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Penumbra Inc. (PEN)
NYSE:PEN
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Penumbra (PEN) AI Stock Analysis

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PEN

Penumbra

(NYSE:PEN)

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Outperform 70 (OpenAI - 5.2)
Rating:70Outperform
Price Target:
$352.00
▲(10.44% Upside)
Action:Upgraded
Date:07/31/26
The score is driven primarily by strong financial performance (growth, improved margins, solid recent cash generation, and low leverage). Offsetting factors include a high valuation (P/E 73.06) and only mixed technical signals based on available moving averages. Corporate events are supportive due to shareholder approval of the Boston Scientific merger, but closing conditions remain.
Positive Factors
Revenue and Margin Growth
Sustained revenue expansion alongside recovered profitability indicates strong demand for Penumbra’s interventional devices. Its consistently high gross margin and improved operating margin provide capacity to fund innovation, commercialization and future growth.
Negative Factors
Earnings Volatility
The uneven earnings path shows that profitability is not fully stable across periods. Future cost pressure, commercialization spending or operating disruptions could again reduce margins, making results less predictable despite the recent recovery.
Read all positive and negative factors
Positive Factors
Negative Factors
Revenue and Margin Growth
Sustained revenue expansion alongside recovered profitability indicates strong demand for Penumbra’s interventional devices. Its consistently high gross margin and improved operating margin provide capacity to fund innovation, commercialization and future growth.
Read all positive factors

Penumbra (PEN) vs. SPDR S&P 500 ETF (SPY)

Penumbra Business Overview & Revenue Model

Company Description
Penumbra, Inc., together with its subsidiaries, designs, develops, manufactures, and markets medical devices in the United States and internationally. It offers computer-assisted vacuum thrombectomy; peripheral thrombectomy products, including the...
How the Company Makes Money
Penumbra primarily makes money by selling medical devices used in interventional procedures, with revenue largely driven by per-procedure disposable products (e.g., aspiration/thrombectomy catheters and related single-use components) that hospital...

Penumbra Earnings Call Summary

Earnings Call Date:Nov 05, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Nov 04, 2026
Earnings Call Sentiment Positive
The earnings call reflected a strong performance with significant revenue growth, particularly in the VTE and embolization segments, and positive developments in clinical trials, offset by some challenges in international markets and increased operational costs.
Positive Updates
Strong Revenue Growth
Total revenue reached $354.7 million, showing a year-over-year growth of 17.8% on a reported basis and 16.9% in constant currency. U.S. revenue grew by 21.5% to $275 million.
Negative Updates
China Growth Headwinds
Continued growth headwinds in China, though international revenue still increased by 6.6% year-over-year.
Read all updates
Q3-2025 Updates
Negative
Strong Revenue Growth
Total revenue reached $354.7 million, showing a year-over-year growth of 17.8% on a reported basis and 16.9% in constant currency. U.S. revenue grew by 21.5% to $275 million.
Read all positive updates
Company Guidance
During Penumbra's third-quarter 2025 conference call, the company reported total revenue of $354.7 million, marking a 17.8% year-over-year growth on a reported basis and 16.9% in constant currency. U.S. revenue reached $275 million, a 21.5% increase compared to the previous year. Specifically, U.S. thrombectomy sales rose by 18.5% to $192 million, while the VTE franchise led corporate growth with a 34% rise. Meanwhile, U.S. embolization and access revenue soared by 29.2% to $83 million. International revenue was $79.7 million, reflecting a 6.6% year-over-year increase. The company's gross margin expanded by 130 basis points to 67.8%, and operating income stood at $48.8 million, or 13.8% of revenue. Penumbra's guidance for the year was raised to $1.375 billion to $1.380 billion in revenue, with anticipated U.S. thrombectomy growth of 20% to 21% for 2025. The company remains focused on expanding its market presence, particularly through innovative products like the Lightning Bolt 16 and Lightning Flash 3.0, which have received FDA clearance.

Penumbra Financial Statement Overview

Summary
Strong recent fundamentals: material revenue expansion into 2025/TTM, solid profitability recovery (TTM EBIT ~14% and net margin ~12%), and robust operating/free cash flow in 2025/TTM with modest leverage (TTM debt-to-equity ~0.15). Main risk is historical volatility (2022 losses/cash burn and a sharp 2024 profitability dip) despite the recent rebound.
Income Statement
84
Very Positive
Balance Sheet
78
Positive
Cash Flow
82
Very Positive
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue1.50B1.40B1.19B1.06B847.13M747.59M
Gross Profit1.02B942.44M755.00M682.64M535.21M475.38M
EBITDA222.27M223.91M45.99M108.65M29.96M7.84M
Net Income160.59M177.69M14.01M90.95M-2.00M5.28M
Balance Sheet
Total Assets1.97B1.83B1.53B1.56B1.37B1.24B
Cash, Cash Equivalents and Short-Term Investments658.79M544.82M340.13M289.19M188.03M254.88M
Total Debt212.71M219.70M223.39M234.34M235.77M173.55M
Total Liabilities443.96M398.92M382.25M377.36M372.03M290.32M
Stockholders Equity1.53B1.43B1.15B1.18B998.86M953.93M
Cash Flow
Free Cash Flow215.91M174.93M147.30M82.12M-74.96M-11.68M
Operating Cash Flow277.80M238.66M168.48M97.33M-55.66M9.50M
Investing Cash Flow-510.23M-404.59M77.62M-16.08M54.79M-21.73M
Financing Cash Flow16.13M26.53M-87.01M16.20M11.62M836.00K

Penumbra Risk Analysis

Penumbra disclosed 64 risk factors in its most recent earnings report. Penumbra reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Penumbra Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
81
Outperform
$11.86B21.5811.59%19.74%51.10%
70
Outperform
$12.87B79.1611.09%17.55%7.09%
69
Neutral
$4.45B22.6715.41%12.39%
62
Neutral
$4.11B-297.63-8.97%25.58%85.38%
61
Neutral
$11.18B-56.89-27.07%41.55%-96.75%
54
Neutral
$1.25B-10.69-30.62%22.69%-25.05%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PEN
Penumbra
323.76
72.39
28.80%
GMED
Globus Medical
85.67
25.17
41.60%
GKOS
Glaukos
184.89
95.10
105.91%
LIVN
LivaNova
78.21
25.35
47.96%
IRTC
Irhythm Technologies
127.98
-38.70
-23.22%
PRCT
PROCEPT BioRobotics
20.73
-18.62
-47.32%

Penumbra Corporate Events

Executive/Board ChangesShareholder Meetings
Penumbra Shareholders Back Directors, Auditor and Pay Policies
Positive
Jun 22, 2026
Penumbra, Inc. held its Annual Meeting of Stockholders on June 18, 2026, with 29,260,683 of 39,331,425 eligible shares represented in person or by proxy. Stockholders elected Arani Bose, M.D., Bridget O’Rourke and Surbhi Sarna as Class II di...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 31, 2026