Avalo Therapeutics (AVTX) AI Stock Analysis

• Market Cap: $237.14M
• Dividend Yield: N/A
• Average Volume (3M): 446.62K
• Price to Earnings (P/E): ―
• Beta (1Y): 1.00
• Revenue Growth: -45.35%
• EPS Growth: 96.80%
• Country: US
• Employees: 23
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -1.92
• Shares Outstanding: 13,152,356
• 10 Day Avg. Volume: 439,045
• 30 Day Avg. Volume: 446,620
• PEG Ratio: 0.02
• Price to Book (P/B): 0.45
• Price to Sales (P/S): 136.95
• P/FCF Ratio: -1.23
• Enterprise Value/Market Cap: -0.24
• Enterprise Value/Revenue: -128.26
• Enterprise Value/Gross Profit: -60.56
• Enterprise Value/Ebitda: 0.92
• 1Y Price Target: $33.51
• Price Target Upside: 101.02% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 7

• Rating: 57 Neutral
• Price Target: $18.00 ▲(7.98% Upside)

Avalo Therapeutics' overall stock score is primarily impacted by its poor financial performance, which reflects significant operational and profitability challenges. Despite strong technical indicators suggesting bullish momentum, the negative valuation metrics due to ongoing losses weigh heavily on the stock's attractiveness.

Positive Factors

Leadership Expansion

The addition of experienced leaders can enhance strategic decision-making and operational efficiency, potentially driving long-term growth and innovation.

Debt Elimination

Eliminating debt improves financial stability and flexibility, allowing Avalo to invest more in R&D and strategic initiatives without the burden of interest payments.

Board Appointment

Adding a board member with industry experience can provide valuable insights and guidance, supporting Avalo's strategic direction and governance.

Negative Factors

Revenue Decline

Significant revenue decline indicates challenges in product commercialization and market penetration, which could hinder long-term growth prospects.

Negative Cash Flow

Persistent negative cash flow suggests operational inefficiencies and reliance on external financing, which may not be sustainable long-term.

Profitability Challenges

Ongoing profitability issues reflect operational challenges and may limit Avalo's ability to fund R&D and growth initiatives without external support.

Avalo Therapeutics Business Overview & Revenue Model

Company Description

Avalo Therapeutics, Inc., a clinical-stage precision medicine company, discovers, develops, and commercializes targeted therapeutics for patients with unmet clinical need in immunology, immuno-oncology, and rare genetic diseases. It develops AVTX-002, a fully human anti-LIGHT monoclonal antibody, which is under Phase II clinical trial for the treatment of non-eosinophilic asthma, as well as inflammatory bowel disease, including moderate to severe Crohn's disease, and ulcerative colitis; and Phase III clinical trial for the treatment of COVID-19 acute respiratory distress syndrome. The company also engages in developing AVTX-007, a fully human Anti-IL-18 monoclonal antibody that is under Phase I clinical trial for the treatment of still's disease, including adult-onset still's disease and systemic juvenile idiopathic arthritis. Its products for rare genetic diseases in Phase III clinical trials include AVTX-801, a D-galactose substrate replacement therapy for the treatment of phosphoglucomutase 1 deficiency (PGM1), also known as PGM1-CDG; and AVTX-803, a L-fucose substrate replacement therapy for the treatment of LADII, also known as SLC35C1-CDG. The company was formerly known as Cerecor Inc. and changed its name to Avalo Therapeutics, Inc. in August 2021. Avalo Therapeutics, Inc. was incorporated in 2011 and is headquartered in Rockville, Maryland.

How the Company Makes Money

Avalo Therapeutics generates revenue primarily through the development and commercialization of its therapeutic products. The company may earn income from product sales once its candidates receive regulatory approval and are launched in the market. Additionally, Avalo could engage in strategic partnerships or collaborations with larger pharmaceutical companies, which may provide upfront payments, milestone payments, and royalties on sales of partnered products. Government grants and research funding can also contribute to its revenue, especially during the early stages of product development. Overall, the company’s financial health is heavily dependent on the successful advancement of its drug candidates through clinical trials and subsequent market introduction.

Avalo Therapeutics Financial Statement Overview

Summary

Avalo Therapeutics faces significant financial challenges, with declining revenues, persistent losses, and negative cash flow. Despite improvements in equity and debt elimination, the company's inability to generate positive cash flow and profits suggests substantial financial instability.

Income Statement

Avalo Therapeutics has experienced a significant decline in revenue over the years, with the most recent annual revenue dropping to $441,000 from $1,924,000 the previous year. The company also shows negative gross profit and net income over multiple years, indicating ongoing operational challenges. Additionally, the net profit margin is consistently negative, reflecting broader profitability issues.

Balance Sheet

The company's balance sheet shows a high equity ratio, primarily due to the elimination of total debt in the most recent year. However, the return on equity remains negative due to ongoing net losses. The stockholders' equity has improved significantly from negative to positive over the past year, which is a positive sign, but the lack of revenue growth remains concerning.

