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Chiome Bioscience Inc. (4583) Price & Analysis
4583 Stock Chart & Stats
- Day’s Range
- JPY 88.00 - JPY 93.00
- 52-Week Range
- JPY 65.00 - JPY 136.00
- Previous Close
- JPY 92.00
- Volume
- 5.12M
- Average Volume (3M)
- 803.93K
- Market Cap
- JPY 7.29B
- Enterprise Value
- JPY 4.67B
- Total Cash (Recent Filing)
- JPY 1.37B
- Total Debt (Recent Filing)
- JPY 67.50M
- Price to Earnings (P/E)
- ―
- Beta
- 0.58
- Next Earnings
- Nov 10, 2026
- EPS Estimate
- N/A
- Next Dividend Ex-Date
- N/A
- Dividend Yield
- N/A
Bulls Say, Bears Say
Bulls Say
Modest Leverage
Modest leverage gives Chiome greater financial flexibility than a highly indebted biotechnology company. Lower debt obligations can reduce pressure on cash resources and preserve room for research investment, although this benefit depends on containing ongoing losses and cash use.
Solid Gross Margin
A consistently solid gross margin indicates that the company’s underlying activities can retain a meaningful share of revenue before operating expenses. If revenue stabilizes and research spending becomes more productive, this margin base could support eventual operating leverage.
Historical Loss Narrowing
The earlier narrowing of losses shows that Chiome has demonstrated some capacity to improve its cost and earnings profile from prior levels. This is not yet a sustained turnaround, but it provides evidence that profitability may improve if development progress and revenue quality strengthen.
Bears Say
Revenue Decline And Volatility
Volatile and declining revenue makes it harder for Chiome to build a dependable funding base for oncology research and development. The 2025 contraction after two years of growth suggests that commercial scale remains unproven and that future investment may rely on uncertain revenue recovery.
Deep Unprofitability
Very large losses relative to revenue indicate that Chiome has not yet converted its biotechnology research activities into an economically sustainable operation. Persistent unprofitability can erode equity over time and limits the company’s ability to fund development internally.
Persistent Cash Burn
Ongoing negative operating and free cash flow shows that accounting losses are translating into real cash outflows rather than being mainly non-cash. If this pattern persists, Chiome will face continuing funding pressure while it finances research and development activities.
Chiome Bioscience Inc. News
Chiome Bioscience’s Innovative Phase I Study on CBA-1535: A Potential Game-Changer in Cancer Treatment
Chiome Bioscience Inc. (($JP:4583)) announced an update on their ongoing clinical study. Chiome Bioscience Inc. is conducting a Phase I clinical study titled ‘A Phase I Study to Assess the
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Company Description
Chiome Bioscience Inc.
Chiome Bioscience Inc. engages in the research and development of drug discovery technology platforms worldwide. It operates in two segments, Drug Discovery Business and Drug Discovery Support Business. The company offers ADLib System, a technology for generating monoclonal antibodies which is used to generate antibodies for drug discovery research; and Human ADLib System, which converts chicken antibody genes to humanized antibodies. It also provides protein expression and purification services; stable cell line development services for recombinant protein and antibody production; and antibody generation services using the ADLib system. In addition, the company's product pipeline under Phase 1 trial comprises ADCT-701, an anti-dlk1 antibody for treating liver cancer; CBA-1205, an afucosylated anti-dlk1 antibody for liver cancer, lung cancer, and neuroblastoma; and CBA-1535, an anti 5T4/WAIF1 antibody for malignant mesothelioma, small cell lung cancer, non-small cell lung cancer, and triple negative breast cancer (TNBC). Further, its product pipeline under preclinical study includes PCDC, an anti- CDCP1 antibody for lung, colorectal, pancreatic, breast, and ovarian tumors; PTRY, an antibody 5T4/CD3/PD-L1 for treating malignant mesothelioma, small cell lung cancer, non-small cell lung cancer, and TNBC; BMAA, an anti-semphorin3a antibody for treating renal and other diseases; LIV-2008/2008b, an anti-TROP-2 antibody for the treatment of TNBC, lung cancer, and colorectal cancer; PFKR, an anti-CX3CR1 antibody for secondary progressive multiple sclerosis; and PXLR, an anti-CXCL1/2/3/5 antibody for the treatment of gastric, breast, and ovarian tumors. Chiome Bioscience Inc. was incorporated in 2005 and is headquartered in Tokyo, Japan.
- Sector
- General
- Industry
- Biotechnology
- CEO
- Masamichi Koike
- Employees
- 49
- Website
- www.chiome.co.jp
- Address
- Sumitomo Fudosan Nishi-shinjuku Bldg.No.6, Tokyo, TY, 151-0071, JP
Chiome Bioscience Inc. (4583) Earnings & Revenues
Technical Analysis
Overall Consensus
| Indicator | Bullish | Neutral | Bearish |
|---|---|---|---|
| Overall Consensus | 3 | 6 | 13 |
| Technical Analysis | 2 | 6 | 2 |
| Moving Averages | 1 | 0 | 11 |








