Moleculin Biotech (MBRX) AI Stock Analysis

• Market Cap: $13.28M
• Dividend Yield: N/A
• Average Volume (3M): 368.12K
• Price to Earnings (P/E): ―
• Beta (1Y): 2.09
• Revenue Growth: N/A
• EPS Growth: 52.82%
• Country: US
• Employees: 17
• Sector: Healthcare
• Sector Strength: 41
• Industry: Biotechnology
• EPS (TTM): -0.69
• Shares Outstanding: 14,127,494
• 10 Day Avg. Volume: 488,493
• 30 Day Avg. Volume: 368,116
• PEG Ratio: -0.02
• Price to Book (P/B): 209.12
• Price to Sales (P/S): 0.00
• P/FCF Ratio: -0.61
• Enterprise Value/Market Cap: 0.44
• Enterprise Value/Revenue: 6.28
• Enterprise Value/Gross Profit: 184.06
• Enterprise Value/Ebitda: -0.05
• 1Y Price Target: $10.67
• Price Target Upside: 1035.11% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 3

Moleculin Biotech's stock score reflects a high-risk financial position with no revenue and growing losses typical of early-stage biotech firms. Positive developments in clinical trials and a solid financial runway provide potential upside, but significant risks remain due to financial instability, high trial costs, and future funding needs. Technical indicators suggest bearish momentum, and the valuation is unattractive due to the absence of earnings.

Positive Factors

Clinical Trials

With MIRACLE now enrolling and dosing patients in the US, clearance for EU sites to start up and positioned for unblinded interim data, Moleculin should be positioned to unlock value on the data readout.

Financial Performance

The company was able to successfully complete two transactions under more favorable terms, including a warrant inducement transaction and a registered direct offering, which combined raised $9.3M.

Regulatory Approvals

Annamycin currently has Fast Track and Orphan Drug Designation from the FDA for the treatment of R/R AML, increasing potential to accelerate its timeline for approval.

Negative Factors

Capital Raising

The company is seeking to raise capital through the sale of common stock and warrants, which could lead to significant share dilution and affect the company's ability to operate.

Financial Stability

The company's cash reserves are low with high quarterly cash burn, necessitating immediate capital raising efforts.

Stock Rating

The downgrade to Hold from Buy is influenced by potential significant dilution from ongoing capital-raising efforts.

Moleculin Biotech Business Overview & Revenue Model

Company Description

Moleculin Biotech, Inc., a clinical-stage pharmaceutical company, focuses on the development of drug candidates for the treatment of highly resistant tumors and viruses. Its lead drug candidate is Annamycin that is in Phase 1/2 studies for the treatment of relapsed or refractory acute myeloid leukemia (AML) and cancers metastasized to the lungs. The company's flagship immune/transcription modulator is WP1066, which is in Phase I clinical trial for the treatment of brain tumors and pediatric brain tumors, as well as pancreatic cancer and other malignancies. It also develops WP1220, an analog of WP1066 for the topical treatment of cutaneous T-cell lymphoma; and WP1122 to treat glioblastoma multiforme and COVID-19. The company has partnership and collaboration agreements with MD Anderson; Animal Life Sciences, LLC; and WPD Pharmaceuticals Sp z.o.o. Moleculin Biotech, Inc. was incorporated in 2015 and is headquartered in Houston, Texas.

How the Company Makes Money

Moleculin Biotech primarily makes money through the development and potential commercialization of its oncology drug candidates. The company seeks to generate revenue by advancing its drug candidates through clinical trials and securing regulatory approvals. Revenue streams may include licensing agreements, collaborations with larger pharmaceutical companies, and potential sales of approved drugs. Additionally, Moleculin may receive milestone payments and royalties from partners involved in the commercialization of its drug candidates. The company's financial success heavily relies on its ability to successfully demonstrate the efficacy and safety of its drug candidates in clinical trials and to navigate the regulatory landscape for drug approvals.

Moleculin Biotech Financial Statement Overview

Summary

Moleculin Biotech is in a high-risk financial position typical for early-stage biotech firms. The absence of revenue and increasing losses emphasize the risky nature of its operations. Despite low leverage, the declining equity and assets raise concerns about sustainability. Continuous reliance on external funding underscores the need for successful product development to generate future revenues.

