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Adaptimmune Therapeutics Plc. (ADAP)
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Adaptimmune Therapeutics (ADAP) AI Stock Analysis

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ADAP

Adaptimmune Therapeutics

(NASDAQ:ADAP)

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Underperform 40 (OpenAI - 4o)
Rating:40Underperform
Price Target:
$0.00
▼(-100.00% Downside)
Adaptimmune Therapeutics' overall stock score is primarily impacted by its weak financial performance and poor valuation metrics. The technical analysis also indicates a bearish trend, further contributing to the low score. The absence of earnings call data and corporate events means these factors do not influence the score.
Positive Factors
Proprietary TCR Technology
Adaptimmune's proprietary TCR technology provides a competitive edge in immunotherapy, potentially leading to breakthrough cancer treatments and long-term growth opportunities.
High Gross Profit Margin
A high gross profit margin indicates strong pricing power and cost management, which can support future profitability as revenue stabilizes.
Free Cash Flow Growth
Growth in free cash flow suggests improving operational efficiency, providing more resources for R&D and potential strategic investments.
Negative Factors
Declining Revenue
Significant revenue decline reflects challenges in product commercialization and market penetration, impacting long-term financial stability.
Negative Profitability
Ongoing negative profitability indicates operational inefficiencies and challenges in achieving sustainable financial performance.
Precarious Balance Sheet
A precarious balance sheet with negative equity suggests financial instability, potentially limiting the company's ability to secure financing.

Adaptimmune Therapeutics (ADAP) vs. SPDR S&P 500 ETF (SPY)

Adaptimmune Therapeutics Business Overview & Revenue Model

Company DescriptionAdaptimmune Therapeutics plc is a clinical-stage biotechnology company focused on the development of T-cell therapies to treat cancer. Headquartered in Oxford, UK, the company specializes in the field of immunotherapy, particularly utilizing its proprietary T-cell receptor (TCR) technology to engineer T-cells that can target and destroy cancer cells. Adaptimmune is primarily engaged in developing therapies for various cancers, including solid tumors and hematological malignancies, with key products like SPEAR T-cell therapies that are designed to enhance the body’s immune response against cancer.
How the Company Makes MoneyAdaptimmune Therapeutics generates revenue primarily through partnerships and collaborations with pharmaceutical companies, as well as through grants and funding from governmental and non-governmental organizations. The company may receive milestone payments as it progresses its therapies through clinical trials, and royalties from any future sales of products that arise from its collaborations. Additionally, Adaptimmune may also explore options for licensing its technology to other companies, which can provide further financial inflows. The success of its therapies in clinical trials and subsequent commercialization efforts are critical for its earning potential.

Adaptimmune Therapeutics Earnings Call Summary

Earnings Call Date:Aug 13, 2025
(Q1-2025)
|
% Change Since: |
Next Earnings Date:Nov 05, 2025
Earnings Call Sentiment Positive
Adaptimmune reported a very successful launch of TECELRA with strong initial sales and effective patient access. The early activation of treatment centers and manufacturing success further support their positive outlook. However, financial challenges remain with doubts about their ability to continue as a going concern.
Q1-2025 Updates
Positive Updates
Strong TECELRA Launch with Revenue Guidance
Adaptimmune reported a successful launch of TECELRA with 21 patients apheresed in 2025, 13 in Q1 and 8 in early Q2. They provided revenue guidance for the full year of $35 million to $45 million in TECELRA sales.
Early Activation of Treatment Centers
Adaptimmune has 28 treatment centers accepting referrals and expects to have a full network of 30 centers by the end of 2025, a year earlier than expected.
100% Manufacturing Success
The TECELRA manufacturing center in Philadelphia reported 100% success with all doses released meeting specifications, and an average turnaround time of 27 days, beating the target of 30 days.
No Patient Denials
Effective patient access to TECELRA with no patient denials reported to date.
Future Growth with lete-cel
Anticipation of lete-cel approval in 2026, which could more than double the addressable patient market within the sarcoma franchise.
Negative Updates
Substantial Doubt About Going Concern
The company reported substantial doubt about its ability to continue as a going concern, indicating less than 12 months of cash available and uncertainty in cash runway guidance.
Company Guidance
In the first quarter of 2025, Adaptimmune reported significant progress in the launch of TECELRA, with 21 patients apheresed to date, including 13 in Q1 and 8 in early Q2. The company provided revenue guidance for the full year, anticipating TECELRA sales of $35 million to $45 million. Adaptimmune reported invoicing 14 TECELRA treatments in 2025, including 6 in Q1, resulting in $4 million in net sales, and 8 additional invoiced treatments early in Q2. The company achieved 100% manufacturing success, with an average turnaround from apheresis to lot release of 27 days, surpassing the 30-day target. Adaptimmune's network includes 28 active treatment centers, with expectations to reach 30 by year-end, a year ahead of schedule. No patient access issues have been reported, with no denials to date. Adaptimmune foresees peak sales of $400 million from its TECELRA and lete-cel sarcoma franchise, with lete-cel launch activities underway, targeting a 2026 approval.

