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GlaxoSmithKline (GSK) AI Stock Analysis
GlaxoSmithKline
(LSE:GSK)
The score is driven primarily by solid financial quality (high margins, strong and growing free cash flow) and a constructive earnings outlook with reaffirmed guidance and broad pipeline/launch momentum. Offsetting these positives are a still-levered balance sheet and a mixed technical backdrop (below key longer-term moving averages), while valuation and dividend provide moderate support.
GlaxoSmithKline (GSK) vs. iShares MSCI United Kingdom ETF (EWC)
- Market Cap
- GBP 74.33B
- Dividend Yield
- 3.67%
- Average Volume (3M)
- 6.53M
- Price to Earnings (P/E)
- 17.2
- Beta (1Y)
- 1.16
- Revenue Growth
- 4.28%
- EPS Growth
- -19.93%
- Country
- UK
- Employees
- 66,841
- Sector
- Healthcare
- Sector Strength
- 51
- Industry
- Drug Manufacturers - General
GlaxoSmithKline Business Overview & Revenue Model
Company Description
GSK plc is a global pharmaceutical and healthcare company, deeply involved in the research, development, production, and commercialization of a diverse range of medicinal and wellness products. Its operations span the United Kingdom, the United State...
How the Company Makes Money
GSK makes money primarily by selling branded prescription medicines and vaccines to healthcare systems, wholesalers/distributors, pharmacies, hospitals, and government/public-health customers worldwide. Its key revenue streams include: (1) Prescripti...
GlaxoSmithKline Earnings Call Summary
The call was strongly positive overall. GSK reported solid Q3 sales, operating profit, specialty-medicine growth, cash generation, launch progress, and a significant acceleration in phase III development. The company also reaffirmed 2026 guidance and highlighted encouraging clinical and commercial momentum across oncology, respiratory, HIV, hepatitis B, vaccines, and business development. The main negatives were higher restructuring charges, sharply increased R&D and interest costs, foreign-exchange headwinds, vaccine and inhaler-market pressure, Shingrix inventory and China destocking, and unresolved analysis around the four-monthly APRETUDE formulation. These challenges were meaningful but were outweighed by the breadth of the reported operational and pipeline progress.
Q3-2026 Updates
Positive Updates
Negative Updates
Company Guidance
GSK reconfirmed 2026 guidance: sales are expected in the upper half of the range, core operating profit is also expected in the upper half of the range, margin remains on track to be more than 31% at constant rates, SG&A is projected to be broadly stable, royalties are now upgraded to around GBP 900 million for the year, R&D is expected to grow significantly ahead of sales for the year, with 22 phase III starts versus 10 expected at the start of the year, EPS growth is expected to be in the low half of the range, full year interest is expected to be GBP 700 million-GBP 750 million, including around GBP 160 million relating to the acquisition of Nuvalent, and foreign exchange headwinds are expected to be -1% on sales and -3% on operating profit; the company remains on track to deliver around GBP 10 billion CGFO at constant rates and now expects charges of up to GBP 1 billion in 2026.
GlaxoSmithKline Financial Statement Overview
Summary
Fundamentals are solid but not flawless: modest TTM revenue growth (~2.4%) with strong sector profitability (gross margin ~73%, EBIT ~25%, net ~14%) and solid free cash flow (~6.8B) with strong TTM FCF growth (~18.8%). Offsets are meaningful leverage (debt-to-equity ~1.03; debt ~23.7B) and some earnings/cash-conversion variability (FCF ~72% of net income, down vs 2025).