Income Statement

Moleculin Biotech has consistently reported zero revenue over the years, reflecting its pre-commercial stage typical in the biotech industry. The net income has been negative, with increasing losses each year, indicating growing expenses without revenue generation. This suggests a high-risk profile in terms of profitability and revenue generation.

Balance Sheet

The company's debt-to-equity ratio remains low due to minimal debt levels, which is positive for financial stability. However, the equity has been declining over the years, reflecting continuous operational losses. The equity ratio suggests a relatively moderate reliance on equity financing, but the declining trend in total assets highlights potential liquidity concerns.

Cash Flow

Moleculin Biotech has been consistently generating negative free cash flow, with no signs of improvement, reflecting its high cash burn rate common in biotech firms. The operating cash flow to net income ratio is high due to substantial operating losses. Financing cash flows have been positive, indicating reliance on external funding for operations.

Breakdown
TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement		Total Revenue
63.00K	0.00	0.00	0.00	0.00	0.00
	Gross Profit
32.00K	0.00	-127.00K	-222.00K	-260.00K	-285.00K
	EBIT
-25.91M	-26.64M	-29.63M	-30.64M	-22.97M	-19.74M
	EBITDA
-25.78M	-21.64M	-29.50M	-30.51M	-22.80M	-19.54M
	Net Income Common Stockholders
-23.23M	-21.76M	-29.77M	-27.41M	-8.86M	-15.00M
Balance Sheet		Cash, Cash Equivalents and Short-Term Investments
23.55M	4.28M	23.55M	43.15M	70.90M	15.17M
	Total Assets
38.22M	16.93M	38.22M	57.42M	84.09M	29.03M
	Total Debt
574.00K	478.00K	574.00K	451.00K	159.00K	277.00K
	Net Debt
-22.98M	-3.80M	-22.98M	-42.69M	-70.74M	-14.90M
	Total Liabilities
12.14M	10.95M	12.14M	5.23M	5.10M	11.27M
	Stockholders Equity
26.07M	5.98M	26.07M	52.19M	78.99M	17.76M
Cash Flow		Free Cash Flow
-21.72M	-23.88M	-24.23M	-27.71M	-18.97M	-18.15M
	Operating Cash Flow
-21.71M	-23.86M	-24.10M	-27.64M	-18.95M	-17.77M
	Investing Cash Flow
-13.00K	-13.00K	-124.00K	-67.00K	-19.00K	-374.00K
	Financing Cash Flow
12.63M	4.63M	4.65M	-23.00K	74.72M	22.55M

Moleculin Biotech Technical Analysis

• Technical Analysis Sentiment: Negative
• Last Price: 0.94
• 50DMA: Negative
• 100DMA: Negative
• 200DMA: Negative
• MACD: Positive
• RSI: Neutral
• STOCH: Positive

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For MBRX, the sentiment is Negative. The current price of 0.94 is below the 20-day moving average (MA) of 1.02, below the 50-day MA of 1.00, and below the 200-day MA of 1.86, indicating a bearish trend. The MACD of >-0.01 indicates Positive momentum. The RSI at 44.68 is Neutral, neither overbought nor oversold. The STOCH value of 18.25 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for MBRX.

Moleculin Biotech Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
Sector *	52 Neutral	$5.15B	3.02	-44.64%	2.83%	16.44%	-0.47%
SYBX	45 Neutral	$12.63M	9.22	11.34%	―	-99.76%	76.96%
MBRX	44 Neutral	$13.28M	―	-214.79%	―	―	52.82%
MRKR	44 Neutral	$12.56M	―	-97.30%	―	-3.23%	38.05%
PHIO	42 Neutral	$8.83M	―	-76.12%	―	―	81.71%
IMNN	41 Neutral	$7.07M	―	-397.54%	―	―	24.16%
INAB	34 Underperform	$11.68M	―	-174.66%	―	―	38.53%

Moleculin Biotech Corporate Events

Moleculin Biotech Unveils Promising Annamycin Data at AACR

On April 28, 2025, Moleculin Biotech presented new pre-clinical data for their drug Annamycin at the AACR Annual Meeting, highlighting its potential to expand into markets such as pancreatic cancer. The research suggests Annamycin can work synergistically with various FDA-approved anticancer drugs, potentially enhancing its clinical applications and attractiveness to future partners, which could significantly impact the company’s market positioning and stakeholder interest.

