Want to see RCUS full AI Analyst Report?
Top Page
Arcus Biosciences
(NYSE:RCUS)
Select Model
Select Model
Rating:51Neutral
Price Target:
$19.50
▼(-36.25% Downside)
Action:Reiterated
Date:10/23/26
RCUS scores as a high-risk biotech: the biggest drag is weak financial performance driven by large ongoing losses and significant negative free cash flow, alongside a bearish technical trend with negative momentum. Offsetting factors include a relatively constructive earnings update with defined clinical catalysts and runway guidance, plus supportive recent corporate events (new data and a sizable capital raise improving liquidity).
Positive Factors
Advancing Casdatifan Pipeline
Defined registrational timelines and a broad ARC-20 dataset create identifiable clinical value inflection points. Progress across first-line and later-line settings could expand casdatifan’s addressable market and strengthen Arcus’s oncology position if efficacy and safety remain supportive.
Negative Factors
Heavy Cash Burn
Sustained negative operating and free cash flow shows that Arcus is consuming substantial capital while its pipeline remains uncommercialized. Continued burn can increase dependence on additional financing and may constrain strategic flexibility if clinical programs take longer or require more investment.
Read all positive and negative factors
Positive Factors
Negative Factors
Advancing Casdatifan Pipeline
Defined registrational timelines and a broad ARC-20 dataset create identifiable clinical value inflection points. Progress across first-line and later-line settings could expand casdatifan’s addressable market and strengthen Arcus’s oncology position if efficacy and safety remain supportive.
Read all positive factors
Arcus Biosciences Key Performance Indicators (KPIs)
Any
Revenue by Segment
Breaks down revenue by different business units or product lines, highlighting which areas are driving growth and which may need strategic adjustments.
Breaks down revenue by different business units or product lines, highlighting which areas are driving growth and which may need strategic adjustments.
Data provided by:
The Fly
The FlyArcus Biosciences (RCUS) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$2.36B
Dividend YieldN/A
Average Volume (3M)2.16M
Price to Earnings (P/E)―
Beta (1Y)1.70
Revenue Growth-55.34%
EPS Growth-23.18%
CountryUS
Employees601
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-3.93
Shares Outstanding127,333,374
10 Day Avg. Volume3,015,840
30 Day Avg. Volume2,164,079
Financial Highlights & Ratios
PEG Ratio-1.52
Price to Book (P/B)4.06
Price to Sales (P/S)10.36
P/FCF Ratio-5.29
Enterprise Value/Market Cap1.40
Enterprise Value/Revenue28.20
Enterprise Value/Gross Profit30.00
Enterprise Value/Ebitda-7.88
Forecast
1Y Price Target
$40.25Price Target Upside31.58% Upside
Rating ConsensusModerate Buy
Number of Analyst Covering13
EPS Forecast (FY)-3.55
Revenue Forecast (FY)$73.15M
Arcus Biosciences Business Overview & Revenue Model
Company Description
Arcus Biosciences, Inc., a clinical-stage biopharmaceutical company, develops and commercializes cancer therapies in the United States. The company’s development product portfolio includes Casdatifan, a HIF-2a inhibitor for the treatment of kidney...
How the Company Makes Money
Arcus Biosciences does not primarily generate revenue from commercial product sales because, as a clinical-stage company, it has not historically relied on approved, marketed drugs as a core earnings base (commercial product revenue information: n...
Arcus Biosciences Earnings Call Summary
Earnings Call Date:Aug 05, 2026
(Q2-2026)
| % Change Since: |
Next Earnings Date:Nov 04, 2026
Earnings Call Sentiment Positive
The call emphasized multiple substantial clinical and business positives: strong translational validation (Nature paper), robust development progress for casdatifan with clear registrational timelines (PEAK‑1 enrollment on track and PEAK‑20 planned), multiple strategic collaborations, a broad immunology pipeline with near‑term IND milestones (AB102, TNFR1), and a solid cash runway into H2 2028. Key near‑term risks include a meaningful quarter‑over‑quarter cash reduction (~11.5%), expected declines in collaboration revenue from the Gilead wind‑down, high R&D spend with planned concentration (>80%) on casdatifan by 2027, and dependence on upcoming clinical readouts to validate the growth and revenue thesis. On balance, the highlights — clinical progress, partnerships, translational evidence, and adequate runway — outweigh the lowlights, which are primarily financial/timing and execution risks.Positive Updates
Casdatifan Market Opportunity and Peak Sales Outlook
Management projects a total peak sales opportunity for casdatifan of $5–$10 billion, citing RCC sales in major markets expected to reach roughly $13 billion by 2030. Specific line opportunities highlighted: ~20,000 IO‑experienced patients (~$2B opportunity) and >$4B first‑line opportunity.
Negative Updates
Quarterly Cash Decline
Cash and investments decreased from $876M at the end of Q1 to $775M at June 30, 2026 — a decline of $101M (~11.5%) quarter‑over‑quarter, though management still forecasts runway into H2 2028.
Read all updates
Q2-2026 Updates
Positive
Negative
Casdatifan Market Opportunity and Peak Sales Outlook
Management projects a total peak sales opportunity for casdatifan of $5–$10 billion, citing RCC sales in major markets expected to reach roughly $13 billion by 2030. Specific line opportunities highlighted: ~20,000 IO‑experienced patients (~$2B opportunity) and >$4B first‑line opportunity.
