tiprankstipranks
Trending News
More News >
Voyager Therapeutics Inc. (VYGR)
:VYGR
Advertisement

Voyager Therapeutics (VYGR) AI Stock Analysis

Compare
1,256 Followers

Top Page

VYGR

Voyager Therapeutics

(NASDAQ:VYGR)

Select Model
Select Model
Select Model
Neutral 58 (OpenAI - 4o)
Rating:58Neutral
Price Target:
$4.50
▼(-7.41% Downside)
Voyager Therapeutics' overall stock score is primarily influenced by its financial performance challenges, including negative profit margins and fluctuating cash flows. However, positive technical indicators and strategic corporate events provide some optimism. The valuation remains a concern due to ongoing losses, but the company's participation in industry conferences and strategic advancements offer potential for future growth.
Positive Factors
Strategic Advancements
Voyager's participation in the conference underscores its commitment to advancing its pipeline and strengthening its industry position, which is crucial for long-term growth and competitiveness in the biotech sector.
Innovative Gene Therapy Platform
The proprietary AAV vector platform positions Voyager as a leader in gene therapy for neurological diseases, providing a competitive edge in developing innovative treatments for unmet medical needs.
Non-Dilutive Funding
Non-dilutive funding enhances Voyager's financial stability, allowing it to pursue R&D and clinical milestones without diluting shareholder value, supporting sustainable growth.
Negative Factors
Revenue Volatility
The decline in revenue growth highlights challenges in achieving consistent revenue streams, which can impact long-term financial stability and investment attractiveness.
Negative Profit Margins
Ongoing negative profit margins indicate operational challenges and hinder the company's ability to generate sustainable profits, affecting long-term viability.
Fluctuating Cash Flows
Instability in cash flow management can strain financial resources, limiting Voyager's ability to invest in R&D and strategic initiatives, impacting future growth potential.

Voyager Therapeutics (VYGR) vs. SPDR S&P 500 ETF (SPY)

Voyager Therapeutics Business Overview & Revenue Model

Company DescriptionVoyager Therapeutics, Inc., a gene therapy company, focuses on the development of treatments and next-generation platform technologies. The company's lead clinical candidate is the VY-AADC, which is in open-label Phase 1 clinical trial for the treatment of Parkinson's disease. Its preclinical programs comprise VY-SOD102 for the treatment of amyotrophic lateral sclerosis; VY-HTT01 for Huntington's disease; VY-FXN01 for Friedreich's ataxia; and Tau program for the treatment of tauopathies, including Alzheimer's disease, progressive supranuclear palsy, and frontotemporal dementia, as well as for spinal muscular atrophy. The company has collaboration and license agreements with Neurocrine Biosciences, Inc., Pfizer Inc., and Novartis Pharma, A.G. for the research, development, and commercialization of adeno-associated virus gene therapy products. Voyager Therapeutics, Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.
How the Company Makes MoneyVoyager Therapeutics generates revenue primarily through partnerships and collaborations with larger pharmaceutical companies, which may include upfront payments, milestone payments tied to the achievement of specific development goals, and royalties on product sales. Additionally, the company may receive funding from grants or government programs aimed at advancing research in gene therapy. Their revenue model is heavily dependent on the successful progression of their clinical trials and the commercialization of their therapies, as well as maintaining strong relationships with industry partners to enhance their product pipeline and potential market reach.

Voyager Therapeutics Earnings Call Summary

Earnings Call Date:Aug 06, 2025
(Q4-2024)
|
% Change Since: |
Next Earnings Date:Nov 18, 2025
Earnings Call Sentiment Positive
The earnings call presented a positive outlook with significant advancements and strong financial positioning. Despite a setback in the SOD1 silencing program, the progress in tau-targeting therapies and potential substantial milestone payments from partnerships highlight a promising future.
Q4-2024 Updates
Positive Updates
Strong Cash Position and Potential Milestone Payments
Voyager Therapeutics reported $332 million in cash as of the end of 2024, with potential future milestone payments totaling $8.2 billion from partnerships.
Advancements in Tau Silencing Program
The tau silencing gene therapy program, VY1706, moved forward into IND-enabling studies, showing 50% to 73% knockdown of tau messenger RNA in non-human primate studies.
Positive Results for Anti-Tau Antibody VY7523
VY7523 performed well in a single ascending dose study with no serious adverse events, showing dose-proportional pharmacokinetics and a CSF to serum ratio of 0.3%.
Promising External Data Supporting Anti-Tau Strategies
UCB's bepranemab demonstrated impact on tau accumulation, and further data from Merck and other companies are anticipated, which may support the potential of tau-targeted therapies.
Progress in Partnered Programs with Neurocrine
Two programs with Neurocrine are expected to enter the clinic or have an IND filed this year, indicating positive collaboration progress.
Negative Updates
Setback in SOD1 Silencing Gene Therapy Program
The SOD1 silencing gene therapy program moved back into the research stage due to the payload not meeting the target profile, requiring the identification of a new payload.
Challenges in Establishing Capsid Proof of Concept
The company is looking to establish capsid proof of concept through upcoming programs with Neurocrine, following complications with the SOD1 program.
Company Guidance
During the Voyager Therapeutics Fourth Quarter and Year-End 2024 Financial Results Conference Call, the company provided several key metrics and updates about their progress and future plans. Voyager reported $332 million in cash as of the end of 2024 and highlighted potential future milestone payments totaling $8.2 billion, emphasizing the significance of their partnerships as a source of non-dilutive revenue. The company is advancing its tau silencing gene therapy, VY1706, into IND-enabling studies, targeting IND submission in 2026, with promising non-human primate study results showing 50% to 73% knockdown of tau messenger RNA across the brain. Additionally, the anti-tau antibody, VY7523, showed favorable results in a single ascending dose study, with a CSF to serum ratio of 0.3%. Voyager expects initial tau PET data from a multiple ascending dose study in Alzheimer's patients in the second half of 2026. They also noted their $2.9 billion in developmental milestones and guidance extending their cash runway to mid-2027.

