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Annovis Bio
(NYSE:ANVS)
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Rating:45Neutral
Price Target:
$2.00
▲(20.48% Upside)
Action:Reiterated
Date:08/17/26
Overall score is pressured primarily by weak financial performance (no revenue, heavy losses, accelerating cash burn and funding risk despite no debt). Technicals are neutral with modest short-term stabilization but a weaker longer-term trend, while valuation is constrained by a negative P/E and no dividend. Corporate events are mixed, balancing Phase 3 enrollment progress against dilution from equity financing.
Positive Factors
Pivotal Phase 3 execution
Completing enrollment in a large, pivotal study reduces execution uncertainty and establishes defined six- and 18-month readouts. This advances buntanetap toward potential regulatory submissions and creates a clearer development pathway.
Negative Factors
No commercial revenue
The absence of product revenue means the company has no demonstrated commercial engine to offset research and development spending. Financial performance therefore remains dependent on clinical progress and continued access to external capital.
Read all positive and negative factors
Positive Factors
Negative Factors
Pivotal Phase 3 execution
Completing enrollment in a large, pivotal study reduces execution uncertainty and establishes defined six- and 18-month readouts. This advances buntanetap toward potential regulatory submissions and creates a clearer development pathway.
Read all positive factors
Annovis Bio (ANVS) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$78.70M
Dividend YieldN/A
Average Volume (3M)843.51K
Price to Earnings (P/E)―
Beta (1Y)2.16
Revenue GrowthN/A
EPS Growth11.96%
CountryUS
Employees7
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-1.80
Shares Outstanding42,606,150
10 Day Avg. Volume708,821
30 Day Avg. Volume843,507
Financial Highlights & Ratios
PEG Ratio0.02
Price to Book (P/B)4.22
Price to Sales (P/S)0.00
P/FCF Ratio>-0.01
Enterprise Value/Market Cap<0.01
Enterprise Value/RevenueN/A
Enterprise Value/Gross ProfitN/A
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price Target
$8.00Price Target Upside381.93% Upside
Rating ConsensusModerate Buy
Number of Analyst Covering2
EPS Forecast (FY)-1.69
Revenue Forecast (FY)N/A
Annovis Bio Business Overview & Revenue Model
Company Description
Annovis Bio, Inc. is a clinical-stage biopharmaceutical company focused on pioneering treatments for neurodegenerative disorders. The firm's flagship drug, Buntanetap, an oral medication, has successfully advanced through Phase 2a clinical trials ...
How the Company Makes Money
As a clinical-stage biotechnology company, Annovis Bio does not have commercialized products and, therefore, does not generate recurring revenue from product sales. Publicly available information indicates its funding historically comes primarily ...
Annovis Bio Financial Statement Overview
Summary
Income Statement
6
Very Negative
Balance Sheet
24
Negative
Cash Flow
8
Very Negative
| Breakdown | TTM | Dec 2025 | Mar 2025 | Mar 2024 | Mar 2023 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Gross Profit | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| EBITDA | -49.08M | -28.85M | -22.74M | -56.20M | -25.33M | -14.50M |
| Net Income | -49.52M | -28.85M | -24.59M | -56.20M | -25.33M | -14.49M |
Balance Sheet | ||||||
| Total Assets | 22.04M | 21.08M | 13.93M | 10.21M | 36.02M | 46.00M |
| Cash, Cash Equivalents and Short-Term Investments | 18.73M | 19.53M | 10.55M | 5.75M | 28.38M | 45.69M |
| Total Debt | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Total Liabilities | 26.29M | 4.23M | 4.62M | 17.96M | 7.70M | 1.51M |
| Stockholders Equity | -4.25M | 16.85M | 9.31M | -7.75M | 28.32M | 44.49M |
Cash Flow | ||||||
| Free Cash Flow | -30.94B | -25.62B | -21.89B | -39.97M | -17.31M | -9.13M |
| Operating Cash Flow | -30.94B | -25.62B | -21.89B | -39.97M | -17.31M | -9.13M |
| Investing Cash Flow | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Financing Cash Flow | 44.94M | 34.60B | 26.69B | 17.34M | 4.61K | 46.74M |
Annovis Bio Technical Analysis
Negative
1.66
Price Trends
1.80
Negative
1.91
Negative
2.49
Negative
Market Momentum
<0.01
Negative
44.47
Neutral
26.95
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ANVS, the sentiment is Negative. The current price of 1.66 is below the 20-day moving average (MA) of 1.78, below the 50-day MA of 1.80, and below the 200-day MA of 2.49, indicating a bearish trend. The MACD of <0.01 indicates Negative momentum. The RSI at 44.47 is Neutral, neither overbought nor oversold. The STOCH value of 26.95 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for ANVS.
Annovis Bio Risk Analysis
Annovis Bio disclosed 77 risk factors in its most recent earnings report. Annovis Bio reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Annovis Bio Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
52 Neutral | $254.26M | -4.14 | -53.89% | ― | -100.00% | -1813.57% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | $193.09M | -1.62 | -136.27% | ― | ― | 27.94% | |
47 Neutral | $205.08M | -2.65 | -91.60% | ― | 3472.96% | 67.74% | |
47 Neutral | $112.36M | -4.36 | -0.20% | ― | 1793.76% | 19.33% | |
45 Neutral | $78.70M | -0.97 | -9999.00% | ― | ― | 11.96% |
* Healthcare Sector Average
ANVS
Annovis Bio
1.74
-0.87
-33.33%
WHWK
Whitehawk Therapeutics
4.64
2.99
181.21%
DTIL
Precision BioSciences
7.40
2.60
54.17%
GLSI
Greenwich LifeSciences
17.38
5.91
51.53%
ABOS
Acumen Pharmaceuticals
2.66
1.28
92.75%
COYA
Coya Therapeutics, Inc.
4.67
-1.27
-21.38%
Annovis Bio Corporate Events
Business Operations and StrategyProduct-Related Announcements
Annovis Bio Completes Enrollment in Pivotal Alzheimer’s Trial
Positive
Jul 10, 2026
On July 7, 2026, Annovis Bio announced it had reached full enrollment in its pivotal Phase 3 trial testing buntanetap in patients with early Alzheimer’s disease. The study enrolled 850 patients with pTau217-confirmed Alzheimer’s pathol...
Business Operations and StrategyShareholder Meetings
Annovis Bio Shareholders Approve Governance and Compensation Changes
Positive
Jun 17, 2026
On June 17, 2026, Annovis Bio, Inc. held its 2026 Annual Meeting of Stockholders virtually, with 62.65% of outstanding common shares represented, and shareholders elected all five director nominees and ratified Ernst Young LLP as the company̵...
Business Operations and StrategyPrivate Placements and Financing
Annovis Bio Announces Dilutive Equity Offering for Trials
Negative
May 20, 2026
On May 20, 2026, Annovis Bio entered an underwriting agreement with Canaccord Genuity for a public offering of 7,895,000 common shares and accompanying warrants to purchase up to 7,105,500 shares, priced at a combined $1.90 per share and nine-tent...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.