Read all positive updates
Company Guidance
Management provided specific near- and medium-term guidance: as of June 30, 2026 Arcus had $775M cash and investments (down from $876M at March 31), expects to end 2026 with ~ $600M and to have runway into at least H2 2028; Q2 GAAP revenue was $41M with full-year 2026 GAAP revenue guided to $65–75M; Q2 R&D expense was $113M (net) with R&D expected to meaningfully decline in 2026–27 and >80% of 2027 portfolio spend directed to casdatifan, G&A was $24M and non-cash stock‑based comp $15M in Q2. Clinical and commercial timelines: PEAK‑1 (cas + cabozantinib) remains on track to complete enrollment by year‑end 2026, PEAK‑20 (first‑line registrational trial) to start by year‑end 2026, ARC‑20 will deliver a broad October data package from >200 patients (including a first‑line cas+zim cohort with 30 patients and a 7% primary progression rate, a cas+zim ORR readout with ~11 months follow‑up, a second‑line cas+cabo cohort of ~45 patients with ≥18 months follow‑up, and ~120 late‑line monotherapy patients with ~28 months median follow‑up), PRISM‑1 (quemliclustat in pancreatic cancer) is expected to read out in H1 next year, AB102 dosing begins this month with PK data in Q4 and a TNFR1 program entering clinic in early 2027. Finally, market and value context: Arcus projects RCC sales in major markets to reach ~$13B by 2030, estimates PEAK‑1 addresses ~20,000 IO‑experienced patients (> $2B opportunity), first‑line > $4B, and total peak sales opportunity for casdatifan of $5–10B.Arcus Biosciences Financial Statement Overview
Summary
Income Statement
24
Negative
Balance Sheet
56
Neutral
Cash Flow
18
Very Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 117.00M | 247.00M | 258.00M | 117.00M | 112.00M | 383.00M |
| Gross Profit | 110.00M | 237.00M | 258.00M | 117.00M | 112.00M | 383.00M |
| EBITDA | -419.00M | -335.00M | -269.00M | -291.00M | -258.00M | 59.00M |
| Net Income | -452.00M | -353.00M | -283.00M | -307.00M | -267.00M | 53.00M |
Balance Sheet | ||||||
| Total Assets | 924.00M | 1.14B | 1.15B | 1.09B | 1.34B | 1.59B |
| Cash, Cash Equivalents and Short-Term Investments | 702.00M | 981.00M | 978.00M | 759.00M | 1.01B | 499.31M |
| Total Debt | 114.00M | 112.00M | 60.00M | 11.00M | 120.00M | 121.99M |
| Total Liabilities | 460.00M | 508.00M | 665.00M | 633.00M | 688.00M | 750.45M |
| Stockholders Equity | 464.00M | 631.00M | 485.00M | 462.00M | 657.00M | 841.45M |
Cash Flow | ||||||
| Free Cash Flow | -475.00M | -484.00M | -176.00M | -330.00M | 432.00M | -282.25M |
| Operating Cash Flow | -474.00M | -482.00M | -170.00M | -306.00M | 438.00M | -256.17M |
| Investing Cash Flow | 63.00M | 66.00M | -84.00M | 194.00M | -413.00M | -3.87M |
| Financing Cash Flow | 313.00M | 488.00M | 277.00M | 33.00M | 33.00M | 237.34M |
Arcus Biosciences Technical Analysis
Negative
30.59
Price Trends
26.12
Negative
26.85
Negative
24.76
Negative
Market Momentum
-1.70
Positive
27.51
Positive
14.60
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For RCUS, the sentiment is Negative. The current price of 30.59 is above the 20-day moving average (MA) of 23.26, above the 50-day MA of 26.12, and above the 200-day MA of 24.76, indicating a bearish trend. The MACD of -1.70 indicates Positive momentum. The RSI at 27.51 is Positive, neither overbought nor oversold. The STOCH value of 14.60 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for RCUS.
Arcus Biosciences Risk Analysis
Arcus Biosciences disclosed 61 risk factors in its most recent earnings report. Arcus Biosciences reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Arcus Biosciences Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
57 Neutral | $1.87B | -11.60 | -28.66% | ― | -28.56% | 10.25% | |
57 Neutral | $2.77B | 10.10 | 49.34% | ― | 738.76% | ― | |
54 Neutral | $4.78B | -10.38 | -24.39% | ― | -64.80% | 12.20% | |
54 Neutral | $1.60B | -171.82 | -2.35% | ― | 20.19% | ― | |
52 Neutral | $3.73B | -38.54 | -8.70% | ― | 59.59% | 71.96% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | $2.36B | -4.72 | -87.98% | ― | -55.34% | -23.18% |
* Healthcare Sector Average
RCUS
Arcus Biosciences
18.54
-0.06
-0.32%
XNCR
Xencor
25.18
10.91
76.45%
CRSP
Crispr Therapeutics AG
49.39
-16.33
-24.85%
LEGN
Legend Biotech
19.27
-12.85
-40.01%
NRIX
Nurix Therapeutics
25.34
13.36
111.52%
IMCR
Immunocore Holdings
30.98
-2.48
-7.41%
Arcus Biosciences Corporate Events
Business Operations and StrategyPrivate Placements and Financing
Arcus Biosciences Completes $269 Million Common Stock Offering
Positive
Oct 23, 2026
On October 21, 2026, Arcus Biosciences, Inc. entered into an underwriting agreement with a syndicate of investment banks for a public offering of its common stock at a price of $17.50 per share, including an option for underwriters to purchase add...
Business Operations and StrategyProduct-Related Announcements
Arcus Biosciences unveils promising kidney cancer data
Positive
Oct 20, 2026
On October 20, 2026, Arcus Biosciences reported new data from its ARC-20 platform study of casdatifan-based regimens in clear cell renal cell carcinoma, covering first-, second- and late-line settings as of a September 4, 2026 cutoff. First-line T...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.