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ACADIA Pharmaceuticals Inc. (ACAD)
NASDAQ:ACAD
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ACADIA Pharmaceuticals (ACAD) AI Stock Analysis

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ACAD

ACADIA Pharmaceuticals

(NASDAQ:ACAD)

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Outperform 79 (OpenAI - 5.2)
Rating:79Outperform
Price Target:
$31.00
▲(24.80% Upside)
Action:Reiterated
Date:08/05/26
ACAD scores well primarily on strengthened financial fundamentals (profitability inflection and a conservative, low-debt balance sheet), supported by positive technical momentum (price above major moving averages and positive MACD). Earnings-call takeaways further help due to raised DAYBUE guidance and multiple near-term catalysts, while the score is tempered by cash-flow variability, elevated gross-to-net, and higher operating spend that could pressure margins.
Positive Factors
Conservative balance sheet
Very low leverage and materially higher equity provide durable financial flexibility to fund commercialization, pipeline programs and BD without near-term refinancing risk. This balance-sheet strength supports capital allocation optionality through 2–6 months and cushions execution hiccups.
Negative Factors
Cash-flow variability
Free cash flow generation is positive but less consistent: a recent ~31% step-down in FCF versus prior periods signals variability in cash conversion. That volatility can constrain discretionary investments or require conservatism in reinvestment and BD planning over the next several quarters.
Read all positive and negative factors
Positive Factors
Negative Factors
Conservative balance sheet
Very low leverage and materially higher equity provide durable financial flexibility to fund commercialization, pipeline programs and BD without near-term refinancing risk. This balance-sheet strength supports capital allocation optionality through 2–6 months and cushions execution hiccups.
Read all positive factors

ACADIA Pharmaceuticals Key Performance Indicators (KPIs)

Any
Any
Revenue by Product
Revenue by Product
Shows earnings from individual products, highlighting which offerings drive growth and which may need strategic adjustments. This helps assess product portfolio strength and market positioning.
Chart InsightsDAYBUE has emerged as the primary growth driver—its rapid post‑launch ramp (including early STIX uptake) is materially shifting the revenue mix while NUPLAZID remains a durable, steadily growing franchise but is more susceptible to quarter-to-quarter refill timing noise. Management’s 30% sales‑force expansion and H2‑loaded guidance imply the company is deliberately investing to accelerate DAYBUE adoption, but high gross‑to‑net adjustments and sharply higher SG&A create near‑term margin pressure; sustained STIX scale and execution on upcoming readouts will determine whether upside to 2028 targets is realized or if investment risk persists.
Data provided by:The Fly

ACADIA Pharmaceuticals (ACAD) vs. SPDR S&P 500 ETF (SPY)

ACADIA Pharmaceuticals Business Overview & Revenue Model

Company Description
ACADIA Pharmaceuticals Inc. operates as a biopharmaceutical company, primarily dedicated to discovering, developing, and commercializing small molecule therapeutics. Their core focus lies in addressing critical unmet medical needs within the realm...
How the Company Makes Money
ACADIA makes money primarily through product sales of NUPLAZID (pimavanserin). Revenue is generated by selling the drug into the U.S. pharmaceutical distribution channel (e.g., wholesalers/specialty pharmacies) and ultimately to patients via presc...

ACADIA Pharmaceuticals Earnings Call Summary

Earnings Call Date:Aug 04, 2026
(Q2-2026)
|
% Change Since: |
Next Earnings Date:Nov 11, 2026
Earnings Call Sentiment Positive
The call conveyed strong commercial momentum and clear near-term catalysts: robust Q2 results (total revenues +17%), pronounced DAYBUE STIX uptake (DAYBUE +30% YoY), healthy NUPLAZID growth (+10% YoY) with new prescriptions up 20%, a positive CHMP opinion for trofinetide in Europe, and significant pipeline progress (remlifanserin Phase II enrollment complete, Fast Track designation, top-line data expected Sep–Oct 2026). Offsetting factors include rising SG&A, sizable gross‑to‑net adjustments (~24%), a lowered R&D spend guidance due to a shifted BD milestone, reimbursement and pricing uncertainties in Europe, and dependency on upcoming pivotal readouts (creating execution/timing risk). Overall, the positives — strong sales, upgraded DAYBUE guidance, regulatory wins and a deepening pipeline with imminent binary catalysts — outweigh the operational and timing risks presented.
Positive Updates
Strong Q2 Financial Performance
Total revenues of $308 million in Q2 2026, representing +17% year-over-year on an adjusted basis; company now guiding full-year 2026 revenues of $1.24 billion to $1.30 billion.
Negative Updates
Rising Operating Costs
SG&A expenses increased to $160 million in Q2 from $134 million a year ago (+~19%), driven by expanded field forces and higher marketing investments; R&D rose to $82 million from $78 million (+~5%).
Read all updates
Q2-2026 Updates
Negative
Strong Q2 Financial Performance
Total revenues of $308 million in Q2 2026, representing +17% year-over-year on an adjusted basis; company now guiding full-year 2026 revenues of $1.24 billion to $1.30 billion.
Read all positive updates
Company Guidance
ACADIA raised its 2026 DAYBUE guidance to $480–$510M (from $460–$490) while keeping NUPLAZID at $760–$790M, implying total 2026 revenue of $1.24–$1.30B; Q2 results included total revenues of $308M (+17% adjusted YoY), DAYBUE net sales $125M (+30% YoY; ~27% of the increase from volume; ~40% of U.S. DAYBUE patients on STIX by quarter‑end and strong June STIX referral momentum), NUPLAZID net sales $183M (+10% adjusted YoY; 8% volume growth; new patient prescriptions +20% YoY and >12,000 priority HCPs reached since February), Q2 gross‑to‑net of 24.4% for DAYBUE and 23.9% for NUPLAZID (DAYBUE FY gross‑to‑net now guided to 23–25%), operating spend highlights of R&D $82M and SG&A $160M in Q2 with R&D guidance lowered to $355–$380M (from $385–$410M) due to a shifted BD milestone, cash of $956M, and pipeline timing/guidance that includes remlifanserin Phase II top‑line in Sept–Oct (Phase II enrollment 363; 80% powered to a 0.4 effect size; peak sales est. ~$4B, ~60% ADP/40% LBD), trofinetide Japan readout Sept–Nov and expected initial EU commercial sales/Q4 pending EC decision after a positive CHMP opinion, plus longer‑term ambitions of $700M DAYBUE and ~$1B NUPLAZID in 2028.