Income Statement
78PositiveBalance Sheet
66PositiveCash Flow
72Positive| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 33.54B | 32.67B | 31.38B | 30.33B | 29.32B | 24.70B |
| Gross Profit | 24.66B | 23.70B | 21.90B | 21.25B | 19.46B | 16.34B |
| EBITDA | 10.64B | 11.88B | 6.67B | 9.14B | 8.63B | 6.45B |
| Net Income | 4.35B | 5.72B | 2.58B | 4.93B | 14.96B | 4.38B |
Balance Sheet | ||||||
| Total Assets | 71.70B | 61.12B | 59.46B | 59.01B | 60.15B | 79.10B |
| Cash, Cash Equivalents and Short-Term Investments | 2.96B | 3.16B | 3.71B | 5.69B | 7.68B | 4.13B |
| Total Debt | 23.70B | 17.72B | 16.99B | 18.02B | 20.99B | 24.17B |
| Total Liabilities | 53.34B | 45.16B | 46.38B | 46.21B | 50.05B | 57.76B |
| Stockholders Equity | 18.75B | 16.38B | 13.67B | 13.35B | 10.60B | 15.05B |
Cash Flow | ||||||
| Free Cash Flow | 6.84B | 5.96B | 3.57B | 4.42B | 5.14B | 5.02B |
| Operating Cash Flow | 8.56B | 7.30B | 6.55B | 6.77B | 7.40B | 7.95B |
| Investing Cash Flow | -12.55B | -5.85B | -1.23B | -1.59B | -8.77B | -1.78B |
| Financing Cash Flow | 3.95B | -1.63B | -4.73B | -5.64B | 823.00M | -7.59B |
GlaxoSmithKline Technical Analysis
Price Trends
Market Momentum
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:GSK, the sentiment is Negative. The current price of 1830.50 is above the 20-day moving average (MA) of 1830.50, below the 50-day MA of 1845.28, and below the 200-day MA of 1929.48, indicating a neutral trend. The MACD of 8.50 indicates Negative momentum. The RSI at 50.94 is Neutral, neither overbought nor oversold. The STOCH value of 35.09 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for GB:GSK.
GlaxoSmithKline Risk Analysis
GlaxoSmithKline disclosed 1 risk factors in its most recent earnings report. GlaxoSmithKline reported the most risks in the "Legal & Regulatory" category.
Latest Risks Added
1 New RiskGlaxoSmithKline Peers Comparison
Overall Rating
GB:AZN80.1Outperform
GB:HIK74Outperform
GB:SN72Outperform
GB:GSK69Neutral
GB:HLN63Neutral
Financial Indicators
| Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
| 80Outperform | GBP 216.51B | 26.27 | 22.31% | 1.71% | 4.55% | 14.19% | |
| 74Outperform | GBP 3.58B | 12.95 | 15.05% | 3.66% | 2.48% | 3.36% | |
| 72Outperform | GBP 9.27B | 19.52 | 12.25% | 2.66% | 2.17% | 27.33% | |
| 69Neutral | GBP 74.37B | 17.18 | 24.64% | 3.67% | 4.28% | -19.93% | |
| 63Neutral | GBP 28.09B | 17.61 | 9.89% | 2.29% | 1.21% | 8.33% | |
| Sector * | 51Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% |
* Healthcare Sector Average
Performance Comparison
| Show on chart | Ticker | Company Name | Price | Change | % Change |
|---|---|---|---|---|---|
| GB:GSK | GlaxoSmithKline plc (UK) | 1855.00 | 127.00 | 7.35% | |
| GB:AZN | AstraZeneca plc | 13960.00 | 1642.47 | 13.33% | |
| GB:HIK | Hikma Pharmaceuticals | 1731.00 | 46.57 | 2.76% | |
| GB:SN | Smith & Nephew (UK) | 1107.50 | -272.82 | -19.76% | |
| GB:BXP | Beximco Pharmaceuticals Limited Sponsored GDR RegS | 54.00 | 12.92 | 31.44% | |
| GB:HLN | Haleon PLC | 319.40 | -31.39 | -8.95% |
GlaxoSmithKline Corporate Events
GSK Wins Landmark U.S. Approval for First‑in‑Class Hepatitis B Cure Therapy
PositiveGSK has won U.S. FDA approval for Hibsago (bepirovirsen), a first‑in‑class antisense oligonucleotide for adults with chronic hepatitis B virus infection on stable nucleos(t)ide analogue therapy and without cirrhosis, marking a major advan...
GSK’s Jemperli Wins Landmark FDA Nod for Biomarker-Defined Rectal Cancer
PositiveGSK has secured U.S. FDA accelerated approval for its PD-1 inhibitor Jemperli as the first and only immunotherapy for adults with stage II and III MSI-H/dMMR locally advanced rectal cancer, a biomarker-defined subset representing around five to ten p...
