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XBI

SPDR S&P BIOTECH ETF (XBI)

Rating:59Neutral
Price Target:
$115.00
The SPDR S&P Biotech ETF (XBI) has a moderate overall rating, reflecting a mix of strengths and challenges among its holdings. United Therapeutics and Vertex Pharmaceuticals stand out as key contributors to the fund's performance due to their strong financial results, strategic initiatives, and bullish technical momentum. However, weaker holdings like Crispr Therapeutics and Revolution Medicines, which face profitability and valuation challenges, may have weighed on the ETF’s rating. A notable risk factor is the fund's concentration in the volatile biotech sector, which is inherently exposed to regulatory and market uncertainties.
Positive Factors
Strong Year-to-Date Performance
The ETF has delivered solid gains so far this year, indicating positive momentum in the biotech sector.
Low Expense Ratio
The fund charges a relatively low fee, making it cost-effective for investors compared to many other ETFs.
Top Holdings Showing Strength
Several of the largest positions, such as Ionis Pharmaceuticals and Insmed, have shown strong year-to-date performance.
Negative Factors
Sector Over-Concentration
The ETF is heavily focused on the healthcare sector, which limits diversification and increases exposure to industry-specific risks.
Geographic Concentration
With nearly all assets invested in U.S. companies, the fund lacks global diversification and is vulnerable to domestic market fluctuations.
Mixed Performance Among Top Holdings
Some key holdings, such as Vertex Pharmaceuticals and Exact Sciences, have shown weaker year-to-date performance, which could drag on overall returns.

XBI vs. SPDR S&P 500 ETF (SPY)

XBI Summary

The SPDR S&P Biotech ETF (XBI) is a fund that focuses on the biotechnology sector, part of the health care industry. It includes a mix of companies, from established names like Amgen and Vertex Pharmaceuticals to smaller, innovative firms working on cutting-edge medical advancements like gene editing and personalized medicine. This ETF offers a way to invest in the growth potential of biotech, a field known for driving transformative health care solutions. However, new investors should be aware that the biotech sector can be volatile, as stock prices often depend on the success of clinical trials and regulatory approvals.
How much will it cost me?The SPDR S&P Biotech ETF (XBI) has an expense ratio of 0.35%, meaning you’ll pay $3.50 per year for every $1,000 invested. This expense ratio is slightly higher than average because the fund is actively managed with an equal-weighted structure, which requires more frequent adjustments compared to passively managed ETFs.
What would affect this ETF?The SPDR S&P Biotech ETF (XBI) could benefit from advancements in biotechnology, such as breakthroughs in gene editing and personalized medicine, which drive innovation and growth in the sector. However, it may face challenges from regulatory hurdles, high research costs, and potential economic downturns that could impact funding and investor sentiment in the biotech industry.

XBI Top 10 Holdings

The SPDR S&P Biotech ETF (XBI) is a dynamic play on the U.S. biotechnology sector, showcasing a diverse mix of established players and emerging innovators. Recent performance has been buoyed by companies like Insmed and Ionis Pharmaceuticals, which are riding strong technical momentum and positive clinical trial results. Revolution Medicines is also showing promise with advancements in its pipeline, despite ongoing financial challenges. However, stalwarts like Amgen and Vertex Pharmaceuticals have been more subdued, with mixed signals and some short-term volatility. With nearly all its exposure in health care, this fund is a concentrated bet on biotech breakthroughs.
Name
Company Name
Weight %
Market Value
Market Cap
Yearly Gain
Overall Rating
Avidity Biosciences2.45%$167.57M$10.16B61.15%
54
Neutral
Revolution Medicines2.11%$144.50M$10.85B14.89%
52
Neutral
Crispr Therapeutics AG2.00%$136.75M$5.69B30.52%
54
Neutral
BridgeBio Pharma1.98%$135.41M$12.74B180.03%
55
Neutral
Regeneron1.92%$130.92M$68.61B-29.25%
79
Outperform
Exact Sciences1.88%$128.50M$11.88B-10.96%
63
Neutral
Ionis Pharmaceuticals1.87%$127.81M$11.46B83.09%
57
Neutral
Insmed1.84%$125.95M$35.29B137.50%
57
Neutral
Natera1.82%$124.14M$26.46B52.14%
70
Neutral
Vertex Pharmaceuticals1.77%$120.87M$106.97B-12.18%
75
Outperform

XBI Technical Analysis

Technical Analysis Sentiment
Positive
Last Price
Price Trends
50DMA
99.84
Positive
100DMA
92.86
Positive
200DMA
88.49
Positive
Market Momentum
MACD
3.35
Negative
RSI
71.03
Negative
STOCH
82.15
Negative
Evaluating momentum and price trends is crucial in ETF analysis to make informed investment decisions. For XBI, the sentiment is Positive. The current price of undefined is equal to the 20-day moving average (MA) of 107.59, equal to the 50-day MA of 99.84, and equal to the 200-day MA of 88.49, indicating a bullish trend. The MACD of 3.35 indicates Negative momentum. The RSI at 71.03 is Negative, neither overbought nor oversold. The STOCH value of 82.15 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for XBI.

XBI Peer Comparison

Comparison Results
Name
Price
Price Target
AUM
Expense Ratio
Overall Rating
$6.81B0.35%
59
Neutral
$6.61B0.44%
66
Neutral
$4.24B0.38%
74
Outperform
$3.03B0.38%
73
Outperform
$2.63B0.08%
72
Outperform
$1.15B0.54%
69
Neutral
Performance Comparison
Ticker
Company Name
Price
Change
% Change
XBI
SPDR S&P BIOTECH ETF
111.91
14.93
15.39%
IBB
iShares Biotechnology ETF
IHI
iShares U.S. Medical Devices ETF
IYH
iShares U.S. Healthcare ETF
FHLC
Fidelity MSCI Health Care Index ETF
FBT
First Trust NYSE Arca Biotechnology Index Fund
Glossary
BuyAn ETF rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF is likely to deliver higher returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldAn ETF rated as a "Hold" s expected to perform in line with the overall market or a specific benchmark. This rating indicates that the ETF is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellAn ETF rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF may deliver lower returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst ETF Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in ETFs carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: ―
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