ACADIA Pharmaceuticals Financial Statement Overview

Summary
Strong profitability inflection with revenue scaling to ~$1.14B TTM and robust TTM net income (~$380M; ~33% net margin). Balance sheet is a major strength with very low leverage (debt-to-equity ~0.04–0.07) and rising equity, supporting resilience. Main offset is cash-flow variability and a recent step-down in free cash flow (TTM FCF down ~31%), plus some margin softening versus prior highs.
Income Statement
78
Positive
Balance Sheet
86
Very Positive
Cash Flow
69
Positive
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue1.14B1.07B957.80M726.44M517.24M484.14M
Gross Profit1.04B982.51M875.96M680.71M507.07M465.00M
EBITDA116.12M150.66M100.16M-45.48M-211.42M-164.18M
Net Income380.48M391.00M226.45M-61.29M-215.97M-167.87M
Balance Sheet
Total Assets1.74B1.56B1.19B748.96M587.81M700.12M
Cash, Cash Equivalents and Short-Term Investments956.47M819.69M755.99M438.87M416.82M520.71M
Total Debt73.85M52.19M51.99M57.20M62.00M64.43M
Total Liabilities436.29M336.81M454.96M317.20M187.40M159.23M
Stockholders Equity1.31B1.23B732.79M431.75M400.41M540.89M
Cash Flow
Free Cash Flow174.39M105.15M157.20M-23.35M-114.03M-126.78M
Operating Cash Flow194.30M109.84M157.72M16.70M-114.03M-125.66M
Investing Cash Flow-11.19M-302.56M-30.54M32.00M73.24M-71.10M
Financing Cash Flow51.05M49.88M6.84M25.13M8.20M18.16M

ACADIA Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Positive
Last Price24.84
Price Trends
50DMA
25.69
Positive
100DMA
23.75
Positive
200DMA
24.12
Positive
Market Momentum
MACD
1.17
Negative
RSI
60.23
Neutral
STOCH
69.92
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ACAD, the sentiment is Positive. The current price of 24.84 is below the 20-day moving average (MA) of 27.88, below the 50-day MA of 25.69, and above the 200-day MA of 24.12, indicating a bullish trend. The MACD of 1.17 indicates Negative momentum. The RSI at 60.23 is Neutral, neither overbought nor oversold. The STOCH value of 69.92 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ACAD.

ACADIA Pharmaceuticals Risk Analysis

ACADIA Pharmaceuticals disclosed 55 risk factors in its most recent earnings report. ACADIA Pharmaceuticals reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

ACADIA Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
79
Outperform
$5.21B12.9132.39%11.75%68.42%
76
Outperform
$10.16B40.7519.34%22.63%62.39%
58
Neutral
$12.63B-39.05-60.54%16.85%-80.39%
54
Neutral
$1.42B-4.12-82.68%-37.48%
53
Neutral
$6.15B-143.9221.72%-42.84%-106.21%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ACAD
ACADIA Pharmaceuticals
29.04
3.30
12.82%
ARWR
Arrowhead Pharmaceuticals
87.47
66.14
310.08%
PTCT
PTC Therapeutics
70.52
19.95
39.45%
KRYS
Krystal Biotech
337.02
186.53
123.96%
MLTX
MoonLake Immunotherapeutics
15.87
-40.02
-71.60%

ACADIA Pharmaceuticals Corporate Events

Business Operations and StrategyExecutive/Board ChangesShareholder Meetings
Acadia Shareholders Approve Directors, Executive Pay and Equity Plan
Positive
May 29, 2026
Acadia Pharmaceuticals Inc. held its 2026 Annual Meeting of Stockholders on May 29, 2026, where shareholders elected three Class I directors, James M. Daly, Edmund P. Harrigan, M.D., and Adora Ndu, Pharm.D., J.D., to serve until the 2029 annual me...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 05, 2026