Clinical TrialsVentyx recently reported topline data from its open-label Phase 2a study with its CNS-penetrant NLRP3 inhibitor, VTX3232, in early Parkinson’s disease, where target engagement, reductions in downstream biomarkers of NLRP3 inhibition, and safety were demonstrated.
Innovation And R&DVentyx is planning to next conduct a placebo-controlled Phase 2 Parkinson's disease study with VTX3232, and is evaluating additional neurodegenerative disorders such as Alzheimer's disease.
Treatment OutcomesVTX3232 combined with semaglutide led to additive reductions in body weight and food intake, showing potential for improved treatment outcomes.