Spark’s Take on MBRX Stock

According to Spark, TipRanks’ AI Analyst, MBRX is a Underperform.

Moleculin Biotech’s stock score reflects the company’s high-risk financial position, characterized by no revenue and growing losses typical of early-stage biotech firms. The technical analysis signals bearish momentum, while the valuation highlights financial instability. Positive clinical trial developments and a solid cash position provide potential upside, but significant risks remain, especially regarding high trial costs and future funding needs.

To see Spark’s full report on MBRX stock, click here.

Moleculin Biotech Releases Corporate Presentation Online

On April 21, 2025, Moleculin Biotech, Inc. made a corporate presentation available on its website. The presentation is part of a Current Report on Form 8-K but is not filed under the Securities Exchange Act of 1934 or the Securities Act of 1933.

Spark’s Take on MBRX Stock

According to Spark, TipRanks’ AI Analyst, MBRX is a Underperform.

Moleculin Biotech faces significant financial challenges with no revenue and high cash burn, typical of early-stage biotech firms. Bearish technical indicators and negative valuation metrics reflect low investor confidence. However, positive developments in clinical trials and a solid financial runway offer potential upside if milestones are met. The overall risk remains high due to financial instability and the high costs associated with ongoing trials.

To see Spark’s full report on MBRX stock, click here.

Moleculin Biotech’s Annamycin Highlighted at AACR 2025

On April 17, 2025, Moleculin Biotech announced that their abstract on Annamycin, a next-generation anthracycline, was selected for a poster presentation at the AACR Annual Meeting 2025. This recognition highlights the potential of Annamycin in cancer treatment and strengthens Moleculin’s position in the pharmaceutical industry, particularly in developing innovative cancer therapies.

Spark’s Take on MBRX Stock

According to Spark, TipRanks’ AI Analyst, MBRX is a Underperform.

Moleculin Biotech faces significant financial challenges typical of early-stage biotech firms, with no revenue and increasing losses. The stock is under bearish technical indicators, reflecting low investor confidence. However, positive developments in clinical trials and a solid financial runway offer potential upside if milestones are met. The overall risk remains high due to financial instability and the high costs associated with ongoing trials.

To see Spark’s full report on MBRX stock, click here.

Moleculin Biotech Begins Phase 3 MIRACLE Trial Dosing

On April 1, 2025, Moleculin Biotech announced the commencement of dosing for the first patient in its Phase 3 MIRACLE trial, which evaluates Annamycin combined with Cytarabine for treating relapsed or refractory acute myeloid leukemia (R/R AML). This trial marks a significant milestone for the company and the AML community, with initial data expected in the second half of 2025. The trial’s adaptive design and global scope aim to accelerate Annamycin’s development towards approval, potentially impacting Moleculin’s market positioning and providing valuable insights for stakeholders.

Moleculin Biotech Shares Corporate Presentation Update

On March 24, 2025, Moleculin Biotech, Inc. utilized a corporate presentation for its website, which was detailed in a Current Report on Form 8-K. The presentation, noted as Exhibit 99.1, was shared for informational purposes and not intended for filing under the Securities Exchange Act of 1934 or the Securities Act of 1933.

Moleculin Biotech Gets FDA Nod for Phase 3 Trial

On February 13, 2025, Moleculin Biotech announced receiving FDA feedback that allows a reduced size for its Phase 3 trial protocol evaluating Annamycin combined with Cytarabine for treating relapsed or refractory AML. This trial, named MIRACLE, will be conducted globally, including in the US, Europe, and the Middle East, and aims to accelerate the approval timeline for this potentially groundbreaking non-cardiotoxic anthracycline. The feedback enables quicker site openings and recruitment, with implications for significantly impacting AML treatment and eliminating cardiotoxic risks in cancer therapies.

Moleculin Biotech Gains European Approval for Phase 3 Trial

On February 11, 2025, Moleculin Biotech announced receiving regulatory approval in Europe to start recruiting for its Phase 3 MIRACLE trial, evaluating Annamycin combined with Cytarabine for treating relapsed or refractory acute myeloid leukemia. The trial will include sites in the US, Europe, and the Middle East. The announcement signifies a crucial step in advancing their pivotal clinical trial, aiming for unblinded preliminary data from the first 45 subjects in the second half of 2025, potentially enhancing their market position in cancer therapeutics.