Clinical SetbacksRisks include negative proof-of-concept efficacy data for zelnecirnon in Phase 2b testing in AD, failure to advance zelnecirnon into pivotal testing in allergic conditions, and inability to secure regulatory approval for zelnecirnon.
Financial StrainThe company announced a 40% workforce reduction to conserve cash resources, indicating financial strain.
Regulatory IssuesThe FDA placed a clinical hold on zelnecirnon trials due to a case of liver failure, leading to the closure of Phase 2 trials.