Cash Flow

Avalo Therapeutics demonstrates negative free cash flow consistently, indicating cash flow challenges. The operating cash flow to net income ratio is also negative, highlighting inefficiencies in translating operational activities into cash flow. Although financing activities have supported operations in previous years, the sustainability of this approach is uncertain given ongoing losses.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	441.00K	441.00K	1.92M	18.05M	5.40M	6.70M
Gross Profit	934.00K	807.00K	640.00K	14.62M	3.91M	6.40M
EBITDA	-61.22M	-68.34M	-23.29M	-37.29M	-80.50M	-45.45M
Net Income	-46.22M	-35.13M	-31.54M	-41.66M	-84.35M	-64.38M
Balance Sheet
Total Assets	126.58M	150.73M	20.99M	33.37M	80.21M	43.76M
Cash, Cash Equivalents and Short-Term Investments	113.28M	134.55M	7.42M	13.17M	54.59M	18.92M
Total Debt	2.68M	568.00K	537.00K	19.42M	32.83M	426.35K
Total Liabilities	22.01M	17.70M	13.69M	44.28M	57.13M	19.19M
Stockholders Equity	104.57M	133.03M	7.30M	-10.91M	23.08M	24.56M
Cash Flow
Free Cash Flow	-47.42M	-49.06M	-30.84M	-26.85M	-71.00M	-40.60M
Operating Cash Flow	-47.42M	-49.06M	-30.68M	-26.75M	-70.89M	-40.54M
Investing Cash Flow	-70.86M	356.00K	-133.00K	-95.00K	-113.00K	11.13M
Financing Cash Flow	67.24M	175.85M	25.04M	-14.70M	106.76M	44.78M

Avalo Therapeutics Technical Analysis

• Technical Analysis Sentiment: Positive
• Last Price: 16.67
• 50DMA: Positive
• 100DMA: Positive
• 200DMA: Positive
• MACD: Positive
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AVTX, the sentiment is Positive. The current price of 16.67 is above the 20-day moving average (MA) of 16.02, above the 50-day MA of 13.11, and above the 200-day MA of 7.98, indicating a bullish trend. The MACD of 1.45 indicates Positive momentum. The RSI at 57.29 is Neutral, neither overbought nor oversold. The STOCH value of 53.42 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for AVTX.

Avalo Therapeutics Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
AVTX	―	$237.14M	―	-90.25%	―	-45.35%	96.80%
Sector *	―	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
CRBP	―	$148.90M	―	-49.00%	―	―	18.15%
GUTS	―	$183.75M	―	-379.75%	―	-85.71%	66.38%
MIST	―	$163.19M	―	-780.29%	―	―	20.13%
FBRX	―	$146.46M	-1.47	-73.46%	―	―	62.69%
ELTX	―	$158.48M	-2.32	-9999.00%	―	―	-4.60%

Avalo Therapeutics Corporate Events

Avalo Therapeutics Highlights AVTX-009 Potential in New Presentation

On October 10, 2025, Avalo Therapeutics released an updated investor presentation highlighting the potential of their lead compound, AVTX-009, in treating hidradenitis suppurativa (HS). The presentation emphasizes AVTX-009’s superior efficacy and longer dosing intervals compared to existing treatments, positioning it as a promising candidate in a market expected to grow significantly. The ongoing Phase 2 LOTUS trial is expected to yield topline data by mid-2026, which could impact Avalo’s market position and stakeholder interests positively.

The most recent analyst rating on (AVTX) stock is a Buy with a $35.00 price target. To see the full list of analyst forecasts on Avalo Therapeutics stock, see the AVTX Stock Forecast page.

Avalo Therapeutics Strengthens Leadership with Key Appointments

On October 1, 2025, Avalo Therapeutics announced the appointment of Taylor Boyd as Chief Business Officer and Ashley Ivanowicz as Senior Vice President of Human Resources. These appointments are part of Avalo’s strategic efforts to strengthen its leadership team as it advances its lead asset, AVTX-009, through clinical trials. Taylor Boyd brings extensive experience in biotech business development and corporate finance, while Ashley Ivanowicz offers nearly 20 years of HR expertise in the biotech and pharmaceutical sectors. The appointments are expected to enhance Avalo’s strategic direction and organizational growth, supporting the company’s mission to deliver meaningful therapies for patients.

The most recent analyst rating on (AVTX) stock is a Buy with a $35.00 price target. To see the full list of analyst forecasts on Avalo Therapeutics stock, see the AVTX Stock Forecast page.

Avalo Therapeutics Appoints Kevin Lind to Board

On September 16, 2025, Avalo Therapeutics announced the appointment of Kevin Lind to its Board of Directors, effective October 1, 2025. Lind, a seasoned biotechnology executive with over 20 years of experience, will join the Audit Committee and has a history of successful leadership in capital markets and strategic company development. His appointment follows the resignation of June Almenoff, M.D., Ph.D., who stepped down to pursue new opportunities, effective the same date. Almenoff’s resignation was not related to any company issues, and her contributions over the past four years were acknowledged by Avalo.

The most recent analyst rating on (AVTX) stock is a Buy with a $35.00 price target. To see the full list of analyst forecasts on Avalo Therapeutics stock, see the AVTX Stock Forecast page.

Avalo Therapeutics Reports Q2 2025 Financial Results

Avalo Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing IL-1β-based treatments for immune-mediated inflammatory diseases, with its lead asset AVTX-009 currently in a Phase 2 trial for hidradenitis suppurativa.