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Equillium (EQ) AI Stock Analysis

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EQ

Equillium

(NASDAQ:EQ)

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Rating:48Neutral
Price Target:$1.50â–²(5.63% Upside)
Action:reiterated
Date:10/27/26

The score is held back primarily by weak financial performance (zero TTM revenue, ongoing losses, and sustained cash burn) and bearish technicals (price below major moving averages with negative MACD). Offsetting these risks, recent corporate events strengthen the outlook by advancing the EQ504 program and extending the cash runway into 2029, while valuation remains hard to assess favorably due to negative earnings and no dividend support.

Positive Factors
Low LeverageVery low debt relative to equity gives Equillium a conservative capital structure and limits interest or refinancing pressure. This financial flexibility can help preserve resources for clinical development and reduce balance-sheet risk while the company remains pre-profit.
Negative Factors
No Current RevenueZero current revenue alongside a sizable net loss shows that Equillium has not yet established an operating revenue base. Until a product or partnership generates recurring income, financial performance will remain dependent on clinical progress and access to external funding.

Equillium (EQ) vs. SPDR S&P 500 ETF (SPY)

-50%0%50%100%150%200%250%EQ+36.54%SPY+14.28%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
$90.04M
Dividend Yield
―
Average Volume (3M)
531.91K
Price to Earnings (P/E)
-5.5
Beta (1Y)
-0.47
Revenue Growth
-100.00%
EPS Growth
64.23%
Country
US
Employees
14
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Equillium Business Overview & Revenue Model

Company Description

Equillium, Inc. is a clinical-stage biopharmaceutical company focused on developing and bringing to market products designed to address severe autoimmune and inflammatory (immuno-inflammatory) disorders where current treatment options are insufficien...

Equillium Financial Statement Overview

Summary

Overall financials are weak: TTM revenue fell to zero with continued sizeable net losses (~$18M) and heavy ongoing cash burn (FCF ~-$20M). The balance sheet is the main offsetting strength with very low leverage (~$0.6M debt vs ~$56M equity), but persistent losses can continue eroding equity over time.

Income Statement

18Very Negative

Balance Sheet

62Positive

Cash Flow

24Negative
Financial statement breakdown
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue0041.09M36.08M15.76M0
Gross Profit-47.00K-116.00K41.09M36.08M15.76M-72.00K
EBITDA-18.32M-22.28M-7.57M-12.14M-61.26M-37.91M
Net Income-18.01M-22.40M-8.07M-13.34M-62.43M-38.98M
Balance Sheet
Total Assets58.67M31.89M25.60M50.53M78.42M85.41M
Cash, Cash Equivalents and Short-Term Investments57.16M30.28M22.57M40.87M71.02M80.71M
Total Debt584.00K719.00K384.00K824.00K10.19M11.79M
Total Liabilities2.65M3.29M6.54M27.96M46.48M18.90M
Stockholders Equity56.02M28.60M19.06M22.57M31.94M66.50M
Cash Flow
Free Cash Flow-20.09M-22.79M-19.11M-21.83M-9.01M-32.14M
Operating Cash Flow-19.97M-22.75M-19.03M-21.78M-8.73M-32.08M
Investing Cash Flow-106.00K4.46M13.81M-4.76M18.68M27.41M
Financing Cash Flow65.74M30.43M164.00K-9.23M-1.22M31.06M

Equillium Technical Analysis

Technical Analysis SentimentNegative
Last Price1.42

Price Trends

50DMA1.63Negative
100DMA2.08Negative
200DMA2.09Negative

Market Momentum

MACD-0.03Negative
RSI47.60Neutral
STOCH58.33Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For EQ, the sentiment is Negative. The current price of 1.42 is above the 20-day moving average (MA) of 1.36, below the 50-day MA of 1.63, and below the 200-day MA of 2.09, indicating a neutral trend. The MACD of -0.03 indicates Negative momentum. The RSI at 47.60 is Neutral, neither overbought nor oversold. The STOCH value of 58.33 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for EQ.

Equillium Risk Analysis

Equillium disclosed 86 risk factors in its most recent earnings report. Equillium reported the most risks in the "Tech & Innovation" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Tech & Innovation - Risks related to the company’s reliance on technology and ability to make innovative products

Latest Risks Added

3 New Risks
1.Risk factors summaryQ2, 2026
2.Risks Related to Our Financial Position and Need for Additional CapitalQ2, 2026
3.Risks Related to our Business and to the Development and Regulatory Approval of our Product CandidatesQ2, 2026

Equillium Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

EQ against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
EQEQ48Neutral$92.26M-5.54-41.15%―-100.00%64.23%
NRXPNRXP46Neutral$103.01M-3.28168.68%――67.07%
HYFTHYFT45Neutral$49.00M-4.02-144.31%―-26.89%56.50%
STROSTRO42Neutral$168.63M-0.59185.30%―-56.25%30.97%
PRLDPRLD38Underperform$300.06M-4.78-75.35%―220.34%55.73%

* Healthcare Sector Average

Performance Comparison

0%100%200%300%EQNRXPSTROHYFTPRLDDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
EQ and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
EQEquillium1.420.5869.05%
NRXPNrx Pharmaceuticals, Inc.2.44-0.15-5.79%
STROSutro Biopharma10.260.9710.44%
HYFTMindwalk Holdings Corp.1.03-0.62-37.58%
PRLDPrelude Therapeutics, Inc.3.782.27150.33%

Equillium Corporate Events

Business Operations and StrategyPrivate Placements and FinancingProduct-Related Announcements

Equillium advances EQ504 trial and extends cash runway

Positive
Oct 26, 2026

On October 26, 2026, Equillium reported dosing the first subject in its Phase 1 clinical trial of EQ504 in Australia, a randomized, double-blind, placebo-controlled study in about 70 healthy volunteers evaluating safety, tolerability, pharmacokinetic...

Business Operations and StrategyProduct-Related Announcements

Equillium Advances EQ504 With Phase 1 Trial Clearance

Positive
Oct 5, 2026

On October 5, 2026, Equillium, Inc. announced that it had secured Human Research Ethics Committee approval and Therapeutic Goods Administration clearance in Australia for a Phase 1 clinical trial of its oral candidate EQ504, with first dosing of heal...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Oct 27, 2026