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Werewolf Therapeutics (HOWL)
NASDAQ:HOWL
US Market
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Werewolf Therapeutics (HOWL) AI Stock Analysis

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HOWL

Werewolf Therapeutics

(NASDAQ:HOWL)

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Neutral 41 (OpenAI - 4o)
Rating:41Neutral
Price Target:
$1.00
▼(-17.36% Downside)
The overall stock score of 40.6 reflects significant financial challenges, including ongoing losses and negative cash flows, which are typical for early-stage biotechnology firms. The technical analysis indicates a bearish trend with the stock trading below key moving averages and approaching oversold conditions. The valuation score is low due to negative profitability and lack of dividend yield, highlighting the company's focus on growth over income distribution.
Positive Factors
Regulatory Advancement
The Fast Track Designation for WTX-124 can accelerate the development process, potentially leading to earlier market entry and revenue generation, addressing unmet medical needs in cancer treatment.
Proprietary Platform
The proprietary platform enhances drug efficacy and minimizes side effects, providing a competitive edge in developing innovative cancer therapies, which is crucial for long-term success in biotechnology.
Partnership Revenue Model
The partnership and licensing model provides diversified revenue streams, reducing dependency on single product success and enhancing financial stability through collaborative development efforts.
Negative Factors
Negative Cash Flow
Persistent negative cash flow highlights challenges in sustaining operations without external financing, which can limit growth and increase financial risk over time.
Inconsistent Revenue Growth
Inconsistent revenue growth undermines financial predictability and can hinder strategic planning and investment, posing risks to long-term business stability and expansion.
Declining Equity
A declining equity ratio suggests weakening financial health, limiting the company's ability to leverage assets for growth and increasing vulnerability to market fluctuations.

Werewolf Therapeutics (HOWL) vs. SPDR S&P 500 ETF (SPY)

Werewolf Therapeutics Business Overview & Revenue Model

Company DescriptionWerewolf Therapeutics (HOWL) is a biotechnology company focused on developing innovative therapies for cancer and other serious diseases. The company specializes in a proprietary platform that combines targeted therapeutics with its unique drug delivery systems to enhance the efficacy of treatments while minimizing side effects. With a strong emphasis on research and development, Werewolf Therapeutics aims to address unmet medical needs through its advanced therapeutic solutions.
How the Company Makes MoneyWerewolf Therapeutics generates revenue primarily through a combination of product development partnerships, licensing agreements, and potential future sales of its proprietary therapeutics. The company collaborates with pharmaceutical companies and research institutions to co-develop new therapies, which may involve upfront payments, milestone payments based on development progress, and royalties from future sales. Additionally, the company may pursue grants and funding from governmental and non-governmental organizations aimed at supporting innovative biotech solutions, further contributing to its revenue streams.

Werewolf Therapeutics Financial Statement Overview

Summary
Werewolf Therapeutics faces significant financial challenges typical of a biotechnology firm in early stages, with ongoing operating losses and negative cash flows. The reliance on financing suggests potential liquidity risks, while inconsistent revenue growth and declining equity pose challenges for future stability and expansion.
Income Statement
35
Negative
Werewolf Therapeutics has shown inconsistent revenue figures over the years with a recent drop from 2023 to 2024. Gross profit margins are highly volatile, and the company has been operating with negative net profit margins consistently, indicating ongoing losses. EBIT and EBITDA margins are negative, reflecting operating inefficiencies and high operational costs relative to revenue.
Balance Sheet
40
Negative
The company has a moderate debt-to-equity ratio, which has improved over time due to a reduction in total debt. However, the equity ratio has been declining, indicating a decrease in equity relative to assets. Return on equity is negative, as losses have been persistent. The financial stability is moderate with a reasonable cash position compared to liabilities, yet the trend is concerning with shrinking equity.
Cash Flow
30
Negative
Operating cash flows have been negative, indicating cash burn, and free cash flows have also been consistently negative, showing challenges in generating cash from operations. Financing cash flows have been positive, suggesting reliance on external financing to support operations. The ratios of cash flows to net income highlight issues in converting revenue into cash.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue-49.00K1.89M19.94M16.40M0.000.00
Gross Profit-1.80M71.00K18.18M13.89M-735.00K-777.00K
EBITDA-51.37M-64.05M-32.47M-51.30M-49.25M-14.26M
Net Income-72.84M-70.52M-37.37M-53.81M-49.77M-14.94M
Balance Sheet
Total Assets79.63M126.93M174.83M160.25M179.25M96.40M
Cash, Cash Equivalents and Short-Term Investments66.61M111.00M134.34M129.31M157.53M92.57M
Total Debt9.64M37.09M51.92M14.68M15.66M2.54M
Total Liabilities50.01M53.54M63.46M37.91M26.46M148.26M
Stockholders Equity29.61M73.39M111.37M122.34M152.79M-51.86M
Cash Flow
Free Cash Flow-63.64M-56.44M-33.38M-44.21M-43.37M-19.18M
Operating Cash Flow-63.52M-56.19M-32.61M-40.60M-42.88M-18.62M
Investing Cash Flow-123.00K-254.00K-769.00K-3.61M-498.00K-560.00K
Financing Cash Flow6.21M13.08M58.43M15.91M109.43M93.86M

Werewolf Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.21
Price Trends
50DMA
1.61
Negative
100DMA
1.42
Negative
200DMA
1.28
Negative
Market Momentum
MACD
-0.10
Positive
RSI
30.75
Neutral
STOCH
26.22
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For HOWL, the sentiment is Negative. The current price of 1.21 is below the 20-day moving average (MA) of 1.59, below the 50-day MA of 1.61, and below the 200-day MA of 1.28, indicating a bearish trend. The MACD of -0.10 indicates Positive momentum. The RSI at 30.75 is Neutral, neither overbought nor oversold. The STOCH value of 26.22 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for HOWL.