Adaptimmune Therapeutics Financial Statement Overview

Summary
Adaptimmune Therapeutics is facing significant financial challenges, including declining revenues, negative profitability, and a precarious balance sheet. Despite some improvement in free cash flow growth, the company's financial health remains weak, requiring strategic interventions to stabilize and improve its financial position.
Income Statement
30
Negative
Adaptimmune Therapeutics has experienced significant revenue volatility, with a sharp decline in TTM revenue growth of -63.77%. The company maintains a high gross profit margin of 98.06% in TTM, but this is overshadowed by negative net profit margins and EBIT margins, indicating ongoing operational challenges and profitability issues.
Balance Sheet
20
Very Negative
The balance sheet reveals a concerning financial structure with a negative stockholders' equity in TTM, leading to a negative debt-to-equity ratio. The return on equity is also negative, reflecting substantial losses relative to equity. These factors suggest financial instability and potential solvency risks.
Cash Flow
25
Negative
Cash flow analysis shows a significant free cash flow growth of 73.93% in TTM, but the company still faces negative operating cash flow and free cash flow figures. The operating cash flow to net income ratio is negative, indicating cash flow challenges relative to earnings.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue65.08M178.03M60.28M27.15M6.15M3.96M
Gross Profit61.70M177.96M50.42M-100.58M-104.94M-87.61M
EBITDA-149.75M-52.66M-128.20M-155.59M-155.68M-125.81M
Net Income-169.76M-70.81M-113.87M-165.46M-158.09M-130.09M
Balance Sheet
Total Assets130.63M245.96M282.62M328.92M469.55M451.14M
Cash, Cash Equivalents and Short-Term Investments26.06M151.60M146.94M204.60M369.58M368.22M
Total Debt48.68M74.21M25.23M23.08M25.47M23.71M
Total Liabilities201.59M234.11M243.10M247.04M263.58M109.92M
Stockholders Equity-70.96M11.85M39.51M81.88M205.96M341.23M
Cash Flow
Free Cash Flow-191.71M-75.93M-145.76M-171.51M1.95M-56.50M
Operating Cash Flow-190.03M-73.21M-140.88M-141.77M10.73M-53.59M
Investing Cash Flow1.79M-58.95M176.54M89.14M75.80M-278.92M
Financing Cash Flow1.34M78.75M880.00K12.87M3.29M340.05M

Adaptimmune Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.06
Price Trends
50DMA
0.10
Negative
100DMA
0.16
Negative
200DMA
0.29
Negative
Market Momentum
MACD
>-0.01
Positive
RSI
40.07
Neutral
STOCH
6.80
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ADAP, the sentiment is Negative. The current price of 0.06 is below the 20-day moving average (MA) of 0.15, below the 50-day MA of 0.10, and below the 200-day MA of 0.29, indicating a bearish trend. The MACD of >-0.01 indicates Positive momentum. The RSI at 40.07 is Neutral, neither overbought nor oversold. The STOCH value of 6.80 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for ADAP.

