BRISBANE, Calif., March 14, 2023 (GLOBE NEWSWIRE) — Tempest Therapeutics, Inc. (Nasdaq: TPST), a clinical-stage oncology company developing first-in-class1 therapeutics that combine both targeted and immune-mediated mechanisms, today announced that two abstracts have been accepted for poster presentation at the 2023 American Association for Cancer Research (AACR) Annual Meeting taking place April 14-19, 2023 in Orlando, FL. The presentations will highlight biomarker data from the Phase 1 trial of TPST-1120, an oral selective PPAR⍺ antagonist and preclinical data from TREX1 inhibitor, a tumor-selective STING pathway activator.
Poster presentation details:
| Title: | Lipid and immune-based biomarkers associated with clinical response to TPST-1120: A small molecule antagonist of peroxisome-proliferator activated receptor-alpha |
| Session Category: | Clinical Research Excluding Trials |
| Session Title: | Biomarkers of Therapeutic Benefit 2 |
| Session Date & Time: | Monday, April 17, 2023 9:00 a.m. – 12:30 p.m. ET |
| Location: | Poster Section 39 |
| Abstract Number: | 2130 |
| Title: | Generation of novel potent human TREX1 inhibitors facilitated by crystallography |
| Session Category: | Experimental and Molecular Therapeutics |
| Session Title: | Novel Antitumor Agents 3 |
| Session Date & Time: | Monday, April 17, 2023 9:00 a.m. – 12:30 p.m. ET |
| Location: | Poster Section 17 |
| Abstract Number: | 1636 |
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1 If approved by the FDA
Abstracts are available for viewing via the AACR Online Itinerary Planner located here, https://www.abstractsonline.com/pp8/#!/10828.
About Tempest Therapeutics
Tempest Therapeutics is a clinical-stage oncology company advancing small molecules that combine both tumor-targeted and immune-mediated mechanisms with the potential to treat a wide range of tumors. The company has a diverse portfolio of novel programs ranging from early research to investigation in a randomized global study in first-line cancer patients. The company’s two novel clinical programs TPST-1120 and TPST-1495, target of PPARα and EP2/EP4, respectively, are advancing through trials designed to study the agents as monotherapies and in combination with other approved agents. Tempest is also developing an orally available inhibitor of TREX1, a target that controls activation of the cGAS/STING pathway. Tempest is headquartered in Brisbane, California. More information about Tempest can be found on the company’s website at www.tempesttx.com.
Investor Contacts:
Sylvia Wheeler
Wheelhouse Life Science Advisors
swheeler@wheelhouselsa.com
Aljanae Reynolds
Wheelhouse Life Science Advisors
areynolds@wheelhouselsa.com
