Illumina ((ILMN)) has held its Q3 earnings call. Read on for the main highlights of the call.
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Illumina’s recent earnings call painted a picture of optimism and resilience, despite some challenges in specific markets. The company reported exceeding revenue and earnings expectations, driven by significant progress in clinical markets and the successful transition to NovaSeq X. However, hurdles remain in research markets and China, yet Illumina remains positive about its strategic initiatives and future growth prospects.
Revenue Exceeds Guidance
Illumina reported a total revenue of $1.08 billion, surpassing its guidance range. The non-GAAP operating margin stood at 24.5%, and the non-GAAP diluted EPS was $1.34, both exceeding expectations. This strong financial performance underscores the company’s robust operational execution.
Strong Performance in Clinical Markets
The clinical markets have been a primary growth driver for Illumina, with sequencing consumables revenue growing at a high single-digit rate year-over-year. This growth is supported by new assay approvals and increased demand for sequencing-intensive tests, highlighting the strength of Illumina’s clinical segment.
Successful NovaSeq X Transition
Illumina successfully placed more than 55 NovaSeq X instruments in the third quarter, surpassing its goal of 50-60 placements per quarter. The NovaSeq X accounted for 78% of volumes and 51% of revenue in Q3, marking a significant milestone in the company’s high-throughput transition.
Expansion in Multiomics
The company is expanding its multiomics portfolio with the launch of Illumina Protein Prep and the 5-base solution. Additionally, Illumina is progressing with the acquisition of SomaLogic, expected to close in 2026, which will further enhance its multiomics capabilities.
Increased Full-Year Outlook
Due to strong Q3 performance and resilience in clinical markets, Illumina has raised its full-year 2025 outlook. This adjustment reflects the company’s confidence in its ongoing strategic initiatives and market positioning.
Challenges in Research and Applied Markets
While there is stabilization in research demand, Illumina faces continued funding uncertainty and pricing dynamics that are impacting revenue. These challenges highlight the need for strategic adjustments to navigate the evolving market landscape.
Ongoing Challenges in China
Revenue in China was reported at $52 million, falling below expectations due to export restrictions. The company is still seeking a long-term resolution to these operational challenges in China, which remain a significant hurdle.
Gross Margin Impacted by Tariffs
Illumina’s non-GAAP gross margin was 69.2%, affected by tariffs that reduced gross margins by approximately 220 basis points. This impact underscores the external pressures the company faces in maintaining its profitability.
Forward-Looking Guidance
Looking ahead, Illumina anticipates continued momentum in its clinical segment and plans to expand into multiomics and enhance its services and software capabilities. The company expects a gradual recovery in research markets and remains committed to overcoming challenges in China.
In summary, Illumina’s earnings call reflects a company that is navigating challenges with strategic foresight and operational excellence. While there are hurdles in research markets and China, the overall sentiment remains positive, driven by strong performance in clinical markets and successful strategic initiatives.