GSK’s Ris-Rez Shows Strong Global Response in Relapsed Small Cell Lung Cancer
PositiveGSK has unveiled the first global clinical data for risvutatug rezetecan (Ris-Rez), a B7-H3-targeted antibody-drug conjugate, in relapsed extensive-stage small cell lung cancer, reporting a 61% objective response rate at the selected 8 mg/kg dose and...
GSK Executives Reinvest Dividends in U.S.-Listed ADS
PositiveGSK plc has disclosed that three senior executives acquired American Depositary Shares through automatic dividend reinvestment following the company’s October 8, 2026 shareholder dividend. The purchases, executed on October 13 on the New York S...
GSK executives report dividend-driven increases in deferred share interests
NeutralGSK has disclosed a series of routine transactions involving several senior executives, including the chief executive and chief financial officer, relating to ordinary shares and American depositary shares. The changes stem from the automatic reinves...
GSK Executives Increase Holdings Through Dividend Reinvestment
PositiveGSK has disclosed multiple transactions by senior management involving the automatic acquisition of ordinary shares via dividend reinvestment. Chief executive officer Luke Miels, Europe president Lynn Baxter, International president Mike Crichton and...
GSK Executives Reinvest Dividends in Routine Share Acquisitions
NeutralGSK plc has disclosed a series of share transactions involving several senior executives, including Chief Executive Officer Luke Miels and regional and functional presidents. The transactions consist of small acquisitions of ordinary shares on the Lo...
GSK Director Wendy Becker Joins Tesco Board as Non-Executive
NeutralGSK has disclosed that independent non-executive director Wendy Becker has been appointed as a non-executive director of Tesco, effective 1 November 2026, in line with UK listing requirements for such announcements. The appointment underscores the cr...
GSK Adds Shares Under Employee Plan to London Listing
NeutralGSK has admitted 19,352 new ordinary shares of 31¼ pence each to trading on the London Stock Exchange’s Main Market, bringing the total number of ordinary shares in issue to 4,316,311,662. The newly admitted shares, issued under the GlaxoS...
GSK Updates Market on Total Voting Rights and Share Capital
NeutralGSK plc has reported its latest share capital structure in line with UK Financial Conduct Authority transparency rules, confirming an issued share capital of 4,316,311,549 ordinary shares as of 30 September 2026. Of this total, 270,881,064 shares are...
GSK Discloses Executive Notional ADS Acquisition Under Savings Plan
NeutralGSK plc disclosed a transaction involving a person discharging managerial responsibilities, reflecting ongoing adherence to market transparency rules. The filing reports that Maya Martinez-Davis, President U.S., acquired a small number of notional Am...
GSK directors boost holdings with coordinated share purchases
PositiveSeveral GSK board members have purchased company securities, signalling additional personal investment in the biopharmaceutical group. Non-Executive Chair Sir Jonathan Symonds bought 1,500 ordinary shares on the London Stock Exchange on 18 September...
GSK Deepens Blood Cancer Push With $750 Million Trispecific TCE Deal
PositiveGSK has agreed to acquire a trispecific T cell-engager from Chimagen Biosciences for development in multiple myeloma, aiming to bring the programme into phase I trials in 2027 and secure full global rights under a deal worth up to $750 million. The d...
GSK’s Ris-Rez delivers landmark survival gains in relapsed small cell lung cancer
PositiveGSK and its licensor Hansoh Pharmaceutical reported phase III data from the ARTEMIS-008 trial in China showing that B7-H3-targeted antibody-drug conjugate risvutatug rezetecan (Ris-Rez) cut the risk of death by 54% versus topotecan in relapsed small...
GSK’s Jideytro delivers strong first-line results in ROS1-positive lung cancer trial
PositiveGSK reported positive phase I/II data from its ARROS-1 trial of Jideytro (zidesamtinib) in tyrosine kinase inhibitor-naïve patients with advanced or metastatic ROS1-positive non-small cell lung cancer. The company plans a U.S. regulatory filing...
GSK Executives Acquire Shares Under Company Reward Plan
PositiveGSK plc has disclosed a series of small share acquisitions by several senior executives under its Share Reward Plan, reflecting routine participation in an established employee share ownership scheme. The transactions involve ordinary shares listed o...
