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Adaptimmune Therapeutics Plc. (ADAPY)
:ADAPY
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Adaptimmune Therapeutics (ADAPY) AI Stock Analysis

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ADAPY

Adaptimmune Therapeutics

(ADAPY)

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Neutral 41 (OpenAI - 4o)
Rating:41Neutral
Price Target:
$0.00
▼(-100.00% Downside)
Adaptimmune Therapeutics is currently facing significant financial and operational challenges, as reflected in its low financial performance score. The technical analysis indicates a bearish trend, and the valuation metrics are unattractive due to ongoing losses. These factors collectively contribute to a low overall stock score.
Positive Factors
Proprietary TCR Technology
Adaptimmune's proprietary TCR technology provides a competitive edge in immunotherapy, potentially leading to breakthrough cancer treatments and long-term growth opportunities.
High Gross Profit Margin
A high gross profit margin indicates strong pricing power and cost management, which can support future profitability as revenue stabilizes.
Free Cash Flow Growth
Growth in free cash flow suggests improving operational efficiency, providing more resources for R&D and potential strategic investments.
Negative Factors
Declining Revenue
Significant revenue decline reflects challenges in product commercialization and market penetration, impacting long-term financial stability.
Negative Profitability
Ongoing negative profitability indicates operational inefficiencies and challenges in achieving sustainable financial performance.
Precarious Balance Sheet
A precarious balance sheet with negative equity suggests financial instability, potentially limiting the company's ability to secure financing.

Adaptimmune Therapeutics (ADAPY) vs. SPDR S&P 500 ETF (SPY)

Adaptimmune Therapeutics Business Overview & Revenue Model

Company DescriptionAdaptimmune Therapeutics plc, a clinical-stage biopharmaceutical company, focuses on providing novel cell therapies primarily to patients with solid tumors in the United States and the United Kingdom. The company's specific peptide enhanced affinity receptor (SPEAR) T-cell platform enables it to identify cancer targets. It is developing ADP-A2M4 that is in phase II clinical trials with SPEARHEAD-1 for synovial sarcoma and myxoid round cell liposarcoma indications (MRCLS); in phase II clinical trials with SPEARHEAD-2 for patients with head and neck cancer; and in phase I clinical trials for urothelial, melanoma, head and neck, ovarian, non-small cell lung, esophageal and gastric, synovial sarcoma, and MRCLS cancers. The company is also developing ADP-A2AFP, which is in phase I clinical trials for hepatocellular carcinoma; and ADP-A2M4CD8, which is in phase I clinical trial for SPEAR T-cells focusing on treating patients with lung, gastroesophageal, head and neck, ovarian, and bladder cancers. It has a collaboration and license agreement with GSK; third party collaborations with Noile-Immune Biotech Inc., Alpine Immune Sciences, Inc., and National Center for Cancer Immune Therapy in Denmark; strategic alliance agreement with the MD Anderson Cancer Center; and co-development and co-commercialization agreement with Universal Cells, Inc. Adaptimmune Therapeutics plc also has a strategic collaboration and license agreement with Genentech, Inc. and F. Hoffman-La Roche Ltd to develop personalized allogeneic T-cell therapies utilizing aß T-cell receptors. Adaptimmune Therapeutics plc was founded in 2008 and is headquartered in Abingdon, the United Kingdom.
How the Company Makes MoneyAdaptimmune Therapeutics generates revenue primarily through partnerships and collaborations with pharmaceutical companies, as well as through grants and funding from governmental and non-governmental organizations. The company may receive milestone payments as it progresses its therapies through clinical trials, and royalties from any future sales of products that arise from its collaborations. Additionally, Adaptimmune may also explore options for licensing its technology to other companies, which can provide further financial inflows. The success of its therapies in clinical trials and subsequent commercialization efforts are critical for its earning potential.

Adaptimmune Therapeutics Financial Statement Overview

Summary
Adaptimmune Therapeutics is facing significant financial challenges, including declining revenues, negative profitability, and a precarious balance sheet. Despite some improvement in free cash flow growth, the company's financial health remains weak, requiring strategic interventions to stabilize and improve its financial position.
Income Statement
Adaptimmune Therapeutics has experienced significant revenue volatility, with a sharp decline in TTM revenue growth of -63.77%. The company maintains a high gross profit margin of 98.06% in TTM, but this is overshadowed by negative net profit margins and EBIT margins, indicating ongoing operational challenges and profitability issues.
Balance Sheet
The balance sheet reveals a concerning financial structure with a negative stockholders' equity in TTM, leading to a negative debt-to-equity ratio. The return on equity is also negative, reflecting substantial losses relative to equity. These factors suggest financial instability and potential solvency risks.
Cash Flow
Cash flow analysis shows a significant free cash flow growth of 73.93% in TTM, but the company still faces negative operating cash flow and free cash flow figures. The operating cash flow to net income ratio is negative, indicating cash flow challenges relative to earnings.
Breakdown
Income Statement
Total Revenue
Gross Profit
EBITDA
Net Income
Balance Sheet
Total Assets
Cash, Cash Equivalents and Short-Term Investments
Total Debt
Total Liabilities
Stockholders Equity
Cash Flow
Free Cash Flow
Operating Cash Flow
Investing Cash Flow
Financing Cash Flow