Werewolf Therapeutics Risk Analysis

Werewolf Therapeutics disclosed 86 risk factors in its most recent earnings report. Werewolf Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Werewolf Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
52
Neutral
$64.95M-2.69-54.21%-19.44%-492.39%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
45
Neutral
$65.13M-1.2218.51%
41
Neutral
$55.33M-0.74-100.55%-100.00%-22.09%
28
Underperform
$78.83M-0.62-50.68%73.18%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
HOWL
Werewolf Therapeutics
1.21
-1.23
-50.41%
CRVO
CervoMed
7.02
-5.82
-45.33%
NRXP
NRX Pharmaceuticals
2.74
1.43
109.16%
KLRS
Kalaris Therapeutics
4.71
-18.52
-79.72%
COEP
Coeptis Therapeutics Holdings
14.75
10.59
254.57%
CAMP
CAMP4 Therapeutics Corporation
3.77
-5.33
-58.57%

Werewolf Therapeutics Corporate Events

Werewolf Therapeutics Reports Q3 2025 Financial Results
Nov 5, 2025

Werewolf Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative therapeutics to stimulate the immune system for cancer treatment, operating primarily in the biotechnology sector.

Werewolf Therapeutics’ WTX-330 Study: A Potential Game-Changer in Oncology
Oct 27, 2025

Werewolf Therapeutics, Inc. is conducting a clinical study titled A Phase 1b/2 Multisite Dose- and Regimen-finding and Expansion Study of WTX-330 in Adult Patients With Selected Advanced or Metastatic Solid Tumors or Non-Hodgkin Lymphoma. The study aims to evaluate the safety, tolerability, and antitumor activity of WTX-330, a novel drug, in adult patients with advanced solid tumors or lymphoma. Key objectives include determining the maximum tolerated dose and assessing the drug’s impact on overall survival and immunological biomarkers.

Werewolf Therapeutics’ Promising Study on WTX-124 in Cancer Treatment
Oct 27, 2025

Werewolf Therapeutics, Inc. (HOWL) is conducting a Phase I/Ib clinical study titled A Multicenter Phase I/Ib Dose Escalation and Expansion Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab in Patients With Selected Advanced or Metastatic Solid Tumors. The study aims to evaluate the safety and efficacy of WTX-124, both alone and in combination with pembrolizumab, in treating advanced or metastatic solid tumors. This research is significant as it explores new treatment avenues for challenging cancer types.

Executive/Board ChangesRegulatory Filings and Compliance
Werewolf Therapeutics Faces Nasdaq Compliance Challenge
Neutral
Oct 6, 2025

Werewolf Therapeutics announced the passing of Dr. Alon Lazarus, a Board member, on September 30, 2025. His death left the company’s Audit Committee noncompliant with Nasdaq’s listing rules, prompting the company to plan for appointing a new independent director to regain compliance.

The most recent analyst rating on (HOWL) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on Werewolf Therapeutics stock, see the HOWL Stock Forecast page.

Werewolf Therapeutics Faces Regulatory and Financial Challenges Amid FDA Disruptions
Aug 15, 2025

Werewolf Therapeutics, Inc. faces significant business risks due to potential disruptions at the FDA and other government agencies stemming from funding cuts, personnel losses, and regulatory reforms. The recent reduction in force and budget cuts at the FDA, along with executive orders from the Trump administration, could delay the guidance and approval processes critical for the company’s clinical development programs. Such disruptions may hinder the timely development and approval of Werewolf’s product candidates, negatively impacting their business operations. Additionally, government shutdowns and public health emergencies could further exacerbate these challenges, affecting the company’s ability to secure necessary capital and continue its operations.

Werewolf Therapeutics Reports Q2 2025 Financial Results
Aug 15, 2025

Werewolf Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative therapeutics that stimulate the immune system to treat cancer and other immune-mediated conditions, operating primarily in the biotechnology sector. In its latest earnings report for the quarter ending June 30, 2025, Werewolf Therapeutics highlighted its ongoing efforts in research and development, despite facing significant financial challenges. The company reported a net loss of $17.98 million for the quarter, with total operating expenses amounting to $17.54 million, primarily driven by research and development costs. Werewolf Therapeutics ended the quarter with $77.6 million in cash and cash equivalents, a decrease from $110.99 million at the end of 2024, indicating a need for additional funding to continue its operations and development programs. Looking ahead, Werewolf Therapeutics remains committed to advancing its product candidates through clinical trials and exploring strategic partnerships to support its financial needs, while navigating the competitive landscape of the biotechnology industry.

Business Operations and StrategyFinancial Disclosures
Werewolf Therapeutics Reports Q2 2025 Financial Results
Neutral
Aug 14, 2025

Werewolf Therapeutics reported its second-quarter 2025 financial results and provided a business update, highlighting progress in their clinical trials and product development. The company is on track for an interim data readout of its WTX-124 Phase 1/1b trial in late 2025, targeting melanoma and renal cell carcinoma. They also plan to engage with the FDA regarding potential pathways for WTX-124. Additionally, Werewolf introduced WTX-1011, a new T-cell engager candidate for prostate cancer, and announced plans to nominate another candidate by year-end. Financially, the company reported a net loss of $18 million for the quarter, with sufficient cash to fund operations into late 2026.

The most recent analyst rating on (HOWL) stock is a Buy with a $12.00 price target. To see the full list of analyst forecasts on Werewolf Therapeutics stock, see the HOWL Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 05, 2025