GSK Reports Executive Acquisition of Notional ADS in Savings Plan
NeutralGSK disclosed that Maya Martinez-Davis, the company’s President, US, has acquired notional American Depositary Shares in her GSK Executive Supplemental Savings Plan. The transaction, executed on 8 September 2026 on the New York Stock Exchange,...
GSK Grants Performance-Based Share Award to Chief People Officer
NeutralGSK has granted a conditional share award to Chief People Officer and Executive Committee member Roanne Parry under its 2017 Performance Share Plan. The award, over 85,714 ordinary shares, forms part of the company’s performance-related incenti...
GSK awards share-based incentives to senior leadership under 2025 plan
NeutralGSK has disclosed awards of ordinary shares to two senior figures under its 2025 Share Value Plan, reinforcing equity-based incentives at the top of the organisation. SVP and Company Secretary Victoria Whyte received 10,050 ordinary shares at £1...
GSK Updates Market on Total Voting Rights and Share Capital
NeutralGSK has updated the market on its capital structure, reporting that as of 31 August 2026 its issued share capital comprised 4,316,302,379 ordinary shares, including 270,881,064 shares held in treasury. After accounting for treasury shares, the total...
GSK advances mRNA flu vaccine to phase III after strong mid-stage data
PositiveGSK reported positive phase II results for its investigational mRNA-based seasonal influenza vaccine, which targets both haemagglutinin and neuraminidase surface antigens of the virus. The candidate generated higher immune responses than standard-dos...
GSK Reports Executive Acquisition of Notional ADS in Supplemental Savings Plan
NeutralGSK disclosed that Maya Martinez-Davis, its President, US, acquired notional American Depositary Shares through her GSK Executive Supplemental Savings Plan account. The transaction, involving a small volume of ADSs at a price of $51.78 per share, was...
GSK US President Sells Over 44,000 American Depositary Shares
NegativeGSK disclosed that Maya Martinez-Davis, its US president and a person discharging managerial responsibilities, sold a total of 3,916 American Depositary Shares on 20 August 2026 at an aggregate price of $52.14 per ADS on the New York Stock Exchange....
GSK wins first global approval for hepatitis B functional cure in Japan
PositiveJapan’s Ministry of Health, Labour and Welfare has granted the first global approval for GSK’s Hibsago (bepirovirsen), an antisense oligonucleotide and the first functional cure for chronic hepatitis B in Japan. The drug is indicated for...
GSK’s Jemperli wins FDA priority review for advanced rectal cancer
PositiveGSK said the US Food and Drug Administration has accepted a priority review of its supplemental biologics application for Jemperli in previously untreated stage II and III mismatch repair deficient or microsatellite instability-high locally advanced...
GSK Executives Add ADS Through Dividend Reinvestment Plans
PositiveGSK disclosed several routine share transactions by senior executives involving the acquisition of American Depositary Shares through dividend reinvestment in company savings and supplemental plans. Non‑Executive Director Hal Barron, SVP and Gr...
GSK Executives Acquire Shares Under Company Reward Plan
PositiveGSK has disclosed a series of routine share dealings by several senior executives, including its CFO, regional presidents and other top managers, who each acquired 14 ordinary shares under the company’s Share Reward Plan. The purchases, all exe...
GSK Discloses Executive Notional ADS Acquisition by U.S. President
NeutralGSK plc disclosed a transaction involving Maya Martinez-Davis, its President for the U.S. business, who acquired notional American Depositary Shares through her GSK Executive Supplemental Savings Plan. The purchase, executed on 7 August 2026 on the N...
GSK Updates Market on Total Voting Rights and Share Capital
NeutralGSK has reported that as of 31 July 2026 its issued share capital comprised more than 4.3 billion ordinary shares, of which around 271 million are held in treasury, resulting in a total of 4.045 billion voting rights. The disclosure, made under UK Fi...
GSK Supply Chain President Registers Sale of Ordinary Shares
NeutralGSK disclosed that Regis Simard, the company’s President of Global Supply Chain, has sold 38,000 ordinary shares in the group. The transaction, executed on July 29, 2026 on the London Stock Exchange at £20.38 per share, reflects routine de...
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.
Date of analysis: Oct 29, 2026