Adaptimmune Therapeutics Risk Analysis

Adaptimmune Therapeutics disclosed 82 risk factors in its most recent earnings report. Adaptimmune Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Adaptimmune Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
54
Neutral
$38.52M-277.74%536.44%63.68%
52
Neutral
$52.00M16.14%31.01%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
$56.24M-169.54%-100.00%29.21%
44
Neutral
$38.93M-90.07%-32.55%-15.83%
40
Underperform
$12.88M-1341.37%-53.61%-93.14%
35
Underperform
$36.06M-813.88%49.48%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ADAP
Adaptimmune Therapeutics
0.07
-0.68
-90.67%
MRSN
Mersana Therapeutics
9.19
-41.06
-81.71%
BCAB
BioAtla
0.66
-1.25
-65.45%
LVTX
LAVA Therapeutics
1.63
-0.37
-18.50%
SNTI
Senti Biosciences
1.98
-0.16
-7.48%
XLO
Xilio Therapeutics
0.75
-0.18
-19.35%

Adaptimmune Therapeutics Corporate Events

Business Operations and StrategyDelistings and Listing Changes
Adaptimmune Therapeutics to Delist from Nasdaq by October 27
Neutral
Oct 20, 2025

Adaptimmune Therapeutics announced its decision to voluntarily delist its American Depositary Shares from the Nasdaq Capital Market, effective after October 27, 2025, and to deregister under the Securities Exchange Act of 1934. This strategic move, following a transaction with US WorldMeds, aims to reduce costs and support the company’s focus on maximizing value from its remaining assets. The delisting will result in the suspension of filing obligations and may lead to trading on the OTC Pink Limited Market, though there are no guarantees of continued trading.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Delistings and Listing Changes
Adaptimmune Granted Exception Period by Nasdaq Panel
Neutral
Sep 26, 2025

On September 22, 2025, Adaptimmune Therapeutics received a notice from the Nasdaq Hearings Panel granting an exception period to comply with the Nasdaq Listing Rule requiring a minimum bid price of $1.00 per share. The company must meet this requirement by December 1, 2025, or face delisting from the Nasdaq Capital Market.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
Adaptimmune Faces Nasdaq Delisting Notice for Low Market Value
Negative
Sep 12, 2025

On September 11, 2025, Adaptimmune Therapeutics received a notice from Nasdaq indicating that its market value of listed securities had fallen below the $35 million minimum required for continued listing. The company has until March 10, 2026, to regain compliance, failing which its securities may be delisted from Nasdaq. The notice does not immediately affect the trading of its American Depositary Shares, but the company is exploring options to meet the compliance requirements.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Executive/Board Changes
Adaptimmune Appoints New CFO Christopher Hill
Neutral
Sep 8, 2025

On September 6, 2025, Adaptimmune Limited appointed Christopher Hill as Chief Financial Officer, effective September 10, 2025. Hill, with over a decade of experience in financial roles within life science companies, will manage the company’s accounting and finance functions as an independent contractor through a consulting agreement with CJH Financial Limited. This strategic appointment highlights Adaptimmune’s focus on strengthening its financial leadership as it continues to develop its therapeutic offerings.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Adaptimmune Announces Executive Team Changes Amid Restructuring
Negative
Aug 29, 2025

Adaptimmune Therapeutics announced changes in its executive team due to redundancy, affecting Gavin Wood, the Chief Financial Officer, and John Lunger, the Chief Patient Supply Officer. Mr. Wood’s employment will end on September 9, 2025, with a severance package including a year’s salary and other benefits, while Mr. Lunger’s termination is effective August 31, 2025, with similar severance terms. These changes reflect the company’s ongoing restructuring efforts, impacting its operational dynamics and potentially influencing stakeholder relations.