Voyager Therapeutics Financial Statement Overview

Summary
Voyager Therapeutics is facing financial challenges with declining revenues and profitability. The balance sheet shows a stable equity position, but increasing leverage and negative cash flows are concerns. The company needs to address operational inefficiencies to improve financial health.
Income Statement
45
Neutral
Voyager Therapeutics has experienced significant revenue volatility, with a notable decline in revenue from 2023 to TTM. The gross profit margin has decreased, and the company is currently operating at a net loss, impacting net profit margins negatively. The EBIT and EBITDA margins are also negative, indicating operational challenges.
Balance Sheet
55
Neutral
The company maintains a strong equity position with a high equity ratio, suggesting financial stability. However, the debt-to-equity ratio has increased slightly, indicating a rise in leverage. Return on equity is negative due to net losses, which is a concern for profitability.
Cash Flow
50
Neutral
Operating cash flow is negative, reflecting cash burn, but the company has managed to maintain a positive free cash flow growth rate in TTM. The operating cash flow to net income ratio is unfavorable due to negative net income, indicating cash flow challenges.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue42.58M80.00M250.01M40.91M37.41M171.13M
Gross Profit42.58M80.00M245.57M34.72M-36.37M62.38M
EBITDA-119.17M-78.56M126.45M-44.65M-68.45M31.20M
Net Income-107.93M-65.00M132.33M-46.41M-66.03M36.74M
Balance Sheet
Total Assets322.10M393.05M351.28M159.36M193.85M261.58M
Cash, Cash Equivalents and Short-Term Investments215.59M266.68M230.88M118.85M132.54M181.14M
Total Debt40.20M43.73M20.29M23.13M44.18M47.61M
Total Liabilities78.16M93.29M114.96M100.34M98.80M107.26M
Stockholders Equity243.94M299.76M236.32M59.02M95.06M154.32M
Cash Flow
Free Cash Flow-115.83M-18.83M74.66M-15.00M-55.13M-108.81M
Operating Cash Flow-113.65M-15.31M77.92M-12.51M-53.52M-96.72M
Investing Cash Flow80.28M-94.86M-141.64M-7.34M65.91M113.00M
Financing Cash Flow1.18M114.02M33.65M1.11M612.00K3.16M

Voyager Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price4.86
Price Trends
50DMA
3.81
Positive
100DMA
3.50
Positive
200DMA
3.95
Positive
Market Momentum
MACD
0.26
Negative
RSI
68.32
Neutral
STOCH
81.79
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For VYGR, the sentiment is Positive. The current price of 4.86 is above the 20-day moving average (MA) of 4.36, above the 50-day MA of 3.81, and above the 200-day MA of 3.95, indicating a bullish trend. The MACD of 0.26 indicates Negative momentum. The RSI at 68.32 is Neutral, neither overbought nor oversold. The STOCH value of 81.79 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for VYGR.

Voyager Therapeutics Risk Analysis

Voyager Therapeutics disclosed 72 risk factors in its most recent earnings report. Voyager Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Voyager Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
58
Neutral
$269.58M5.05-37.26%-70.38%-683.06%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
$236.17M-99.23%
39
Underperform
$268.86M-938.38%
36
Underperform
$264.02M-85.21%38.94%
36
Underperform
$238.72M-61.29%-39.69%
35
Underperform
$272.26M48.74%17.80%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
VYGR
Voyager Therapeutics
4.86
-1.93
-28.42%
GALT
Galectin Therapeutics
4.33
1.67
62.78%
RNAC
Cartesian Therapeutics
10.19
-12.52
-55.13%
SLN
Silence Therapeutics
5.00
-13.61
-73.13%
TNYA
Tenaya Therapeutics
1.62
-0.15
-8.47%
KYTX
Kyverna Therapeutics, Inc.
5.52
1.07
24.04%

Voyager Therapeutics Corporate Events

Business Operations and Strategy
Voyager Therapeutics Joins Citi’s Biopharma Conference 2025
Positive
Sep 2, 2025

Voyager Therapeutics announced its participation in Citi’s 2025 Biopharma Back to School Conference, highlighting its strategic advancements in neurotherapeutics. The company aims to optimize the delivery of therapeutics to the central nervous system through its innovative platforms, and anticipates significant clinical milestones in the coming years. This announcement underscores Voyager’s commitment to advancing its pipeline and strengthening its industry position, supported by substantial non-dilutive funding and collaborations.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Sep 08, 2025