Sionna Therapeutics Advances Phase 1 Study for Cystic Fibrosis Treatment

Sionna Therapeutics, Inc. ((SION)) announced an update on their ongoing clinical study.

Sionna Therapeutics, Inc. (SION) is currently conducting a Phase 1 clinical study titled A Phase 1 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses and Multiple Ascending Doses of SION-451, and Multiple Dose Combinations of SION-451 and Complementary Modulators SION-2222 and SION-109 in Healthy Participants. The study aims to assess the safety, tolerability, and pharmacokinetics of these drug combinations in healthy individuals, which could have significant implications for treating Cystic Fibrosis (CF).

The study is testing the effects of SION-451, SION-2222, and SION-109, all administered orally. These drugs are designed to work together to potentially improve treatment outcomes for CF patients.

This is an interventional study with a randomized, parallel assignment model. It employs a quadruple masking approach, meaning that participants, care providers, investigators, and outcomes assessors are all blinded to the treatment allocations. The primary purpose of the study is treatment-focused.

The study began on June 4, 2025, with a recent update on September 2, 2025. These dates are crucial as they mark the progression and current status of the study, which is still recruiting participants.

For investors, the progress of this study could influence Sionna Therapeutics’ stock performance, as successful results could enhance the company’s market position in the CF treatment landscape. Competitors in the CF space may also be closely monitoring these developments.

The study is ongoing, and further details can be found on the ClinicalTrials portal.