Adaptimmune Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.06
Price Trends
50DMA
0.10
Negative
100DMA
0.15
Negative
200DMA
0.28
Negative
Market Momentum
MACD
-0.02
Positive
RSI
37.39
Neutral
STOCH
9.32
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ADAPY, the sentiment is Negative. The current price of 0.06 is below the 20-day moving average (MA) of 0.13, below the 50-day MA of 0.10, and below the 200-day MA of 0.28, indicating a bearish trend. The MACD of -0.02 indicates Positive momentum. The RSI at 37.39 is Neutral, neither overbought nor oversold. The STOCH value of 9.32 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for ADAPY.

Adaptimmune Therapeutics Risk Analysis

Adaptimmune Therapeutics disclosed 82 risk factors in its most recent earnings report. Adaptimmune Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Adaptimmune Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
$40.94M-1.03-277.74%536.44%63.68%
$51.05M-0.6916.14%31.01%
$7.86B-0.30-43.30%2.27%22.53%-2.21%
$54.41M-0.23-169.54%-100.00%29.21%
$38.93M-90.07%-32.55%-15.83%
-1341.37%-53.61%-93.14%
$36.06M-813.88%49.48%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ADAPY
Adaptimmune Therapeutics
0.05
-0.65
-92.86%
MRSN
Mersana Therapeutics
10.23
-38.27
-78.91%
BCAB
BioAtla
0.74
-1.27
-63.18%
LVTX
LAVA Therapeutics
1.61
-0.21
-11.54%
SNTI
Senti Biosciences
2.23
<0.01
0.45%
XLO
Xilio Therapeutics
0.82
-0.17
-17.17%

Adaptimmune Therapeutics Corporate Events

Adaptimmune’s SPEARHEAD-3 Study: A New Hope for Pediatric Cancer Treatment
Oct 27, 2025

Study Overview: The SPEARHEAD-3 Pediatric Study, officially titled A Phase 1/2 Open Label, Basket Study to Assess the Safety, Tolerability and Anti-Tumor Activity of Afamitresgene Autoleucel in Pediatric Subjects With MAGE-A4 Positive Tumors, aims to evaluate the safety and efficacy of afamitresgene autoleucel in children aged 2-17 with advanced cancers. This study is significant as it targets rare pediatric cancers, potentially offering new treatment options.

Business Operations and StrategyDelistings and Listing Changes
Adaptimmune Therapeutics to Delist from Nasdaq by October 27
Neutral
Oct 20, 2025

Adaptimmune Therapeutics announced its decision to voluntarily delist its American Depositary Shares from the Nasdaq Capital Market, effective after October 27, 2025, and to deregister under the Securities Exchange Act of 1934. This strategic move, following a transaction with US WorldMeds, aims to reduce costs and support the company’s focus on maximizing value from its remaining assets. The delisting will result in the suspension of filing obligations and may lead to trading on the OTC Pink Limited Market, though there are no guarantees of continued trading.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Delistings and Listing Changes
Adaptimmune Granted Exception Period by Nasdaq Panel
Neutral
Sep 26, 2025

On September 22, 2025, Adaptimmune Therapeutics received a notice from the Nasdaq Hearings Panel granting an exception period to comply with the Nasdaq Listing Rule requiring a minimum bid price of $1.00 per share. The company must meet this requirement by December 1, 2025, or face delisting from the Nasdaq Capital Market.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
Adaptimmune Faces Nasdaq Delisting Notice for Low Market Value
Negative
Sep 12, 2025

On September 11, 2025, Adaptimmune Therapeutics received a notice from Nasdaq indicating that its market value of listed securities had fallen below the $35 million minimum required for continued listing. The company has until March 10, 2026, to regain compliance, failing which its securities may be delisted from Nasdaq. The notice does not immediately affect the trading of its American Depositary Shares, but the company is exploring options to meet the compliance requirements.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Executive/Board Changes
Adaptimmune Appoints New CFO Christopher Hill
Neutral
Sep 8, 2025

On September 6, 2025, Adaptimmune Limited appointed Christopher Hill as Chief Financial Officer, effective September 10, 2025. Hill, with over a decade of experience in financial roles within life science companies, will manage the company’s accounting and finance functions as an independent contractor through a consulting agreement with CJH Financial Limited. This strategic appointment highlights Adaptimmune’s focus on strengthening its financial leadership as it continues to develop its therapeutic offerings.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Adaptimmune Announces Executive Team Changes Amid Restructuring
Negative
Aug 29, 2025

