negative. The current price of 1.41 is below the 20-day moving average (MA) of 1.50, below the 50-day MA of 1.75, and below the 200-day MA of 1.71, indicating a bearish trend. The MACD of -0.07 indicates Negative momentum. The RSI at 36.70 is Neutral, neither overbought nor oversold. The STOCH value of 27.59 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for IPHA.

Innate Pharma Risk Analysis

Innate Pharma disclosed 89 risk factors in its most recent earnings report. Innate Pharma reported the most risks in the "Tech & Innovation" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Tech & Innovation - Risks related to the company’s reliance on technology and ability to make innovative products

Latest Risks Added

1 New Risk
1.The Company relies on certain independent organizations, partners, advisors and consultants to provide certain services and needs to hire new employees and expand its use of service providers.Q4, 2023

Innate Pharma Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

IPHA against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
IPHAIPHA51Neutral$156.91M-2.39152.56%―-24.21%1.17%
VORVOR50Neutral$1.16B0.06-830.38%―――
SLSSLS45Neutral$1.95B-40.46-35.91%――35.38%
ELTXELTX42Neutral$45.51M-0.75-1266.43%――49.43%

* Healthcare Sector Average

Performance Comparison

0%200%400%600%800%IPHASLSELTXVORDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
IPHA and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
IPHAInnate Pharma SA Sponsored ADR1.40-0.42-23.08%
SLSSellas Life Sciences Group8.556.87408.93%
ELTXElicio Therapeutics, Inc1.59-7.54-82.58%
VORVor Biopharma, Inc.19.25-1.66-7.94%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Sep 22, 2026