The most recent analyst rating on (ADAP) stock is a Sell with a $0.46 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Executive/Board Changes
Adaptimmune Announces CCO Departure and Severance Agreement
Neutral
Aug 15, 2025

On August 15, 2025, Adaptimmune announced a separation agreement with Cintia Piccina, whose role as Chief Commercial Officer was terminated due to redundancy on August 8, 2025. As part of the agreement, Piccina will receive a severance payment equivalent to 12 months of her 2025 base salary, amounting to $473,800, and will have until January 30, 2032, to exercise her vested share options.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
Adaptimmune Faces Nasdaq Delisting Notice Amid Compliance Issues
Negative
Aug 14, 2025

Adaptimmune Therapeutics plc, a company involved in the biotechnology industry, faced compliance issues with Nasdaq’s listing rules due to its American Depositary Shares trading below the required minimum bid price. On November 1, 2024, the company was notified of non-compliance and given until April 30, 2025, to resolve the issue. Despite an extension granted on May 1, 2025, to October 27, 2025, the company’s shares continued to fall, prompting Nasdaq to issue a delisting notice on August 14, 2025. Adaptimmune intends to request a hearing to present its compliance plan and seek additional time to meet the listing requirements, with its shares remaining on the Nasdaq Capital Market under the symbol ‘ADAP’ during the process.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Adaptimmune Reports Growth and Strategic Moves in Q2
Aug 14, 2025

Adaptimmune Therapeutics Plc is a cell therapy company that focuses on developing engineered T cell receptor (TCR) therapies to treat solid tumor cancers, aiming to improve cancer treatment experiences for patients. In its recent earnings report, Adaptimmune highlighted significant growth in its TECELRA sales, reporting a 150% increase in revenue compared to the previous quarter. The company also announced a strategic transaction with US WorldMeds for the sale of several cell therapies, which provided a $55 million upfront payment and potential future milestone payments. Key financial metrics revealed a decrease in total revenue due to the termination of a collaboration with Genentech, while product revenue saw an increase following TECELRA’s FDA approval. The company also reported a net loss, attributed to restructuring and reduced R&D expenses. Looking ahead, Adaptimmune is focused on maximizing the value of its remaining assets and ensuring sufficient liquidity to meet its operating requirements over the next year.

Business Operations and StrategyExecutive/Board Changes
Adaptimmune Announces Termination of Chief Medical Officer
Negative
Aug 7, 2025

On August 7, 2025, Adaptimmune announced the termination of Dr. Elliot Norry as Chief Medical Officer, effective August 8, 2025, due to redundancy. Dr. Norry will receive a severance package including a year’s salary and healthcare coverage. Similarly, Dr. Joanna Brewer’s role as Chief Scientific Officer will end on August 31, 2025, with a similar severance arrangement. Gavin Wood’s termination as Chief Financial Officer, initially announced in December 2024, will also conclude on August 31, 2025, with a severance package including a year’s salary and a pro rata bonus. These changes reflect a strategic restructuring within the company.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Business Operations and StrategyM&A Transactions
Adaptimmune Sells Cell Therapy Assets for $55 Million
Positive
Jul 31, 2025

On July 31, 2025, Adaptimmune Therapeutics completed a significant transaction involving the sale of its cell therapy assets to USWM CT, LLC, receiving $55 million and potential future milestone payments. This transaction also allowed Adaptimmune to settle its $29.1 million debt with Hercules Capital, thereby improving its financial position and potentially impacting its future operations and market strategy.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Business Operations and StrategyExecutive/Board ChangesM&A Transactions
Adaptimmune Sells Cell Therapy Assets to US WorldMeds
Negative
Jul 28, 2025

On July 27, 2025, Adaptimmune Therapeutics entered into an agreement to sell its cell therapy assets, including TECELRA, lete-cel, afami-cel, and uza-cel, to US WorldMeds for $55 million, with potential additional payments of up to $30 million based on milestone achievements. This transaction is part of a broader restructuring plan by Adaptimmune to maximize value from its remaining assets and involves significant workforce reductions. The restructuring will see key executives depart and is expected to incur pre-tax costs of approximately $7-8 million. The transaction aims to ensure the continued availability of TECELRA to patients and support the development of other therapies by US WorldMeds.

The most recent analyst rating on (ADAP) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Adaptimmune Therapeutics stock, see the ADAP Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 23, 2025