Adaptimmune Therapeutics announced changes in its executive team due to redundancy, affecting Gavin Wood, the Chief Financial Officer, and John Lunger, the Chief Patient Supply Officer. Mr. Wood’s employment will end on September 9, 2025, with a severance package including a year’s salary and other benefits, while Mr. Lunger’s termination is effective August 31, 2025, with similar severance terms. These changes reflect the company’s ongoing restructuring efforts, impacting its operational dynamics and potentially influencing stakeholder relations.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Executive/Board Changes
Adaptimmune Announces CCO Departure and Severance Agreement
Neutral
Aug 15, 2025

On August 15, 2025, Adaptimmune announced a separation agreement with Cintia Piccina, whose role as Chief Commercial Officer was terminated due to redundancy on August 8, 2025. As part of the agreement, Piccina will receive a severance payment equivalent to 12 months of her 2025 base salary, amounting to $473,800, and will have until January 30, 2032, to exercise her vested share options.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
Adaptimmune Faces Nasdaq Delisting Notice Amid Compliance Issues
Negative
Aug 14, 2025

Adaptimmune Therapeutics plc, a company involved in the biotechnology industry, faced compliance issues with Nasdaq’s listing rules due to its American Depositary Shares trading below the required minimum bid price. On November 1, 2024, the company was notified of non-compliance and given until April 30, 2025, to resolve the issue. Despite an extension granted on May 1, 2025, to October 27, 2025, the company’s shares continued to fall, prompting Nasdaq to issue a delisting notice on August 14, 2025. Adaptimmune intends to request a hearing to present its compliance plan and seek additional time to meet the listing requirements, with its shares remaining on the Nasdaq Capital Market under the symbol ‘ADAP’ during the process.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Adaptimmune Reports Growth and Strategic Moves in Q2
Aug 14, 2025

Adaptimmune Therapeutics Plc is a cell therapy company that focuses on developing engineered T cell receptor (TCR) therapies to treat solid tumor cancers, aiming to improve cancer treatment experiences for patients. In its recent earnings report, Adaptimmune highlighted significant growth in its TECELRA sales, reporting a 150% increase in revenue compared to the previous quarter. The company also announced a strategic transaction with US WorldMeds for the sale of several cell therapies, which provided a $55 million upfront payment and potential future milestone payments. Key financial metrics revealed a decrease in total revenue due to the termination of a collaboration with Genentech, while product revenue saw an increase following TECELRA’s FDA approval. The company also reported a net loss, attributed to restructuring and reduced R&D expenses. Looking ahead, Adaptimmune is focused on maximizing the value of its remaining assets and ensuring sufficient liquidity to meet its operating requirements over the next year.

Business Operations and StrategyExecutive/Board Changes
Adaptimmune Announces Termination of Chief Medical Officer
Negative
Aug 7, 2025

On August 7, 2025, Adaptimmune announced the termination of Dr. Elliot Norry as Chief Medical Officer, effective August 8, 2025, due to redundancy. Dr. Norry will receive a severance package including a year’s salary and healthcare coverage. Similarly, Dr. Joanna Brewer’s role as Chief Scientific Officer will end on August 31, 2025, with a similar severance arrangement. Gavin Wood’s termination as Chief Financial Officer, initially announced in December 2024, will also conclude on August 31, 2025, with a severance package including a year’s salary and a pro rata bonus. These changes reflect a strategic restructuring within the company.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Business Operations and StrategyM&A Transactions
Adaptimmune Sells Cell Therapy Assets for $55 Million
Positive
Jul 31, 2025

On July 31, 2025, Adaptimmune Therapeutics completed a significant transaction involving the sale of its cell therapy assets to USWM CT, LLC, receiving $55 million and potential future milestone payments. This transaction also allowed Adaptimmune to settle its $29.1 million debt with Hercules Capital, thereby improving its financial position and potentially impacting its future operations and market strategy.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Business Operations and StrategyExecutive/Board ChangesM&A Transactions
Adaptimmune Sells Cell Therapy Assets to US WorldMeds
Negative
Jul 28, 2025

On July 27, 2025, Adaptimmune Therapeutics entered into an agreement to sell its cell therapy assets, including TECELRA, lete-cel, afami-cel, and uza-cel, to US WorldMeds for $55 million, with potential additional payments of up to $30 million based on milestone achievements. This transaction is part of a broader restructuring plan by Adaptimmune to maximize value from its remaining assets and involves significant workforce reductions. The restructuring will see key executives depart and is expected to incur pre-tax costs of approximately $7-8 million. The transaction aims to ensure the continued availability of TECELRA to patients and support the development of other therapies by US WorldMeds.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 28, 2025